Mattin MJ, Boswood A, Church DB, et al. Prevalence of and risk factors for degenerative mitral valve disease in dogs attending primary-care veterinary practices in England. J Vet Intern Med. 2015;29(3):847–854. doi:10.1111/jvim.12591
Häggström J, Boswood A, O’Grady M, et al. Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the QUEST study. J Vet Intern Med. 2008;22(5):1124–1135. doi:10.1111/j.1939–1676.2008.0150.x
de Madron E, King JN, Strehlau G, Valle White R. Survival and echocardiographic data in dogs with congestive heart failure caused by mitral valve disease and treated by multiple drugs: a retrospective study of 21 cases. Can Vet J. 2011;52(11):1219–1225.
Beaumier A, Rush JE, Yang VK, Freeman LM. Clinical findings and survival time in dogs with advanced heart failure. J Vet Intern Med. 2018;32(3):944–950. doi:10.1111/jvim.15126
Mizuno M, Yamano S, Chimura S, et al. Efficacy of pimobendan on survival and reoccurrence of pulmonary edema in canine congestive heart failure. J Vet Med Sci. 2017;79(1):29–34. doi:10.1292/jvms.16-0069
Markby GR, Summers KM, MacRae VE, Corcoran BM. Comparative transcriptomic profiling and gene expression for myxomatous mitral valve disease in the dog and human. Vet Sci. 2017;4(3):34 doi:10.3390/vetsci4030034
Ling H, Enriquez-Sarano M, Seward J, et al. Clinical outcome of mitral regurgitation due to flail leaflets. N Eng J Med. 1996;335(19):1417–1423. doi:10.1056/NEJM199611073351902
Seeburger J, Katus H, Pleger ST, Krumsdorf U, Mohr F-W, Bekeredjian R. Percutaneous and surgical treatment of mitral valve regurgitation. Dtsch Arztebl Int. 2011;108(48):816–821. doi:10.3238/arztebl.2011.0816
De Bonis M, Al-Attar N, Antunes M, et al. Surgical and interventional management of mitral valve regurgitation: a position statement from the European Society of Cardiology Working Groups on Cardiovascular Surgery and Valvular Heart Disease. Eur Heart J. 2016;37(2):133–139. doi:10.1093/eurheartj/ehv322
Uechi M, Mizukoshi T, Mizuno T, et al. Mitral valve repair under cardiopulmonary bypass in small breed dogs: 48 cases (2006–2009). J Am Vet Med Assoc. 2012;240(10):1194–1201. doi:10.2460/javma.240.10.1194
Bristow P, Tsumugi A. Repair of the myxomatous mitral valve: case selection and surgical technique. In: 2021 ACVIM Virtual Scientific Sessions Forum.
Keene BW, Atkins CE, Bonagura JD, et al. ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs. J Vet Intern Med. 2019;33(3):1127–1140. doi:10.1111/jvim.15488
Griffiths LG, Orton EC, Boon JA. Evaluation of techniques and outcomes of mitral valve repair in dogs. J Am Vet Med Assoc. 2004;224(12):1941–1945. doi:10.2460/javma.2004.224.1941
Mizuno T, Mizukoshi T, Uechi M. Long-term outcome in dogs undergoing mitral valve repair with suture annuloplasty and chordae tendinae replacement. J Small Anim Pract. 2013;54:104–107. doi:10.1111/j.1748-5827.2012.01305.x
Mellanby RJ, Herrtage ME, Dobson JM. Owners’ assessments of their dog’s quality of life during palliative chemotherapy for lymphoma. J Small Anim Pract. 2003;44:100–103. doi:10.1111/j.1748-5827.2003.tb00127.x
Wiseman-Orr ML, Scott EM, Reid J, Nolan AM. Validation of a structured questionnaire as an instrument to measure chronic pain in dogs on the basis of effects on health-related quality of life. Am J Vet Res. 2006;67(11):1826–1836. doi:10.2460/ajvr.67.11.1826
Budke CM, Levine JM, Kerwin SC, et al. Evaluation of a questionnaire for obtaining owner-perceived, weighted quality-of-life assessments for dogs with spinal cord injuries. J Am Vet Med Assoc. 2008;233(6):925–930. doi:org/10.2460/javma.233.6.925
Favrot C, Linek M, Mueller R, et al. Development of a questionnaire to assess the impact of atopic dermatitis on health-related quality of life of affected dogs and their owners. Vet Dermatol. 2010;21:64–70. doi:10.1111/j.1365-3164.2009.00781.x
Niessen SJ, Powney S, Guitian J, et al. Evaluation of a quality-of-life tool for cats with diabetes mellitus. J Vet Intern Med. 2010;24:1098–1105. doi:10.1111/j.1939-1676.2010.0579.x
