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diagnosis: aortic atherosclerosis with aneurysm and rupture. Case summary: ruptured aortic aneurysm caused by atherosclerosis in a flamingo. Comments Atherosclerosis is a common disease process found in avian species. Factors that contribute to its

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in Journal of the American Veterinary Medical Association

Abstract

Objectives

To address the problem of heparin binding to leukocytes of various animal species.

Design

Leukocytes of the various species were incubated with fluorescent-labeled, low molecular mass heparin (LMMH). Fluorescence intensity on granulocytes, lymphocytes, and monocytes was analyzed by flow cytometry analysis.

Sample Population

Leukocytes were prepared from EDTA-anticoagulated blood of human subjects, rats, rabbits, dogs, pigs, and sheep 3 times.

Procedure

The leukocyte populations were identified by their light scatter properties. In addition, phycoerythrin-labeled CD4, CD13, and CD14 antibodies were used to identify human lymphocytes, granulocytes, and monocytes; CD4, GR-1, and CD11b antibodies were used for mouse, and CD45, RP 3, and ED 9 antibodies were used for identification of rat leukocyte subpopulations.

Results

Granulocytes, monocytes, and lymphocytes of all species bound LMMH in dose-dependent manner. Binding of LMMH-tyramine (tyr)-fluorescein-5-isothiocyanate (FITC) to granulocytes was higher in human subjects, rats, rabbits, dogs, and pigs, compared with binding to monocytes and lymphocytes. Mouse and sheep granulocytes did not bind more heparin than monocytes or lymphocytes. Binding of LMMH-tyr-FITC was reversible in the presence of unlabeled heparin or LMMH. More than 99% of human, rat, rabbit, dog, and sheep granulocyte populations were distinguished from monocytes and lymphocytes by means of their fluorescence intensity owing to LMMH-tyr-FITC. This separation was not obtained for mouse and pig granulocytes.

Conclusion

Evidence of specific heparin binding to granulocytes of many species indicates the relevance of fluorescent-labeled LMMH for biological investigations.

Clinical Relevance

Binding of heparin and LMMH to granulocytes, lymphocytes, and monocytes may have a substantial role in atherosclerosis, inflammation, malignancy, and immunologic diseases. (Am J Vet Res 1996;57:1016–1020)

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in American Journal of Veterinary Research

atherosclerosis in pet psittacine birds Results of a new study suggest that infection with Chlamydophila psittaci and high plasma cholesterol concentration may be risk factors for atherosclerosis in pet psittacine birds. In the study, necropsy reports were

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in Journal of the American Veterinary Medical Association

Atherosclerosis is a common disease of aging parrots as suggested by results of retrospective pathologic surveys. 1–6 The disease is characterized by the thickening of arterial walls through lipid accumulation and plaque formation in the tunica

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in American Journal of Veterinary Research

signalment and history was provided. See page 1688 Prevalence of and risk factors associated with atherosclerosis in psittacine birds Information is lacking on the prevalence of and risk factors for atherosclerosis in psittacine birds. In a

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in Journal of the American Veterinary Medical Association

NUTRITION Modification of dietary omega-3 fatty acids for birds with atherosclerosis Many avian species naturally develop or are easily induced to develop atherosclerosis. Various studies have explored the effect of providing supplemental unsaturated

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in Journal of the American Veterinary Medical Association

, and administration of dantrolene, clindamycin, furosemide, mannitol, and enrofloxacin. The dog made a rapid and complete recovery. See PAGE 1049 Chronic cor pulmonale secondary to pulmonary atherosclerosis in an African Grey parrot A

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in Journal of the American Veterinary Medical Association

-grade histologic lesions were found in 99% of psittacine birds. Atherosclerosis in 11 to 17 orders of birds (depending on references and taxonomic classifications used) has been reported, 3 with the Coraciiformes, Bucerotiformes, Struthioniformes, Falconiformes

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in Journal of the American Veterinary Medical Association

this dog so the presence or absence of systemic atherosclerotic plaques could not be determined. Atherosclerosis in dogs has been associated with hypothyroidism and diabetes mellitus. 9,10 Shetland Sheepdogs are predisposed to hypothyroidism, 11 but

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in Journal of the American Veterinary Medical Association

the basis of computed tomographic findings and was later confirmed on histologic examination. 13 In humans, acute ischemic strokes are caused by emboli, and the etiology includes systemic hypertension, cardioembolism, and atherosclerosis. 14 Causes

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in Journal of the American Veterinary Medical Association