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information regarding diseases associated with diffuse airway inflammation, resulting in information that differs from the information obtained by cytologic evaluation of BAL fluid. Bronchoalveolar lavage fluid represents processes involving the airway lumens

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in American Journal of Veterinary Research

BAL Bronchoalveolar lavage BALF Bronchoalveolar lavage fluid IQR Interquartile range MA Manual aspiration MAPT Manual aspiration via polyethylene tubing SPA Suction pump aspiration a. Arnolds dog catheter with female Luer mount, 8F

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in American Journal of Veterinary Research

2012 were reviewed to identify client-owned dogs with LRT disease that had a bronchoalveolar lavage performed (n = 131). For dogs to be included, BALF had to have been obtained and submitted to the University of Illinois Clinical Pathology Laboratory

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in Journal of the American Veterinary Medical Association

, September 2018. The authors thank Joey Morgan, who provided valuable expertise and assistance with laboratory analysis. Abbreviations BALF Bronchoalveolar lavage fluid SP-D Surfactant protein D Footnotes a. Dormosedan, Zoetis

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in American Journal of Veterinary Research

test results; hence, this examination technique is an alternative to performing the full range of screening tests for lungworm on BAL fluid when a fecal sample is available. Bronchoalveolar lavage, rather than endotracheal wash, was selected for this

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in Journal of the American Veterinary Medical Association

obtained from each calf during a particular sample acquisition were considered pooled. BAL method Bronchoalveolar lavage fluid samples were obtained by use of a technique adapted from a previous description. 8 Briefly, an unsedated calf was

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in American Journal of Veterinary Research

PIIINP as a marker of fibrosis in these young animals. ABBREVIATIONS PIIINP Procollagen type III amino terminal propeptide BALF Bronchoalveolar lavage fluid CMP Cardiomyopathy DVD Degenerative valve disease CRF

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in American Journal of Veterinary Research

Abstract

Objective—To determine whether treatment of horses with antitussive agents before bronchoalveolar lavage (BAL) reduces the frequency and intensity of the cough reflex during BAL.

Animals—8 healthy horses.

Procedure—Standard BAL was performed on each horse weekly for 6 weeks. Detomidine was used as a general sedative, and various antitussive agents were evaluated for their suitability to suppress undesirable coughing. Treatments administered prior to BAL consisted of saline (0.9% NaCl) solution (control treatment), codeine, butorphanol tartrate, glycopyrrolate, lidocaine hydrochloride (final concentration, 0.33%), and lidocaine hydrochloride at a final concentration of 0.66% (lidocaine 0.66%). Frequency and intensity of coughing were digitally recorded throughout the BAL procedure. The volume of BAL fluid collected was measured, and the fluid was cytologically examined to assess potential effects of the medications on composition.

Results—Coughing frequency was significantly reduced after intratracheal administration of lidocaine 0.66%. Moreover, intratracheal administration of lidocaine 0.66% or IV administration of butorphanol resulted in a significant reduction in the intensity of coughing episodes. All other treatments failed to significantly suppress coughing frequency and intensity, compared with results for the saline treatment. Glycopyrrolate caused obvious adverse clinical effects. Treatments did not influence the volume of BAL fluid collected nor composition of the fluid.

Conclusions and Clinical Relevance—Intratracheal administration of lidocaine (final concentration, 0.66%) proved to be the most reliable method to reduce frequency and intensity of coughing in horses during BAL. (Am J Vet Res 2005;66:1420–1424)

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in American Journal of Veterinary Research

Mike Scott for technical assistance. ABBREVIATIONS ATA Atmosphere absolute BAL Bronchoalveolar lavage GAPDH Glyceraldehyde-3-phosphate dehydrogenase HBO Hyperbaric oxygen HPRT Hypoxanthine ribosyltransferase IL Interleukin RPL-32

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in American Journal of Veterinary Research

Bronchoalveolar lavage is described as a liquid biopsy 1 and is a commonly used technique for collection of samples of respiratory secretions from the lower airways and alveoli in veterinary and human medicine. 2–4 The analysis of BALF samples

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in American Journal of Veterinary Research