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of autologous cells such as bone marrow stromal cells, which have been characterized as MSCs. 11 Recently, the use of autologous bone marrow–derived MSCs to treat superficial flexor tendon injuries has been reported. 12 Mesenchymal stem cells have

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in American Journal of Veterinary Research

tissue injuries and ischemic diseases. ABBREVIATIONS ASC Adipose tissue–derived mesenchymal stem cell EGM-2 Endothelial growth medium-2 FACS Fluorescence-activated cell sorting EPC Endothelial progenitor cell FBS Fetal bovine serum

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in American Journal of Veterinary Research

articular cartilage. 7 Mesenchymal stem cells are pluripotential cells capable of differentiating into multiple types of connective tissue cells. 8 Mesenchymal stem cells have been recognized as an attractive resource for the repair of musculoskeletal

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in American Journal of Veterinary Research

Extracellular matrix GAG Glycosaminoglycan HA Hyaluronic acid MSC Mesenchymal stem cell MW Molecular weight SEM Scanning electron microscopy TGF Transforming growth factor a. D1 ORL UVA, American Type Culture Collection, Manassas, Va. b

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in American Journal of Veterinary Research

protein-2 AdGFP Adenoviral vector containing green fluorescent protein BMP Bone morphogenic protein ECM Extracellular matrix FBS Fetal bovine serum GFP Green fluorescent protein HA Hyaluronic acid MSC Mesenchymal stem cell PG Proteoglycan

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in American Journal of Veterinary Research

International Society for Cellular Therapy position statement. Cytotherapy 2006 ; 8 : 315 – 317 . 2 Chamberlain G Fox J Ashton B et al . Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features

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in American Journal of Veterinary Research

Despite the advances in veterinary surgery and medicine, treatment of many canine orthopedic and neurologic conditions often does not result in the desired clinical outcome or patient's return to normal function. Mesenchymal stem cells have shown

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in American Journal of Veterinary Research

Mesenchymal stem cells are fibroblast-like, highly proliferative, plastic-adherent cells with the ability to differentiate into various tissues including bone, cartilage, tendon, and muscle. 1 Refinement of MSC isolation and expansion techniques

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in American Journal of Veterinary Research

has sustained interest in the use of autologous MSCs in equine clinics and fostered the formation of commercial processing services to meet this demand. 7 Mesenchymal stem cells represent a small percentage of the nucleated cell population in bone

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in American Journal of Veterinary Research

Jose María Maniega for assistance with histologic examinations. ABBREVIATIONS AT Adipose tissue AT-MSC Adipose tissue-derived mesenchymal stem cell BM Bone marrow BM-MSC Bone marrow-derived mesenchymal stem cell MSC Mesenchymal stem

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in American Journal of Veterinary Research