Cover Journal of the American Veterinary Medical Association
Journal of the American Veterinary Medical Association
ISSN:
0003-1488
Publication Date:
01 Dec 2022
  • 1.

    Jukes TH. Antibiotics in Nutrition. Medical Encyclopedia, Inc; 1955:128.

  • 2.

    Jones F, Ricke S. Observations on the history of the development of antimicrobials and their use in poultry feeds. Poult Sci. 2003;82(4):613–617. doi:10.1093/ps/82.4.613

    • Search Google Scholar
    • Export Citation
  • 3.

    Ainsworth GC, Austwick PKC. Response to the proposed amendments to the penicillin act. Vet Rec. 1953;65:166.

  • 4.

    Council for Agricultural Science and Technology. Antibiotics in Animal Feeds. Report No. 88. Council for Agricultural Science and Technology; 1981.

  • 5.

    CDC. Antibiotic Resistance Threats in the United States. US Department of Health and Human Services, CDC; 2019.

  • 6.

    Tang KL, Caffrey NP, Nobrega DB, et al. Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis. Lancet Planet Health. 2017;1:e316–e327. doi:10.1016/S2542-5196(17)30141-9

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    #152 Guidance for industry: evaluating the safety of antimicrobial new animal drugs with regard to their microbiological effects on bacteria of human health concern. US FDA. Department of Health and Human Services Center for Veterinary Medicine. Last modified October 23, 2003. Accessed June 12, 2022. https://www.fda.gov/media/69949/download

  • 8.

    #209 Guidance for industry: the judicious use of medically important antimicrobial drugs in food-producing animals. US FDA. Department of Health and Human Services Center for Veterinary Medicine. Last modified April 13, 2012. Accessed June 12, 2022. https://www.fda.gov/media/79140/download

    • PubMed
    • Export Citation
  • 9.

    Veterinary feed directive. Code of Federal Regulations. Last modified June 3, 2015. Accessed June 12, 2022. https://www.federalregister.gov/articles/2015/06/03/2015-13393/veterinary-feed-directive

    • PubMed
    • Export Citation
  • 10.

    Valid veterinarian–client–patient relationship. Code of Federal Regulations. Last modified January 3, 2017. Accessed June 12, 2022. https://www.ecfr.gov/current/title-21/chapter-I/subchapter-E/part-530/subpart-A/section-530.3#p-530.3(i)

    • PubMed
    • Export Citation
  • 11.

    Compliance Policy Guide: Sec. 615.115 Extralabel use of medicate feeds for minor species. US FDA. Department of Health and Human Services Center for Veterinary Medicine. Last modified December 2016. Accessed June 12, 2022. https://www.fda.gov/media/71960/download

  • 12.

    Simpson KE. Feeding tylosin in attempting to control liver abscesses. Master’s thesis. Texas Tech University; 1969.

  • 13.

    Feedlot 2011 Part IV: health and health management on US feedlots with a capacity of 1,000 or more head. USDA-APHIS-VS-CEAH-NAHMS. Last modified September 2013. Accessed June 12, 2022. https://www.aphis.usda.gov/animal_health/nahms/feedlot/downloads/feedlot2011/Feed11_dr_PartIV_1.pdf

  • 14.

    Wileman BW, Thomson DU, Reinhardt CD, Renter DG. Analysis of modern technologies commonly used in beef cattle production: conventional beef production versus nonconventional production using meta-analysis. J Anim Sci. 2009;87(10):3418–3426. doi:10.2527/jas.2009-1778

    • Search Google Scholar
    • Export Citation
  • 15.

    Supporting antimicrobial stewardship in veterinary settings: goals for fiscal years 2019–2023. US FDA. Department of Health and Human Services Center for Veterinary Medicine. Last modified September 2018. Accessed June 12, 2022. https://www.fda.gov/media/115776/download

  • 16.

    2020 Summary report on antimicrobials sold or distributed for use in food-producing animals. US FDA. Department of Health and Human Services Center for Veterinary Medicine. Last modified December 2021. Accessed June 12, 2022. https://www.fda.gov/media/154820/download

  • 17.

    Food animal residue avoidance and depletion species page. Accessed August 22, 2022. http://www.usfarad.org/treating-layers.html

  • 18.

    Singer RS, Porter LJ, Schrag NFD, Davies PR, Apley MD, Bjork K. Estimates of on-farm antimicrobial usage in broiler chicken production in the United States, 2013–2017. Zoonoses Public Health. 2020;67(suppl. 1):22–35. doi:10.1111/zph.12764

    • Search Google Scholar
    • Export Citation
  • 19.

    Singer RS, Porter LJ, Schrag NFD, Davies PR, Apley MD, Bjork K. Estimates of on-farm antimicrobial usage in turkey production in the United States, 2013–2017. Zoonoses Public Health. 2020;67(suppl. 1):36–50. doi:10.1111/zph.12763

    • Search Google Scholar
    • Export Citation
  • 20.

    Davies PR, Singer RS. Antimicrobial use in wean to market pigs in the United States assessed via voluntary sharing of proprietary data. Zoonoses Public Health. 2020;67(suppl. 1):6–21. doi:10.1111/zph.12760

    • Search Google Scholar
    • Export Citation

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Review of regulations and indications for the use of in-feed antimicrobials for production animals

Grant A. DewellDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA

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Christopher J. RademacherDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA

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Yuko SatoDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA

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DOI:
https://doi.org/10.2460/javma.22.07.0300
Volume/Issue:
Volume 260: Issue S3
Online Publication Date:
20 Sep 2022
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Abstract

Antimicrobials have been fed to livestock for more than 60 years. Veterinarians and producers saw tremendous gains in health and performance, and usage became widespread. Over time, improved management reduced some of the benefit of many feed-through antimicrobials except for a few important diseases. As a result of concerns about antimicrobial resistance, the US FDA restricted the use of medically important antimicrobials. Starting in 2017, medically important antimicrobials were restricted to therapeutic purposes only, and only under the order of a veterinarian. The aim of this review is to provide an overview of commonly used antimicrobials in livestock feed and regulatory changes regarding the veterinary feed directive. When used judiciously, in-feed antimicrobials are an important tool to ensure the health and welfare of food animals while preserving the effectiveness for animals and humans.

Abstract

Antimicrobials have been fed to livestock for more than 60 years. Veterinarians and producers saw tremendous gains in health and performance, and usage became widespread. Over time, improved management reduced some of the benefit of many feed-through antimicrobials except for a few important diseases. As a result of concerns about antimicrobial resistance, the US FDA restricted the use of medically important antimicrobials. Starting in 2017, medically important antimicrobials were restricted to therapeutic purposes only, and only under the order of a veterinarian. The aim of this review is to provide an overview of commonly used antimicrobials in livestock feed and regulatory changes regarding the veterinary feed directive. When used judiciously, in-feed antimicrobials are an important tool to ensure the health and welfare of food animals while preserving the effectiveness for animals and humans.

Contributor Notes

Corresponding author: Dr. Dewell (gdewell@iastate.edu)