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strain injuries). 1 Mesenchymal stem cells are characterized by their ability to maintain considerable proliferative activity and differentiate along several tissue lineages (ie, multi-potency). These characteristics have generated research interest for

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in American Journal of Veterinary Research
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, Souther A , Schnabel LV . IL-1β + TGF-β2 dual-licensed mesenchymal stem cells have reduced major histocompatibility class I expression and positively modulate tenocyte migration, metabolism, and gene expression . J Am Vet Med Assoc . 2024 ; 262

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in Journal of the American Veterinary Medical Association

be as high as 45% as a result of permanent changes in collagen ECM organization and altered resistance to tensile loading. 9,10 Mesenchymal stem cells have been used in the treatment of tendinitis. 11,12 Most studies 12–14 involving MSCs have

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in American Journal of Veterinary Research

complications. This case is an example of an infarcted cancellous bone and intertrabecular fatty marrow, both of which have undergone necrosis ( Figure 2 ) . Decrease in oxygen tension caused by the loss of vascularity activated mesenchymal stem cell (MSC

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in Journal of the American Veterinary Medical Association

use of mesenchymal stem cells derived from equine bone marrow and adipose tissue Maria L. González-Fernández et al 779 Results indicated that MSCs derived from AT could be a good alternative to MSCs derived from BM for use in regenerative

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in Journal of the American Veterinary Medical Association

evaluation of autologous cultured bone marrow mesenchymal stem cells and bone marrow mononucleated cells in collagenase-induced tendinitis of equine superficial digital flexor tendon . Vet Med Int . 2010 ; 2010 : 250978 . doi: 10.4061/2010/250978 8. Moher

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in Journal of the American Veterinary Medical Association

development (Z-score, −2.133), cell-to-cell signaling and interaction (Z-score, −2.105), organismal injury and abnormalities (Z-score, −1.992), activation of cellular migration (Z-score, 2.312), differentiation of mesenchymal stem cells (Z-score, 2.000), and

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in Journal of the American Veterinary Medical Association

study, Yun et al 85 performed a randomized controlled trial in which PRP, mesenchymal stem cells, or a combination were compared to controls. PRP alone or in combination with mesenchymal stem cells showed a positive effect on lameness and preservation

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in Journal of the American Veterinary Medical Association

Endothelial progenitor cell FBS Fetal bovine serum IFA Indirect immunofluorescence assay MSC Mesenchymal stem cell VEGFR Vascular endothelial growth factor receptor vWF von Willebrand factor Footnotes a. EGM-2 with Bullet Kit, Lonza, Visp

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in American Journal of Veterinary Research

cytokines within an inflammatory microenvironment. 10 Research findings suggest that inflammation is required to induce immunomodulatory effects of mesenchymal stem cells, but inflammation can also have a negative impact on mesenchymal stem cell function

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in American Journal of Veterinary Research