Objective—To evaluate the effects of 25% diet
restriction on life span of dogs and on markers of
Design—Paired feeding study.
Animals—48 Labrador Retrievers.
Procedures—Dogs were paired, and 1 dog in each
pair was fed 25% less food than its pair-mate from 8
weeks of age until death. Serum biochemical analyses
were performed, body condition was scored, and
body composition was measured annually until 12
years of age. Age at onset of chronic disease and
median (age when 50% of the dogs were deceased)
and maximum (age when 90% of the dogs were
deceased) life spans were evaluated.
Results—Compared with control dogs, food-restricted
dogs weighed less and had lower body fat content
and lower serum triglycerides, triiodothyronine,
insulin, and glucose concentrations. Median life span
was significantly longer for dogs in which food was
restricted. The onset of clinical signs of chronic disease
generally was delayed for food-restricted dogs.
Conclusions and Clinical Relevance—Results suggest
that 25% restriction in food intake increased
median life span and delayed the onset of signs of
chronic disease in these dogs. (J Am Vet Med Assoc