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Lynch ME van der Meulen MC , et al. Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons . J Orthop Res 2009 ; 27

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in American Journal of Veterinary Research

(aka mesenchymal stem cells or MSCs) are progenitor cells that can be isolated from bone marrow as well as other tissue sources (eg, placenta, adipose) and have demonstrated some positive results as a regenerative medicine treatment of orthopedic

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in American Journal of Veterinary Research

S ignificant interest has been placed on the potential of mesenchymal stem cells (MSCs) and related animal cell and tissue-based products (ACTPs) to address unmet therapeutic needs in veterinary and human medicine. Despite the promise and the

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in Journal of the American Veterinary Medical Association

CFU-F CFU fibroblast DMEM Dulbecco modified Eagle medium FBS Fetal bovine serum MSC Mesenchymal stem cell SAβ-gal Senescence-associated β-galactosidase a. 13-gauge Jamshidi needle, Allegiance Healthcare Corp, McGaw Park, Ill. b. Novo

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in American Journal of Veterinary Research

enrolled in a clinical trial, received 2 IV injections of 2 X 10 7 ASCs 4 weeks apart, and responded with a cure (B). (Adapted from Quimby JM, Borjesson DL. Mesenchymal stem cell therapy in cats: current knowledge and future potential. J Feline Med Surg

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in American Journal of Veterinary Research

the sample, compared with that of the baseline aspirates. We speculate that by increasing these cell types, an increase in osteoblastic progenitor cells will occur. In 2 previous studies, 36,37 mesenchymal stem cells were isolated from a mononuclear

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in American Journal of Veterinary Research

autologous and allogenic bone marrow–derived mesenchymal stem cell transplantation in canine spinal cord injury . J Neurol Sci 2009 ; 285 : 67 – 77 . 10.1016/j.jns.2009.05.027 2. Lee JB , Kuroda S , Schinohe H , et al. A pre

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in American Journal of Veterinary Research

mesenchymal stem cells in the light of the cancer stem cell hypothesis 9,10 as well as the occurrence of mesenchymal stem cells in canine adipose tisse, 11 it seems reasonable to suggest that the different tissues within mixed mesenchymal tumors arise from a

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in Journal of the American Veterinary Medical Association

Extracellular Vesicles . J Extracell Vesicles . 2014 ; 3 : 26913 . 9. Arzi B , Peralta S , Fiani N , et al . A multicenter experience using adipose-derived mesenchymal stem cell therapy for cats with chronic, non-responsive gingivostomatitis

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in Journal of the American Veterinary Medical Association

which can be used as a source of autogenous multipotent cells for transplantation. Mesenchymal stem cells were identified in bone marrow stroma > 25 years ago 32 ; however, potential drawbacks to the use of bone marrow aspirates to provide a pool of MSCs

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in American Journal of Veterinary Research