Search Results

You are looking at 101 - 110 of 2,086 items for :

  • "activation" x
  • Refine by Access: All Content x
Clear All

activation of coagulation and has been reported in up to 62% of humans with solid malignant tumors and 12% of dogs with solid malignant tumors, including dogs with mammary gland cancer. 7,8 Despite being recognized as a clinical complication for decades, the

Full access
in American Journal of Veterinary Research

p38 , and MAPK JNK . 9 In previous in vitro studies, 10,11 MAPK p38 and MAPK JNK were activated at early time points after infection of bovine monocytes with MAP organisms. The MAPK p38 induced expression of the anti-inflammatory cytokine IL-10

Full access
in American Journal of Veterinary Research

Mycobacterium avium subsp paratuberculosis is the etiologic agent of Johne's disease, a severe chronic enteritis of ruminants. 1 Survival of this organism in the body appears to be attributable to its capacity to block activation of

Full access
in American Journal of Veterinary Research

This approach is also widely advocated for disorders of myocardial failure (eg, dilated cardiomyopathy). 2–8 Administration of the loop diuretic furosemide can result in activation of the RAAS in dogs, which calls into question its use as a lone

Full access
in American Journal of Veterinary Research

provide at least some of the hemostatic properties. 16 In vitro studies have revealed that various saponins are capable of inducing a strong activation response in human platelets. 17,18 Moreover, preliminary clinical trials of humans have indicated some

Full access
in American Journal of Veterinary Research

–3 Platelet activation leads to expression of adhesion molecules on their surface, mediating platelet aggregation and interaction with other cells such as endothelial cells and leukocytes. 4–6 Once activated, platelets release and express P-selectin (CD62P

Full access
in American Journal of Veterinary Research

Preanalytic errors attributable to collection of blood samples should be avoided, especially when evaluation of the activation of the coagulation process is of interest. The optimum technique for collection of blood samples for use in coagulation

Full access
in American Journal of Veterinary Research

Activated protein C is an endogenous anticoagulant found in plasma. It is derived from protein C zymogen, which is synthesized by hepatocytes and circulates in plasma at low concentrations. Upon activation by thrombin, APC inhibits the activities

Full access
in American Journal of Veterinary Research

the VCA West Los Angeles Animal Hospital by means of an automated hemostasis analyzer d and analyzed with the manufacturer's analytical software. e Briefly, each blood sample was activated with kaolin f in accordance with instructions provided by

Full access
in American Journal of Veterinary Research

outer membrane leaflet is a sensitive indicator of platelet activation that can be detected by use of FITClabeled annexin V, which specifically binds to phosphatidylserine. Five frozen PCs were used for the flow cytometry analysis. Fresh platelet

Full access
in American Journal of Veterinary Research