German AJ, Holden SL, Wiseman-Orr ML, et al. Quality of life is reduced in obese dogs but improves after successful weight loss. Vet J. 2012;192:428–443. doi:10.1016/j.tvjl.2011.09.015
Niessen SJ, Powney S, Guitian J, et al. Evaluation of a quality-of-life tool for dogs with diabetes mellitus. J Vet Intern Med. 2012;26:953–961. doi:10.1111/j.1939-1676.2012.00947.x
Iliopoulou MA, Kitchell BE, Yuzbasiyan-Gurkan V. Development of a survey instrument to assess health-related quality of life in small animal cancer patients treated with chemotherapy. J Am Vet Med Assoc. 2013;242(12):1679–1687. doi:10.2460/javma.242.12.1679
Bristow P, Lipscomb V, Kummeling A, et al. Health-related quality of life following surgical attenuation of congenital portosystemic shunts versus healthy controls. J Small Anim Pract. 2019;60(1):21–26. doi:10.1111/jsap.12927
Schofield I, O’Neill DG, Brodbelt DC, et al. Development and evaluation of a health-related quality-of-life tool for dogs with Cushing’s syndrome. J Vet Intern Med. 2019;33:2595–2604. doi:10.1111/jvim.15639
Freeman LM, Rush JE, Farabaugh AE, et al. Development and evaluation of a questionnaire for assessing health-related quality of life in dogs with cardiac disease. J Am Vet Med Assoc. 2005;226(11):1864–1868. doi:10.2460/javma.2005.226.1864
Horner-Johnson W, Krahn G, Andresen E, et al. Developing summary scores of health-related quality of life for a population-based survey. Public Health Rep. 2009;124(1):103–110. doi:10.1177/003335490912400113
Westlake C, Dracup K, Creaser J. Correlates of health-related quality of life in patients with heart failure. Heart Lung. 2002;31(2):85–93. doi:10.1067/MHL.2002.122839
Chen H, Taichman D, Doyle R. Health-related quality of life and patient-reported outcomes in pulmonary arterial hypertension. Proc Am Thorac Soc. 2008;5(5):623–630. doi:10.1513/pats.200802-020SK
The IMPROVE Study Group. Acute and short-term hemodynamic, echocardiographic, and clinical effects of enalapril maleate in dogs with naturally acquired heart failure: results of the Invasive Multicenter PROspective Veterinary Evaluation of Enalapril study. J Vet Intern Med. 1995;9(4):234–242. doi:10.1111/j.1939-1676.1995.tb01074.x
Smith PJ, French AT, Van Israël N, et al. Efficacy and safety of pimobendan in canine heart failure caused by myxomatous mitral valve disease. J Small Anim Pract. 2005;46(3):121–130. doi:10.1111/jvim.14586
Lewis EF, Johnson PA, Johnson W, et al. Preferences for quality of life or survival expressed by patients with heart failure. J Heart Lung Transplant. 2001;20(9):1016–1024. doi:10.1016/s1053-2498(01)00298-4
Juenger J, Schellberg D, Kraemer S, et al. Health-related quality of life in patients with congestive heart failure: Comparison with other chronic diseases and relation to functional variables. Heart. 2002;87(3):235–241. doi:10.1136/heart.87.3.235
Riedinger MS, Dracup KA, Brecht ML. Quality of life in women with heart failure, normative groups, and patients with other chronic conditions. Am J Crit Care. 2002;11(3):211–219. doi:10.1016/j.hrtlng.2008.04.002
Oyama MA, Rush JE, O’Sullivan ML, et al. Perceptions and priorities of owners of dogs with heart disease regarding quality versus quantity of life for their pets. J Am Vet Med Assoc. 2008;233(1):104–108. doi:10.2460/javma.233.1.104
Reynolds CA, Oyama MA, Rush JE, et al. Perceptions of quality of life and priorities of owners of cats with heart disease. J Vet Intern Med. 2010;24(6):1421–1426. doi:10.1111/j.1939–1676.2010.0583.x
Williams C, Miller-Sonet E, Nipp R, et al. Importance of quality-of-life priorities and preferences surrounding treatment decision making in patients with cancer and oncology clinicians. Cancer. 2020;126(15):3534–3541. doi:10.1002/cncr.32961
International Small Animal Cardiac Health Council. Appendix 1: recommendations for the diagnosis of heart disease and treatment of heart failure in small animals. In: Tilley LP, Goodwin JK, eds. Manual of Canine and Feline Cardiology. 3rd ed. WB Saunders Co; 2001:459–489.
