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Vaccination of dogs against rabies began with Louis Pasteur and his colleagues in 1884. 1 Mass vaccination of dogs against rabies, however, did not begin until 1919 with a phenol inactivated vaccine developed in Japan. 2 This same product was introduced for use in the United States in 1922. 3 Since then, various types of rabies vaccines for animal use have been licensed by the USDA CVB. These products are an important component of rabies control programs that have resulted in a substantial decline of rabies in dogs throughout the world and the elimination of canine variants

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in Journal of the American Veterinary Medical Association