• 1. Ogata N. Separation anxiety in dogs: what progress has been made in our understanding of the most common behavioral problems in dogs? J Vet Behav. 2016;16:2835.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2. Dreschel NA. The effects of fear and anxiety of health and lifespan in pet dogs. Appl Anim Behav Sci. 2010;125(3–4):157162.

  • 3. McCrave EA. Diagnostic criteria for separation anxiety in the dog. Vet Clin North Am Small Anim Pract. 1991;21(2):247255.

  • 4. Salman MD, Hutchison J, Ruch-Gallie R, et al. Behavior reasons for relinquishment of dogs and cats to 12 shelters. J Appl Anim Welf Sci. 2000;3(2):93106.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5. Bamberger M, Houpt KA. Signalment factors, comorbidity, and trends in behavior diagnoses in dogs: 1,644 cases (1991–2001). J Am Vet Med Assoc. 2006;229(10):15911601.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6. Li Y, vonHoldt B, Reynolds A, et al. Artificial selection on brain-expressed genes during the domestication of dog. Mol Biol Evol. 2013;30(8):18671876.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7. Prato-Previde E, Custance DM, Spiezio C, et al. Is the dog-human relationship an attachment bond? An observational study using Ainsworth's Strange Situation. Behaviour. 2003;140(2):225254.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8. Podberscek AL, Hsu Y, Serpell JA. Evaluation of clomipramine as an adjunct to behavioural therapy in the treatment of separation-related problems in dogs. Vet Rec. 1999;145(13):365369.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 9. Flannigan G, Dodman NH. Risk factors and behaviors associated with separation anxiety in dogs. J Am Vet Med Assoc. 2001;219(4):460466.

  • 10. Schwartz S. Separation anxiety syndrome in dogs and cats. J Am Vet Med Assoc. 2003;222(11):15261532.

  • 11. Overall KL. Manual of Clinical Behavioral Medicine for Cats and Dogs. Elsevier; 2013.

  • 12. Overall KL, Dunham AE, Frank D. Frequency of nonspecific clinical signs in dogs with separation anxiety, thunderstorm phobia, and noise phobia, alone or in combination. J Am Vet Med Assoc. 2001;219(4):467473.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13. Liebowitz MR, Fyer AJ, Gorman JM, et al. Specificity of lac-tate infusions in social phobia versus panic disorders. Am J Psychiatry. 1985;142(8):947950.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 14. Tiira K, Sulkama S, Lohi H. Prevalence, comorbidity, and behavioral variation in canine anxiety. J Vet Behav Clin Appl Res. 2016;16:3644.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 15. Salonen M, Mikkola S, Sulkama S, et al. Prevalence, comorbidity, and breed differences in canine anxiety in 13,700 Finnish pet dogs. Sci Rep. 2020;10(1):2962.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16. Dinwoodie IR, Dwyer B, Zottola V, et al. Demographics and comorbidity of behavior problems in dogs. J Vet Behav. 2019;32:6271.

  • 17. Bradshaw JWS, McPherson JA, Casey RA, et al. Aetiology of separation-related behaviour in domestic dogs. Vet Rec. 2002;151(2):4346.

  • 18. Bedford E. Number of US pet owning households by species 2019/20. Statistica. Accessed July 20, 2020. https://www.statista.com/statistics/198095/pets-in-the-united-states-by-type-in-2008/#:~:text=Over%2063%20million%20households%20in,the%20U.S.%20at%20this%20time

    • Search Google Scholar
    • Export Citation
  • 19. Sherman BL, Mills DS. Canine anxieties and phobias: An update on separation anxiety and noise aversions. Vet Clin North Am Small Anim Pract. 2008;38(5):10811106.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 20. Pet statistic. American Society for the Prevention of Cruelty to Animals. Accessed July 20, 2020. https://www.aspca.org/helping-people-pets/shelter-intake-and-surrender/pet-statistics#