Ferasin L, Crews L, Biller DS, et al. Risk factors for coughing in dogs with naturally acquired myxomatous mitral valve disease. J Vet Intern Med. 2013;27(2):286–292. doi:10.1111/jvim.12039
Singh MK, Johnson LR, Kittleson MD, et al. Bronchomalacia in dogs with myxomatous mitral valve degeneration. J Vet Intern Med. 2012;26(2):312–319. doi:10.1111/j.1939–1676.2012.00887.x
Madaric J, Watripont P, Bartunek J, et al. Effect of mitral valve repair on exercise tolerance in asymptomatic patients with organic mitral regurgitation. Am Heart J. 2007;154(1):180–185. doi:10.1016/j.ahj.2007.03.051
Liu NC, Sargan DR, Adams VJ, Ladlow JF. Characterisation of brachycephalic obstructive airway syndrome in French Bulldogs using whole-body barometric plethysmography. PLoS One. 2015;10(6):e0130741. doi:10.1371/journal.pone.0130741
Ericksen V, Westlake C, Dracup K, et al. Sleep disturbance symptoms in patients with heart failure. AACN Adv Crit Care. 2003;14(4):477–487. doi:10.1097/00044067-200311000-00009
Randerath W, Deleanu O, Schiza S, Pepin J-L. Central sleep apnoea and periodic breathing in heart failure: prognostic significance and treatment options. Eur Respir Rev. 2019;28:190084. doi:10.1183/16000617.0084-2019
Köhnlein T, Welte T, Tan LB, Elliott MW. Central sleep apnoea syndrome in patients with chronic heart disease: a critical review of the current literature. Thorax. 2002;57(6):547–554. doi:10.1136/thorax.57.6.547
Whooley M. Depression and cardiovascular disease: healing the broken-hearted. J Am Med Assoc. 2006;295:2874–2881. doi:10.1001/jama.295.24.2874
Gottlieb SS, Khatta M, Friedmann E, et al. The influence of age, gender, and race on the prevalence of depression in heart failure patients. J Am Coll Cardiol. 2004;43(9):1542–1549. doi:10.1016/j.jacc.2003.10.064
Dekker RL, Peden AR, Lennie TA, Schooler MP, Moser DK. Living with depressive symptoms: patients with heart failure. Am J Crit Care. 2009;18(4):310–318. doi:10.4037/ajcc2009672
Zhao L, Kolm P, Borger MA, et al. Comparison of recovery after mitral valve repair and replacement. J Thorac Cardiovasc Surg. 2007;133(5):1257–1263. doi:10.1016/j.jtcvs.2006.12.048
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To determine changes in health-related quality of life up to 12 months after surgery in dogs with myxomatous mitral valve disease that undergo mitral valve repair.
54 dogs that underwent mitral valve repair at a United Kingdom referral hospital.
Health-related quality of life was assessed with a previously validated, owner-completed questionnaire before and 1, 3, 6, and 12 months after surgery.
There was a significant decrease in total score (corresponding to reduced negative impact of cardiac disease on quality of life) between the preoperative timepoint and all postoperative timepoints. A significant decrease in total score was also demonstrated between the 1- and 3-month timepoints, but no additional significant changes in total score between adjacent timepoints were identified beyond 3 months after surgery. Significant improvements in individual question scores were found up to 12 months after surgery.
Health-related quality of life was significantly improved following mitral valve repair in dogs with myxomatous mitral valve disease and this improvement persisted for up to a year after surgery. These results may be useful when counseling owners of dogs considered candidates for this procedure.