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cytoplasmic maturation. Evaluation of fine-needle aspirates of the spleen revealed many rubricytes that had morphology that was similar to the rubricytes seen in the aspirates of the liver. Interpretation of these findings suggested that the cat most likely

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in Journal of the American Veterinary Medical Association

Introduction Splenectomy is the treatment of choice for several disorders of the spleen in dogs, including, but not limited to, benign and malignant neoplasia, torsion, hematoma, rupture, infiltrative, and immune-mediated disease. 1 – 5 The

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in Journal of the American Veterinary Medical Association

completely neutralized. A titer > 1:10 was considered positive for anti-CSFV antibody. qRT-PCR assay A qRT-PCR assay was used to detect CSFV C strain copies in spleen lysates obtained from rabbits after they had been euthanized at 4 days after viral

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in American Journal of Veterinary Research

samples of gill, liver, posterior kidney, anterior kidney, spleen, skin and muscle, and scales were collected and placed in sterile 1.5-mL microcentrifuge tubes. Tubes were stored at −80°C for later analysis. For fish euthanized 144 hours after

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in American Journal of Veterinary Research

JPG file format and imported into image analysis software. b Regions of interest were drawn around the peripheral (mandibular, superficial cervical, and popliteal) lymph nodes, liver, and spleen. The intensity of these regions, determined with

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in American Journal of Veterinary Research

enlarged spleen was detected during abdominal palpation. Other physical examination findings were unremarkable. A venous blood sample was collected and submitted for a CBC and serum biochemical analysis. The CBC revealed a slightly low mean corpuscular

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in Journal of the American Veterinary Medical Association

enterica serotype Typhimurium was used and was > 99% pure. g Splenocytes Immediately following euthanasia, an approximately 5-cm 3 portion of fresh spleen was harvested from each of the 8 dogs. The spleen was stored in PBS solution on ice for

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in American Journal of Veterinary Research

evisceration of the spleen, and 1 animal had a perforated colon and was leaking feces into the peritoneal cavity. Information regarding interval from the evisceration event to admission was available for all 12 animals. Specific information was available for

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in Journal of the American Veterinary Medical Association

animals with the linear transducer, but could not be reliably identified with the microconvex transducer. The hemipenes were visualized in 7 of 8 males. The adrenal glands and spleen were not identified in any animal. Weight of males was significantly ( P

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in Journal of the American Veterinary Medical Association

Abstract

Objective—To develop an aerosol exposure method for induction of brucellosis in rhesus macaques ( Macaca mulatta ).

Animals—10 adult rhesus macaques.

Procedure—8 rhesus macaques were challenge exposed with 102 to 105 colony-forming units of Brucella melitensis 16M by use of an aerosol-exposure technique, and 2 served as control animals. All macaques were euthanatized 63 days after challenge exposure. Gross and microscopic lesions, bacterial burden in target organs, and histologic changes in tissues were evaluated.

Results—Grossly, spleen weights were increased in exposed macaques, compared with spleen weights in control macaques. Histologically, there was inflammation in the liver, kidneys, spleen, testes, and epididymides in exposed macaques. The spleen and lymph nodes had increased numbers of lymphohistiocytic cells. Morphometrically, the spleen also had an increased ratio of white pulp to red pulp. Areas of hepatitis and amount of splenic white pulp increased with increasing exposure dose.

Conclusions and Clinical Relevance—Pathologic findings in rhesus macaques after aerosol exposure to B melitensis are similar to those observed in humans with brucellosis.

Impact for Human Medicine—These results may aid in the development of a vaccine against brucellosis that can be used in humans. ( Am J Vet Res 2004;65: 644–652)

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in American Journal of Veterinary Research