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. 10.1007/s10577-014-9406-z 27. Murai A Abou Asa S Kodama A , et al. Immunohistochemical analysis of the Akt/mTOR/4E–BP1 signalling pathway in canine haemangiomas and haemangiosarcomas . J Comp Pathol 2012 ; 147 : 430 – 440 . 10.1016/j

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in Journal of the American Veterinary Medical Association

growth hormone (GH) and insulin-like growth factor-1 (IGF-1); insulin and other factors regulating glucose metabolism; mechanistic target of rapamycin (mTOR; a serine/threonine protein kinase, involved in regulation of protein metabolism); and systems

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in American Journal of Veterinary Research

classical (CD14 ++ CD16 - ) monocytes via PI3K/Akt/mTOR-dependent signalling pathway . Immunobiology 2017 ; 222 : 1 – 10 . 10.1016/j.imbio.2015.06.019 16. Haywood-Watson RJ , Holcomb JB , Gonzalez EA , Modulation of syndecan-1

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abnormalities via inhibition of mTOR in osteoarthritis . Biomaterials . 2019 ; 206 : 87 – 100 . doi: 10.1016/j.biomaterials.2019.03.022 10.1016/j.biomaterials.2019.03.022 39. Wong KL , Zhang S , Wang M , Intra-articular injections of mesenchymal

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in Journal of the American Veterinary Medical Association

; 7 ( 3 ): 195 – 205 . 8. Colapietro A , Yang P , Rossetti A , The botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits growth of human glioblastoma, reduces Akt/mTOR activities, and modulates GSC cell

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in Journal of the American Veterinary Medical Association

X , Zhang Q . MiR-21 modulates proliferation and apoptosis of human airway smooth muscle cells by regulating autophagy via PARP-1/AMPK/mTOR signalling pathway . Respir Physiol Neurobiol . 2022 ; 301 : 103891 . doi: 10.1016/j.resp.2022

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in American Journal of Veterinary Research

. Nutr Metab (Lond) 2011 ; 8 : 1 – 4 . 113. Sengupta S Peterson TR Sabatini DM . Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress . Mol Cell 2010 ; 40 : 310 – 322 . 10.1016/j.molcel.2010.09.026 114

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aggressive subset of human peripheral T-cell lymphoma not otherwise specified.” Category of experimental disease, First place: Drs. Travis K. Meuten and Douglas H. Thamm, Colorado State University, for “Evaluation of efficacy of dual P13K/AKT/MTOR pathway

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in Journal of the American Veterinary Medical Association