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the VCA West Los Angeles Animal Hospital by means of an automated hemostasis analyzer d and analyzed with the manufacturer's analytical software. e Briefly, each blood sample was activated with kaolin f in accordance with instructions provided by

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in American Journal of Veterinary Research

phosphate), general inflammatory status (canine C-reactive protein), and screening for persistent hyperglycemia (fructosamine) were performed. Platelet concentration, fibrinogen concentration, prothrombin time, activated partial thromboplastin time, and

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in American Journal of Veterinary Research

system of coagulation could have become activated. As blood passed through the filter, the contact system, particularly of coagulation factor XII, could become activated and subsequently consumed during coagulation. 15 Activation of factor XII

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in American Journal of Veterinary Research

conducted in duplicate with kaolin activator, 21 and R-time (time to initial clot formation), α angle (measure of the rate of clot formation), and MA (related to maximum clot strength) were the parameters of interest. Biochemical i analyses were performed

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in American Journal of Veterinary Research

ACOTS is partly attributable to an increase in local release of TPA by damaged endothelial cells. In addition, increased circulating concentrations of activated protein C inhibit plasminogen activator inhibitor-1, an inhibitor of the fibrinolysis pathway

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in American Journal of Veterinary Research

-adrenoceptors on platelet membranes of rats, cattle, and horses. 8 Adrenaline is considered a rather weak platelet agonist, the function of which is primarily to sensitize platelets to other activating agents in humans. 13,1 4 Adrenaline alone does not induce

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in American Journal of Veterinary Research

-canine vWF antibodies. 22 Coagulant activity for FVIII and FIX were measured by use of modified 1-stage activated partial thromboplastin time assays with a semiautomated clot detection instrument, k human FVIII- and FIX-deficient plasmas, l and a rabbit

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in American Journal of Veterinary Research

concentrations. Histamine is primarily synthesized by basophils and mast cells, and, when activated, those cells degranulate and release substantial amounts of histamine into the extracellular matrix. Histamine has an important role in allergic and

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in American Journal of Veterinary Research