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strategies to reduce antimicrobial usage, including regenerative therapies such as mesenchymal stromal cell (MSC)-based treatments and platelet lysate. 4 – 8 MSCs have inherent antimicrobial and immunomodulatory properties through antimicrobial peptide and

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in Journal of the American Veterinary Medical Association

tissues lost to trauma or disease is rapidly becoming a reality with standardization of cell sources, biocompatible scaffold templates, and culture conditions that simulate in vivo environments. 7 Adult multipotent stromal cells (MSCs) derived from

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in American Journal of Veterinary Research

. Lacy Kamm, Assistant Professor of Large Animal Surgery, is investigating the use of autologous and allogeneic mesenchymal stromal cells in the treatment of degenerative, inflammatory conditions including osteoarthritis, tendonitis, and desmitis in

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in American Journal of Veterinary Research

negating the need for immunosuppression. 6,7 However, for clinical use, it is critical to be able to harvest tissues to be used as stem cell sources without causing adverse effects to the patient. 8,9 Adipose tissue-derived stromal cells are a promising

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in American Journal of Veterinary Research

tissue, and a limited reparative magnitude of articular cartilage in joints. Regenerative medicine aims to heal and restore normal aspects of the tissue affected by using scaffolds, growth factors, or cell-based therapies. 5 Mesenchymal stromal cells

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in American Journal of Veterinary Research

, growth factor-binding proteins and growth factor precursors, receptor tyrosine kinases, cell adhesion molecules, and other proteases. 17 Thus, MMPs are instrumental in the molecular crosstalk between tumor and stromal cells. 18 The exact location of

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in American Journal of Veterinary Research

has been suggested that both tumor and stromal cell components may cooperate, which enables tumor cells to reach their target organ and survive the metastatic process. 3,7–9 Thus, MMP-2 and -9 in tumor stromal elements has been reported in several

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in American Journal of Veterinary Research

-immunogenicity balance, cell viability, and differentiation potential . Stem Cells Dev . 2017 ; 26 ( 1 ): 15 – 24 . doi: 10.1089/scd.2016.0209 13. Le Blon D , Hoornaert C , Detrez JR , et al . Immune remodelling of stromal cell grafts in the central nervous

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in Journal of the American Veterinary Medical Association

into a syringe. The following measures were recorded from concentrate samples: total volume, PCV, total nucleated cell count, RBC count, and differential cell count. Concentrate samples were also used for bone marrow–derived stromal cell culture. Bone

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in American Journal of Veterinary Research

International Society of Stem Cell Research (ISSCR) recommends the use of the terminology “mesenchymal stromal cell” to denote their tissue of origin. 4 However, many authors continue to use the term “mesenchymal stem cell” due to the widespread familiarity

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in Journal of the American Veterinary Medical Association