Search Results

You are looking at 51 - 53 of 53 items for

  • Author or Editor: Kenneth W Hinchcliff x
  • Refine by Access: All Content x
Clear All Modify Search

Abstract

Objective—To determine the interobserver variability of assessment of exercise-induced pulmonary hemorrhage (EIPH) during tracheobronchoscopic examination in horses.

Animals—747 Thoroughbred racehorses.

Procedure—850 tracheobronchoscopic examinations were performed within 2 hours of racing for the horses. Examinations were recorded on videotape, and EIPH and its severity were assessed independently by 3 veterinarians. Concordance was determined by calculation of the Cohen weighted κ statistic and tabulation of scores assigned by each observer.

Results—Weighted κ statistics ranged from 0.75 to 0.80. In 99.4% of observations, all observers agreed or 2 of 3 agreed and the third differed by ≤ 1 grade.

Conclusions and Clinical Relevance—Results indicated that interobserver reliability of tracheobronchoscopic assessment of EIPH in Thoroughbred racehorses is high when the examination is conducted by experienced veterinarians. Concordance among investigators is sufficient to justify use of this grading system for further studies and clinical descriptions of EIPH. (Am J Vet Res 2005;66:596–598)

Full access
in American Journal of Veterinary Research

Abstract

Objective—To determine whether exercise-induced pulmonary hemorrhage (EIPH) was associated with racing performance in Thoroughbred horses not medicated with furosemide and not using nasal dilator strips.

Design—Observational cross-sectional study.

Animals—744 two- to 10-year-old Thoroughbred horses racing in Melbourne, Australia.

Procedure—Horses were enrolled prior to racing, and a tracheobronchoscopic examination was performed after 1 race. Examinations were recorded on videotape, and presence and severity (grade 0 to 4) of EIPH were subsequently determined by 3 observers blinded to the horses' identity. Race records were abstracted for each horse examined.

Results—Overall, 52.1% of horses eligible for participation in the study were examined, and horses that were examined did not differ from horses that were not examined in regard to age, sex distribution, or proportion of horses that won or finished in the first 3 positions. Horses with EIPH grades ≤ 1 were 4.0 times as likely to win, 1.8 times as likely to finish in the first 3 positions, and 3.03 times as likely to be in the 90th percentile or higher for race earnings as were horses with grades ≥ 2. Horses with EIPH grades ≥ 1 finished significantly farther behind the winner than did horses without EIPH. However, odds that horses with grade 1 EIPH would win or finish in the first 3 positions were not significantly different from odds for horses without EIPH.

Conclusions and Clinical Relevance—Results suggest that EIPH is associated with impaired performance in Thoroughbred racehorses not medicated with furosemide and not using nasal dilator strips. ( J Am Vet Med Assoc 2005;227:768–774)

Full access
in Journal of the American Veterinary Medical Association

Abstract

Objective—To determine the impact of successive days of endurance exercise on select serum chemistry values in conditioned Alaskan sled dogs.

Design—Prospective cohort study.

Animals—10 conditioned Alaskan sled dogs.

Procedures—All dogs ran 160 km/d for 5 consecutive days. Serum was obtained prior to exercise and immediately after each exercise run; all samples were obtained before dogs were fed. Serum electrolyte, mineral, protein, total bilirubin, urea nitrogen, creatinine, and cardiac troponin-I concentrations and serum alkaline phosphatase, alanine aminotransfer-ase, creatine kinase, and aspartate aminotransferase activities were measured. Data were analyzed by means of analysis of covariance for a randomized complete block design with dog as a blocking variable, time as a covariate, and distance run as the treatment of interest. Least square mean values were compared with values obtained prior to exercise, and linear and quadratic contrasts were examined.

Results—Serum globulin concentration was low prior to exercise (mean ± SD, 2.2 ± 0.3g/dL) and progressively decreased as exercise continued. Exercise was associated with increases in serum chloride, urea nitrogen, and cardiac troponin-I concentrations and serum alanine aminotransferase, creatine kinase, and aspartate aminotransferase activities and with pro-gressive decreases in serum potassium, total protein, and albumin concentrations.

Conclusions and Clinical Relevance—Results suggested that multiple successive days of endurance exercise resulted in mild aberrations in serum chemistry variables in conditioned sled dogs. Changes likely reflected the metabolic stresses of prolonged endurance exercise as well as dietary composition. Hypoglobulinemia in resting, conditioned sled dogs may reflect the immunosuppressive or catabolic effects of intense endurance training.

Full access
in Journal of the American Veterinary Medical Association