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  • Author or Editor: Thomas L. Seahorn x
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SUMMARY

Objective

To determine whether horses with summer pasture-associated obstructive pulmonary disease (SPAOPD) have increased concentrations of antigen-specific IgG and IgE in tracheal lavage fluid, compared with values in clinically normal horses.

Animals

8 horses (6 females, 2 geldings; 6 Quarter Horses, 2 Appaloosas), 14 to 23 years old and with previous diagnosis of SPAOPD, served as the principal group; 8 horses (2 females, 6 geldings; 1 Quarter Horse, 7 Thoroughbreds), 6 to 9 years old, with no evidence of respiratory tract disease, served as the control group.

Procedure

Data were collected twice during a 1- year period: when all SPAOPD-affected horses were manifesting clinical signs of disease (July), and when all SPAOPD-affected horses appeared clinically normal (February). On each occasion, clinical evaluations were performed and blood and tracheal lavage fluid samples were collected. Transtracheal lavage supernatant was evaluated for mold antigen-specific IgG and IgE concentrations.

Results

Median IgE relative antibody unit (RAU) values were significantly higher in control, compared with principal, horses. The SPAOPD-affected horses had increased concentrations of specific IgG for only 1 antigen, during winter sample collection.

Conclusion

Antigen-specific IgG and IgE RAU values were not increased in SPAOPD-affected horses when these horses were manifesting clinical signs of disease. (Am J Vet Res 1997;58:1408–1411)

Free access
in American Journal of Veterinary Research

SUMMARY

The immunotherapeutic effect of low-dose human alpha interferon on viral shedding and clinical disease was evaluated in horses inoculated with equine herpesvirus- 1 (ehv-1). Eighteen clinically healthy weanling horses, 5 to 7 months old, were allotted to 3 equal groups. Two groups were treated orally with human α-2a interferon (0.22 or 2.2 U/kg of body weight), on days 2 and 1 before inoculation with ehv-1, the day of inoculation, and again on postinoculation day 1. The horses of the remaining group were given a placebo orally on the same days. The horses were monitored daily for changes in body temperature and for clinical signs of respiratory tract disease. Blood and nasal swab specimens were collected daily for virus isolation. Blood was also collected at intervals throughout the monitoring period for evaluation of cbc, serum IgG and IgM concentrations, and antibody titers to ehv-1. Febrile responses, nasal discharge, viral shedding, changes in cbc, and an increase in antibody titers to ehv-1 were noticed in all horses after inoculation. There was no significant difference (P > 0.05) in mean values of the factors measured between treatment and control groups.

Free access
in American Journal of Veterinary Research