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  • Author or Editor: Dez Hughes x
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We performed a study to determine a reference range for serum α1-antitrypsin (α1 at) in dogs by specific immunoassay; to evaluate whether serum α1 at concentration varied with age, sex, or reproductive status in healthy dogs; and to investigate whether the serum α1 at concentration in hospitalized dogs differed from that of healthy, nonhospitalized dogs. Serum α1 at was quantitated by radial gel immunodiffusion for 60 healthy dogs and 311 hospitalized dogs. In healthy dogs, serum α1 at concentration was 2.33 ± 0.41 mg/ml (mean ± sd), yielding a reference range (mean ± 2 sd) of 1.51 to 3.15 mg/ml. A correlation was not found between serum α1 at concentration and age in healthy dogs. The serum α1 at concentration (mean ± sem mg/ml) was significantly higher in healthy, sexually intact females (2.64 ± 0.1) than in healthy, spayed females (2.22 ± 0.12; P < 0.004); healthy, sexually intact males (2.14 ± 0.1; P < 0.0006); and healthy, castrated males (2.25 ± 0.14; P < 0.02). Hospitalized, sexually intact females had a lower serum α1 at concentration (1.93 ± 0.07) than healthy, sexually intact females (2.64 ± 0.1; P < 0.0002). Likewise, the serum α1 at concentration in hospitalized, sexually intact males (1.92 ± 0.04) was less than in healthy, sexually intact males (2.14 ± 0.1; P < 0.04). A difference in α1 at concentration was not found between healthy and hospitalized, neutered dogs.

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in American Journal of Veterinary Research