    • Search Google Scholar
    • Export Citation
  • 21. Overall KL, Dunham AE, Juarbe-Diaz SV. Phenotypic determination of noise reactivity in 3 breeds of working dogs: A cautionary tale of age, breed, behavioral assessment, and genetics. J Vet Behav. 2016;16(16):113125.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 22. Overall KL, Dunham AE, Scheifele P, et al. Fear of noises affects problem solving behavior and locomotion in standardized cognitive tests. Appl Anim Behav Sci. 2019;221:104863. doi: https://doi.org/10.1016/j.applanim.2019.104863

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 23. Palestrini C, Minero M, Cannas S, Rossi E, Frank D. Video analysis of dogs with separation-related behaviours. Appl Anim Behav Sci 2010;124(1–2):6167.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 24. Lund JD, Jørgensen MC. Behaviour patterns and time course of activity in dogs with separation problems. Appl Anim Behav Sci. 1999;63(3):219236.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 25. Hammerle M, Horst C, Levine E, et al. 2015 AAHA canine and feline behavior management guidelines. J Am Anim Hosp Assoc. 2015;51(4):205221.

  • 26. Scaglia E, Cannas S, Minero M, Frank D, Bassi A, Palestrini C. Video analysis of adult dogs when left home alone. J Vet Behav. 2013;8(6):412417.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 27. Tiira K, Lohi H. Reliability and validity of a questionnaire survey in canine anxiety research. Appl Anim Behav Sci. 2014;155:8292.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 28. Tiira K, Lohi H. Early life experiences and exercise associate with canine anxieties. PLoS One. 2015;10(11):e0141907. doi: 10.1371/journal.pone.0141907

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 29. Bellamy KKL, Storengen LM, Handegård KW, et al. DRD2 is associated with fear in some dog breeds. J Vet Behav. 2018;27:6773.

  • 30. van Rooy D, Thomson PC, McGreevy PD, Wade CM. Risk factors of separation-related behaviours in Australian retrievers. Appl Anim Behav Sci. 2018;209:70.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 31. Storengen LM, Lingaas F. Noise sensitivity in 17 dog breeds: prevalence, breed risk and correlation with fear in other situations. Appl Anim Behav Sci. 2015;171:152160.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 32. McGreevy PD, Masters AM. Risk factors for separation-related distress and feed-related aggression in dogs: additional findings from a survey of Australian dog owners. Appl Anim Behav Sci. 2008;109(2–4):320328.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 33. Konok V, Marx A, Faragó T. Attachment styles in dogs and their relationship with separation-related disorder – a questionnaire based clustering. Appl Anim Behav Sci. 2019;213:8190.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 34. King JN, Simpson BS, Overall KL, et al. Treatment of separation anxiety in dogs with clomipramine: results from a prospective, randomized, double-blind, placebo-controlled, parallel-group, multicenter clinical trial. Appl Anim Behav Sci. 2000;67(6):255275.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 35. Pierantoni L, Albertini M, Pirrone F. Prevalence of owner-reported behaviours in dogs separated from the litter at two different ages. Vet Rec. 2011;169(18):468.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 36. González-Ramírez MT, Vanegas-Farfano M, Landero-Hernández R. Differences in stress and happiness between owners who perceive their dogs as well behaved or poorly behaved when they are left alone. J Vet Behav. 2018;28:15.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 37. Marston LC, Bennett PC. Reforging the bond—towards successful canine adoption. Appl Anim Behav Sci. 2003;83(3):227245.

