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differentiation. Multifocal regions of osteoid were observed forming trabeculae of poorly mineralized bone with osteoclast infiltrates. These results supported the diagnosis of a pleomorphic splenic stromal cell sarcoma. The cell of origin of the mass could not be

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in Journal of the American Veterinary Medical Association

cells. Leydig, thecal, and stromal cells do not express inhibin-α, and thecal and stromal cells express desmin and actin. 7 The strong expression of vimentin and lack of desmin or cytokeratin expression in the neoplastic ovarian tissue removed from the

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in Journal of the American Veterinary Medical Association

fluorescent protein MSC Mesenchymal stem cell References 1. Prockop DJ . Marrow stromal cells as stem cells for nonhematopoietic tissues . Science 1997 ; 276 : 71 – 74 . 10.1126/science.276.5309.71 2. Pittenger MF , Mackay AM , Beck

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in American Journal of Veterinary Research

. Mesenchymal stromal cells for prevention and treatment of graft-versus-host disease: successes and hurdles . Curr Opin Organ Transplant 2015 ; 20 : 72 – 78 . 10.1097/MOT.0000000000000158 3. Vangsness CT Jr , Farr J II , Boyd J , et al

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in American Journal of Veterinary Research

. Guest DJ , Smith MRW , Allen WR . Equine embryonic stem-like cells and mesenchymal stromal cells have different survival rates and migration patterns following their injection into damaged superficial digital flexor tendon . Equine Vet J

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in Journal of the American Veterinary Medical Association

migration translates to the in vivo environment, it may confer benefits to the healing tendon, especially in the early stages of injury following the loss of endogenous stromal cell populations. 30 Following injury, tendon tissue undergoes stages of

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in Journal of the American Veterinary Medical Association

The Confusing Landscape of Mesenchymal Stromal Cell Therapies Mesenchymal stromal cells (MSCs) have been demonstrated in numerous studies to aid in bone repair, 1 skeletal muscle regeneration, 2 – 4 and cartilage regeneration. 5 While MSCs

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in Journal of the American Veterinary Medical Association

, et al. Intra-articular injection of mesenchymal stromal cells in partially torn anterior cruciate ligaments in a rat model . Arthroscopy 2007 ; 23 : 610 – 617 . 10.1016/j.arthro.2007.01.013 2 Centeno CJ Busse A Kisiday J , et al

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in American Journal of Veterinary Research

dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis . Stem Cells 2006 ; 24 : 2493 – 2503 . 10.1634/stemcells.2006-0161 15. Vishnubalaji R , Al-Nbaheen M , Kadalmani B , et al. Skin-derived multipotent stromal cells—an archrival for

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in American Journal of Veterinary Research

K , Keane-Myers A , Brown JM , Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma . Proc Natl Acad Sci USA . 2010 ; 107 ( 12 ): 5652 – 5657 . doi: 10.1073/pnas.0910720107 . 32

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in Journal of the American Veterinary Medical Association