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factors, including transforming growth factor-β and platelet-derived growth factor in platelet-rich plasma, 22 and concentrated bone marrow would be anticipated to have similar increases in growth factors. Further work is needed to confirm this for

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in American Journal of Veterinary Research

histocompatibility complex MSC Mesenchymal stem cell PBMC Peripheral blood mononuclear cell PRP Platelet-rich plasma Footnotes a. Lloyd Laboratories, Shenandoah, Iowa. b. Hospira Inc, Lake Forest, Ill. c. Fort Dodge Animal Health, Fort Dodge, Iowa

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in American Journal of Veterinary Research

oral NSAIDs, corticosteroids, and sodium hyaluronate; and biologics such as platelet-rich plasma, mesenchymal stromal cells, interleukin (IL)-1 receptor antagonist protein, and others. 10 – 17 Most of these treatments decrease pain, but do not

Open access
in American Journal of Veterinary Research

cells and platelet-rich plasma in 3 cats with chronic spinal cord injury refractory to standard treatment and rehabilitation for at least 2 months. The cats were followed for 90 days, and no adverse events were reported. There was no control group. The

Open access
in Journal of the American Veterinary Medical Association

. These include the use of more conservative therapies, such as shockwave therapy, 11 – 14 high-intensity laser therapy, 15 , 16 or injection with biologic agents such as platelet-rich plasma, 17 , 18 as well as surgical procedures, including

Open access
in American Journal of Veterinary Research

clinical improvement is often shortlived. The use of biologic products, such as platelet-rich plasma and autologous stem cells, may be elected; however, there is little evidence to support these treatments for POD. 7 Arthroscopic debridement of diseased

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in Journal of the American Veterinary Medical Association

the use of platelet-rich plasma to improve osseous healing following tibial plateau leveling osteotomy; the skin lesions developed 7 weeks after surgery. Immediately after surgery, the dog received carprofen a (2.3 mg/kg [1.0 mg/lb], PO, q 24 h for 7

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in Journal of the American Veterinary Medical Association

were investigated in vitro using MSCs and platelet-rich plasma from the bottlenose dolphin. 70 Marine mammals frequently suffer wounds from boat strikes and infection is common often leading to the demise of the animal. 71 This therapy could

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in Journal of the American Veterinary Medical Association

portion of the sciatic nerve. Further, a study 34 comparing the efficacy of platelet-rich plasma or bone marrow–derived MSCs in combination with a saphenous vein graft for facial nerve transection in dogs found subjects treated with MSCs showed a

Open access
in Journal of the American Veterinary Medical Association

is used to determine interactions of platelet agonists with either whole blood or platelet-rich plasma. The strong (collagen, arachidonate, and thrombin) or weak (ADP, epinephrine, and ristocetin) platelet agonists may stimulate platelet activation

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in American Journal of Veterinary Research