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Summary

Medical records of 36 dogs with synovial sarcoma confirmed by microscopic examination of h&e-stained sections of tissue were selected for retrospective analysis from dogs admitted between 1986 and 1991 to participating institutions of the Veterinary Cooperative Oncology Group. Metastasis was evident at the time of diagnosis in 8 (22%) dogs, and 15 (41%) dogs ultimately developed metastatic tumors. Median survival time for all dogs, as determined by lije-table analysis, was 17 months. For dogs that were subsequently treated and became tumor free, the median disease-free interval was 30 months. Nine dogs had previously had localized excision attempted, but all had recurrence of the tumor locally (median, 4.5 months). Of 29 dogs that underwent amputation, including the 9 with localized recurrence, 2 had tumor recurrence on the amputation stump. Most dogs had survival time and disease-free interval of > 36 months after amputation. Four dogs that had received chemotherapy for tumors of advanced clinical stages did not respond to treatment. One dog that had received locally applied radiotherapy after localized excision did not have evidence of tumor recurrence 2 years after radiotherapy. Clinical stage, histologic grade, and a positive result for tests that used cytokeratin immunohistochemical staining significantly (P < 0.05) influenced survival time and disease-free interval. Analysis of data for the study reported here suggested that histologic criteria can be an excellent predictor of dogs that are likely to have tumor recurrence after amputation and that would most likely benefit from aggressive treatment with adjuvants.

Free access
in Journal of the American Veterinary Medical Association

of the history obtained from the owner, physical examination findings, and clinicopathologic data and graded according to the Veterinary Cooperative Oncology Group. 35 This system was applied retrospectively to categorize documented adverse effects

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in Journal of the American Veterinary Medical Association

from 6 PetCure Oncology locations with a histologic diagnosis of a narrowly (< 3 mm) 7 or incompletely excised grade II or III STS were prospectively enrolled into this study. Each dog was treated with a standardized protocol incorporating a single

Open access
in Journal of the American Veterinary Medical Association

. However, on the basis of our results, it was impossible to make direct comparisons with control dogs treated with local therapy alone. ABBREVIATIONS CI Confidence interval DFI Disease-free interval NEVOG New England Veterinary Oncology

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in Journal of the American Veterinary Medical Association

with low-grade STSs and would increase with tumor grade. Materials and Methods Animals Medical records from the Fitzpatrick Referrals Oncology and Soft Tissue Hospital were searched for records of dogs with histologically confirmed STSs

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in Journal of the American Veterinary Medical Association

1998 ; 34 : 451 – 456 . 10.5326/15473317-34-6-451 3. Selting KA . Intestinal tumors . In: Withrow SJ Vail D , eds. Small animal clinical oncology . 5th ed. St Louis : Saunders Elsevier , 2013 ; 412 – 423 . 4. Paoloni MC Penninck

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in Journal of the American Veterinary Medical Association

March 2020 with the Surgical Oncology Service at VCA West Coast Specialty and Emergency Animal Hospital were reviewed. Dogs were included if they were ≥ 8 years of age at presentation, underwent a major surgical procedure under general anesthesia, and

Open access
in Journal of the American Veterinary Medical Association

Abstract

OBJECTIVE

Deep-seated pulmonary lesions can be difficult to sample safely. The objective of this study was to determine the relative safety and accuracy of fluoroscopy-guided fine-needle aspiration of deep-seated pulmonary lesions regardless of their size and depth.

ANIMALS

Client-owned animals; 5 dogs and 5 cats.

CLINICAL PRESENTATION

Pulmonary lesion locations were determined on dorsoventral and lateral views using fluoroscopy. The lateral thoracic wall was aseptically scrubbed, and an indelible marker was used to mark the point of entry of the needle for sampling. The path of a 22-gauge needle attached to a syringe was followed using fluoroscopic guidance. Mass volume (Vma) and distance from skin and pleura to lesion (DSK-L and DPL-L) were recorded.

RESULTS

In dogs, mean Vma was 137.2 cm3 (range, 6.3 to 426.2 cm3). Mean DSK-L was 71 mm (range, 37 to 101 mm) and DPL-L was 33 mm (range, 16 to 71 mm). Exfoliative cytology results were consistent with carcinoma in 4 dogs and lymphoma in 1 dog. A minor postprocedural complication was noted in 1 dog. In cats, the mean Vma was 2.4 cm3 (range, 1.6 to 3.7 cm3). Mean DSK-L was 42 mm (range, 20 to 75 mm) and DPL-L was 21 mm (range, 12 to 32 mm). Cytology results were consistent with pulmonary carcinoma in 2 cats, inflammation in 2 cats, and necrotic debris in 1 cat.

CLINICAL RELEVANCE

Fluoroscopy-guided fine-needle aspiration of pulmonary masses is a safe and accurate technique to obtain cytologic samples irrespective of the size and depth of the lesions.

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in Journal of the American Veterinary Medical Association

. c. GraphPad Prism, version 6.07, Graphpad Software Inc, San Diego, Calif. References 1. Liptak JM , Forrest LJ . Soft-tissue sarcomas . In: Withrow SJ , Vail DM , eds. Withrow and MacEwen's small animal clinical oncology . 4th

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in Journal of the American Veterinary Medical Association

Medicine and the Harrington Oncology Program at Tufts University School of Veterinary Medicine. The study protocol was approved by an institutional animal care and use committee at each institution, and written informed consent was obtained from all clients

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in American Journal of Veterinary Research