  • 38. Pirrone F, Pierantoni L, Pastorino G, Albertini M. Owner-reported aggressive behavior towards familiar people may be a more prominent occurrence in pet shop-traded dogs. J Vet Behav. 2016;11:1317.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 39. McMillan FD, Serpell JA, Duffy DL, Masaoud E, Dohoo IR. Differences in behavioral characteristics between dogs obtained as puppies from pet stores and those obtained from noncommercial breeders. J Am Vet Med Assoc. 2013;242(10):13591363.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 40. Clark GI, Boyer WN. The effects of dog obedience training and behavioral counselling upon human–canine relationship. Appl Anim Behav Sci. 1993;37(2):147159.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 41. Takeuchi Y, Ogata N, Houpt KA, Scarlett JM. Differences in background and outcome of three behavior problems of dogs. Appl Anim Behav Sci. 2001;70(4):297308.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 42. Herron ME, Lord KL, Husseini SE. Effects of preadoption counseling on the prevention of separation anxiety in newly adopted shelter dogs. J Vet Behav. 2014;9(1):1321.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 43. Bennett PC, Rohlf VI. Owner-companion dog interactions: relationships between demographic variables, potentially problematic behaviours, training engagement and shared activities. Appl Anim Behav Sci. 2007;102(1–2):6584.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 44. Lofgren SE, Wiener P, Blott SC, et al. Management and personality in Labrador Retriever dogs. Appl Anim Behav Sci. 2014;156:4453.

  • 45. Mendl M, Brooks J, Basse C, et al. Dogs showing separation-related behaviour exhibit a ‘pessimistic' cognitive bias. Curr Biol. 2010;20(19):R839R840.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 46. Gosling SD. From mice to men: what can we learn about personality from animal research? Psychol Bull. 2001;127(1):4586.

  • 47. van Rooy D, Haase B, McGreevy PD, et al. Evaluating candidate genes oprm1, drd2, avpr1a, and oxtr in Golden Retrievers with separation-related behaviors. J Vet Behav. 2016;16:2227.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 48. Kwan JY, Bain MJ. Owner attachment and problem behaviors related to relinquishment and training techniques of dogs. J Appl Anim Welf Sci. 2013;16(2):168183.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 49. Parthasarathy V, Crowell-Davis SL. Relationship between attachment to owners and separation anxiety in pet dogs (Canis lupus familiaris). J Vet Behav. 2006;1(3):109120.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 50. Mariti C, Ricci E, Zilocchi M, Gazzano A. Owners as a secure base for their dogs. Behaviour. 2013;150(11):12751294.

  • 51. Mariti C, Carlone B, Ricci E, Sighieri C, Gazzano A. Intraspecific attachment in adult domestic dogs (Canis familiaris): preliminary results. Appl Anim Behav Sci. 2014;152:6472.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 52. Konok V, Doka A, Miklosi A. The behavior of the domestic dog (Canis familiaris) during separation from and reunion with the owner: a questionnaire and an experimental study. Appl Anim Behav Sci. 2011;135(4):300308.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 53. Konok V, Kosztolanyi A, Rainer W, Mutschler B, Halsband U, Miklósi Á. Influence of owners' attachment style and personality on their dogs' (Canis familiaris) separation-related disorder. PLoS One. 2015;10(2):e0118375.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 54. Mariti C, Carlone B, Protti M, Diverio S, Gazzano A. Effects of petting before a brief separation from the owner on dog behavior and physiology: a pilot study. J Vet Behav. 2018;27:4146.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 55. Yong MH, Ruffman T. Is that fear? Domestic dogs' use of social referencing signals from an unfamiliar person. Behav Processes. 2015;110:7481.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 56. Teixeira AR, Hall NJ. Effect of greeting and departure interactions on the development of increased separation related behaviors in newly adopted adult dogs. J Vet Behav. 2021;41:2232.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 57. D'Aniello B, Scandurra A, Alterisio A, Valsecchi P, Prato-Previde E. The importance of gestural communication: a study of human-dog communication using incongruent information. Anim Cogn. 2016;19(6):12311235.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 58. Kaminski J, Hynd J, Morris P, Waller BM. Human attention affects facial expressions in domestic dogs. Sci Rep. 2017;7(1):12914.

  • 59. Bryant DA, Dunham AE, Overall KL. Roles for referential focus in effective and efficient canine signaling: do pet and working dogs differ? J Vet Behav. 2018;27:5566.

    • Crossref
    • Search Google Scholar
    • Export Citation

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Review of epidemiological, pathological, genetic, and epigenetic factors that may contribute to the development of separation anxiety in dogs

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  • 1 From the Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI, Canada C1A 4P3.

Contributor Notes

Address correspondence to Dr. Overall (koverall@upei.ca).