Objective—To determine effects of intraincisional
bioactive glass on healing of sutured skin wounds in
Animals—9 purpose-bred mature female Beagles.
Procedure—3 small matched bilateral (treated vs
control) full-thickness truncal skin incisions were
made and sutured. Treated wounds received intraincisional
particulate bioactive glass prior to closure.
Laser Doppler perfusion imaging was used to assess
percentage change in tissue perfusion 3 and 5 days
after incision on 1 set of 2 matched wounds, and skin
and subcutaneous tissue-cutaneous trunci breaking
strength were assessed at 5 days. The other 2 sets of
wounds were used for histologic evaluation at 5 and
21 days, respectively.
Results—Subjective signs of gross inflammatory
reaction were not detected in treated or control
wounds. At 5 days, median subcutaneous tissuecutaneous
trunci breaking strength was significantly
higher in treated wounds than in control wounds
(188.75 vs 75.00 g). At 5 days, median scores were
significantly higher for neutrophils (1 vs 0),
macrophages (2 vs 1), and necrosis (1 vs 0) for treated
wounds than for control wounds. At 21 days,
median macrophage scores were significantly higher
for treated wounds than for control wounds (2
Conclusions and Clinical Relevance—Bioactive
glass in soft tissues does not cause a gross inflammatory
reaction but causes an increase in histologic
signs of inflammation, which decreases with time.
Bioactive glass has potential for increasing tissue
strength. Increased subcutaneous breaking strength
could be beneficial in treating wounds in which early
healing strength is needed. (Am J Vet Res 2001;62:1149–1153)