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reconstruct cruciate ligaments in horses. 7 Arthroscopic removal of intra-articular boney fragments and damaged tissues has been described, and mesenchymal stem cell therapy has been advocated 6 ; however, generally, an overall poor prognosis regarding

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in Journal of the American Veterinary Medical Association

2 gene mNGS Metatranscriptomic next-generation RNA sequencing MSC Mesenchymal stem cell NCBI National Center for Biotechnology Information nr RNA database nt Genomic database PFFV Puma feline foamy virus RT-PCR Reverse transcription PCR

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in American Journal of Veterinary Research

cellular infiltrates in response to proteinuria . Am J Kidney Dis 2001 ; 37 : S25 – S29 . 10.1053/ajkd.2001.20735 32. Ninichuk V , Gross O , Segerer S , et al. Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay

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in American Journal of Veterinary Research

mandibular aneurysmal bone cyst . Vet Surg . 2022 ; 51 ( 8 ): 1265 - 1272 . doi: 10.1111/vsu.13844 19. Tsuzuki N , Seo JP , Yamada K , et al. The effect of a gelatin β-tricalcium phosphate sponge loaded with mesenchymal stem cells (MSC), bone

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in Journal of the American Veterinary Medical Association

ranging from 23% to 43% in sport horses and 53% to 67% in racehorses. 2–4 With the advent of new biological treatment options such as mesenchymal stem cells, 5,6 growth factor technologies, 7–11 and tissue scaffolding materials, 12–14 there is a need

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in American Journal of Veterinary Research

condyle is often recognized as an early sign of stifle OA. 1 , 3 Thus, a significant amount of research into cartilage healing has been completed for equine OA treatment such as mesenchymal stem cell (MSC) administration and autologous platelet

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in American Journal of Veterinary Research

injection to tendinitis lesions. 19,20 Bone marrow aspirates are of clinical interest as a source of autogenous mesenchymal stem cells and often deliver growth factors to the tendinitis lesion. 21,22 Platelet-enriched plasma concentrates have also emerged

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in American Journal of Veterinary Research

(chondrogenic-induced mesenchymal stem cells). Those horses, however, were not involved in the present study in any way. Because the horses of the present study comprised the placebo group of the larger study, they received a 2-mL injection of saline (0.9% NaCl

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in American Journal of Veterinary Research

, compared with normal-joint chondrocytes in monolayer culture. 37 Mesenchymal stem cells aspirated from bone marrow adjacent to severely arthritic joints in humans have decreased in vitro chondrogenic activity, compared with similar cells from bone marrow

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in American Journal of Veterinary Research

, et al. Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds . Tissue Eng 2007 ; 13 : 1299 – 1312 . 10.1089/ten.2006.0278 7. Gailit J Clarke C

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in American Journal of Veterinary Research