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Summary

Fibrin dots were induced in eyes of dogs by injection of autogenous citrated plasma into the anterior chamber. Twenty-four hours after dot formation, one 50-μl drop of tissue plasminogen activator at a concentration of 5 mg/ml (group 1, n = 7) was administered topically 9 times at 5-minute intervals, or a collagen shield that was hydrated with tissue plasminogen activator at a concentration of 5 mg/ml (group 2, n = 7) was applied. The contralateral eye served as a nontreated control. Serial photographs were taken of the fibrin dots after topical application of tissue plasminogen activator. Computerized morphometric analysis was then used to evaluate changes in cross-sectional surface area of the fibrin dot. There was no significant mean percentage decrease in dot surface area of treated eyes of group-1 dogs or in treated eyes of group-2 dogs. In addition, there was no significant difference in mean percentage decrease in dot surface area between treated eyes of group-1 and group-2 dogs.

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in American Journal of Veterinary Research
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in Journal of the American Veterinary Medical Association