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. Antimicrobial susceptibility testing —Isolates were assessed for susceptibility to 16 antimicrobials. Minimum inhibitory concentrations of isolates were determined by use of a semiautomated antimicrobial susceptibility system d and interpreted according to the

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in Journal of the American Veterinary Medical Association

% of the isolates was 1.0 μg/mL for all 4 groups of isolates. For all 4 quality control strains, minimum inhibitory concentrations were within expected ranges ( S aureus ATCC 29213, 0.12 to 0.25 μg/mL; E faecalis ATCC 29212, 0.5 to 1.0 μg/mL; E coli

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in American Journal of Veterinary Research

Escherichia coli, Salmonella spp., and Pasteurella multocida isolates . Avian Dis 2009 ; 53 : 89 – 93 . 10.1637/8268-021608-Reg.1 16. Salmon SA Watts JL . Minimum inhibitory concentration determinations for various antimicrobial agents against

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in American Journal of Veterinary Research

Minimum inhibitory concentration MIC 90 Minimum inhibitory concentration required to inhibit the growth of 90% of bacteria MTT Mean transit time T 1/2λz Terminal elimination half-life Tmax Time of observed maximum drug concentration UPLC

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in American Journal of Veterinary Research

and welfare. CP Chloramphenicol TP Thiamphenicol FFC Florfenicol CAT CP acetyltransferase CmlA CP efflux pump Flo FFC efflux pump MIC Minimum inhibitory concentration AMP Ampicillin DSM

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in American Journal of Veterinary Research

and β-lactamase–producing staphylococci are resistant to penicillin G. Because penicillin is a time-dependent antimicrobial (time > minimum inhibitory concentration [MIC]), the plasma free-drug concentration (ie, unbound drug) must be maintained

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in Journal of the American Veterinary Medical Association

lipid soluble and, in cattle, maintains concentrations in lung tissue greater than the minimum inhibitory concentration (2.0 μg/mL) for the primary respiratory pathogens for at least 7 days. 10 The longlasting properties and high degree of lipid

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in Journal of the American Veterinary Medical Association

instances, multiple organisms were isolated from the same sample; therefore, total number of isolates may not match total number of samples with bacterial growth. Table 3— Minimum inhibitory concentration of selected antimicrobials against

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in Journal of the American Veterinary Medical Association

based on the minimum inhibitory concentration of the bacteria. Antimicrobials were considered effective if the mean urine concentration of the antimicrobial was 4 times the minimum inhibitory concentration for a bacterial species. Bacterial isolates

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in Journal of the American Veterinary Medical Association

-MS-MS Liquid chromatography–mass spectrometry–mass spectrometry MIC Minimum inhibitory concentration PELF Pulmonary epithelial lining fluid Tmax Time to achieve maximum plasma concentration Footnotes a. Foreman JH, Hungerford LL, Folz SD

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in American Journal of Veterinary Research