Objective—To identify clinical features of Corynebacterium
urealyticum urinary tract infection in dogs and
cats and antimicrobial susceptibility patterns of C urealyticum
Animals—5 dogs and 2 cats.
Procedure—Medical records of dogs and cats for
which C urealyticum was isolated from urine samples
were reviewed. Isolates from clinical cases, along
with previously lyophilized unsubtyped isolates of
Corynebacterium spp collected between 1977 and
1995, were examined and, if subtyped as C urealyticum,
tested for antimicrobial susceptibility.
Results—Signalment of infected animals was variable.
Prior micturition disorders were common, and all
animals had signs of lower urinary tract disease at the
time C urealyticum infection was diagnosed. Median
urine pH was 8.0; WBCs and bacteria were variably
seen in urine sediment. In vitro antimicrobial susceptibility
testing of 14 C urealyticum isolates revealed that
all were susceptible or had intermediate susceptibility
to chloramphenicol, tetracycline, and vancomycin and
most were susceptible to enrofloxacin. Thickening of
the bladder wall and accumulation of sediment were
common ultrasonographic findings. Contrast radiography
or cystoscopy revealed findings consistent with
encrusting cystitis in 3 dogs. Infection resolved in 2
dogs following surgical debridement of bladder
plaques and antimicrobial administration. In 2 other
dogs and 1 cat treated with antimicrobials, infection
with C urealyticum resolved, but urinary tract infection
with a different bacterial species developed.
Conclusions and Clinical Relevance—Results suggest
that preexisting urinary tract disorders are common in
dogs and cats with C urealyticum infection. Treatment
with appropriate antimicrobials in combination with surgical
debridement might eliminate C urealyticum infection.
(J Am Vet Med Assoc 2005;226:1676–1680)
Objective—To compare incidence of diabetes mellitus in cats that had undergone renal transplantation with incidence in cats with chronic renal failure, compare mortality rates in cats that underwent renal transplantation and did or did not develop diabetes mellitus, and identify potential risk factors for development of posttransplantation diabetes mellitus (PTDM) in cats.
Design—Retrospective case series.
Animals—187 cats that underwent renal transplantation.
Procedures—Medical records were reviewed.
Results—26 of the 187 (13.9%) cats developed PTDM, with the incidence of PTDM being 66 cases/1,000 cat years at risk. By contrast, the incidence of diabetes mellitus among a comparison population of 178 cats with chronic renal failure that did not undergo renal transplantation was 17.9 cases/1,000 cat years at risk, and cats that underwent renal trans-plantation were 5.45 times as likely to develop diabetes mellitus as were control cats with chronic renal failure. The mortality rate among cats with PTDM was 2.38 times the rate among cats that underwent renal transplantation but did not develop PTDM. Age, sex, body weight, and percentage change in body weight were not found to be significantly associ-ated with development of PTDM.
Conclusions and Clinical Relevance—Results suggest that cats that undergo renal transplantation have an increased risk of developing diabetes mellitus, compared with cats with chronic renal failure, and that mortality rate is higher for cats that develop PTDM than for cats that do not.