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closely regulated along with phosphorus via parathyroid hormone (PTH), calcitriol (1,25-dihydroxyvitamin D3), and calcitonin. 1 – 3 During periods of hypocalcemia, PTH secretion increases plasma calcium via mobilization of calcium and phosphorus from bone

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in Journal of the American Veterinary Medical Association

hyperparathyroidism may be a result of development of parathyroid adenoma, parathyroid carcinoma, or parathyroid hyperplasia. Regardless of etiopathogenesis, PHPT results in excess PTH secretion by chief cells in the parathyroid gland, which causes an increase in

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in Journal of the American Veterinary Medical Association

key factors, including intestinal absorption, renal excretion, and phosphorus uptake into cells. Calcitriol increases phosphorus absorption from the gastrointestinal tract and from skeletal tissue, and PTH causes bone resorption and activates

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in Journal of the American Veterinary Medical Association

phosphatase activity (230 U/L; age-adjusted reference range, 2 37 to 333 U/L). Urine specific gravity was concentrated at > 1.050. A serum parathyroid hormone (PTH), calcium, and vitamin D profile revealed a mildly high concentration of PTH (33 pg/mL; age

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in Journal of the American Veterinary Medical Association

fifth day of hospitalization, an additional serum sample that was obtained after food had been withheld from the dog was submitted for analyses of PTH, 25(OH)D 3 , and ionized calcium concentrations; sample handling was performed as directed by the

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in Journal of the American Veterinary Medical Association

, compared with PTH concentration in cats that remained nonazotemic. Importantly, PTH concentration increased before changes in plasma calcium and phosphate concentrations were detected. See page 1326 Hemostatic and fibrinolytic markers in dogs

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in Journal of the American Veterinary Medical Association

. Concentrations of ionized calcium and PTH in serum and phosphorus and creatinine in plasma were also determined in these samples. Dietary supplementation trial Animals— Seven 4-year-old sexually intact male (n = 4) and female (3) Beagles were used in this

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in American Journal of Veterinary Research

Plasma PTH concentration was determined by use of a radioimmunoassay. g Plasma 1,25-dihydroxyvitamin D 3 concentration was determined by use of a commercially available ELISA. h Ileal lymphocyte subpopulations For each ileum specimen, the mucosa

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in American Journal of Veterinary Research

, magnesium, PTH, and calcitriol concentrations. Horses were maintained in paddocks and were fed the same diet (hay, oats, and a vitamin-mineral supplement) for at least 2 months before blood sample collection. Experimental protocols were reviewed and approved

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in American Journal of Veterinary Research

venous blood gas analysis, i urinalysis, quantitative aerobic bacteriologic culture of urine, indirect blood pressure measurements, serum ionized calcium analysis, j and serum PTH concentration analysis j ( Table 2 ). Although all of these analytes

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in Journal of the American Veterinary Medical Association