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cells and breakdown of the blood-brain barrier. 10,14 Activated microglia are a major source of proinflammatory cytokines, such as TNF-α and IL-6. 15 These cytokines are associated with neuronal damage in several neurologic disorders, including

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in American Journal of Veterinary Research

, Brimer CM , et al. Peroxynitrite-dependent pathway is responsible for blood-brain barrier permeability changes during a central nervous system inflammatory response: TNF-α is neither necessary nor sufficient . J Immunol 2007 ; 178 : 7334 – 7343

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in American Journal of Veterinary Research