• 1. Simpson KW. Inflammation. In: Washabau RJ, Day MJ, eds. Canine and feline gastroenterology. St Louis: Saunders, 2013;616619.

  • 2. Day MJ, Bilzer T, Mansell J, et al. Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group. J Comp Pathol 2008;138(suppl 1):S1S43.

    • Search Google Scholar
    • Export Citation
  • 3. van der Gaag I. The histological appearance of peroral gastric biopsies in clinically healthy and vomiting dogs. Can J Vet Res 1988;52:6774.

    • Search Google Scholar
    • Export Citation
  • 4. Poncet CM, Dupré GP, Freiche VG, et al. Prevalence of gastrointestinal tract lesions in 73 brachycephalic dogs with upper respiratory syndrome. J Small Anim Pract 2005;46:273279.

    • Search Google Scholar
    • Export Citation
  • 5. Simpson K, Neiger R, DeNovo R, et al. The relationship of Helicobacter spp. infection to gastric disease in dogs and cats. J Vet Intern Med 2000;14:223227.

    • Search Google Scholar
    • Export Citation
  • 6. Washabau RJ, Day MJ, Willard MD, et al. Endoscopic, biopsy, and histopathologic guidelines for the evaluation of gastrointestinal inflammation in companion animals. J Vet Intern Med 2010;24:1026.

    • Search Google Scholar
    • Export Citation
  • 7. Simpson KW. Diseases of the stomach. In: Ettinger SJ, Feldman EC, Côté E, eds. Textbook of veterinary internal medicine. 8th ed. St Louis: Elsevier, 2017;14951515.

    • Search Google Scholar
    • Export Citation
  • 8. Poncet CM, Dupré GP, Freiche VG, et al. Long-term results of upper respiratory syndrome surgery and gastrointestinal tract medical treatment in 51 brachycephalic dogs. J Small Anim Pract 2006;47:137142.

    • Search Google Scholar
    • Export Citation
  • 9. Kaye BM, Rutherford L, Perridge DJ, et al. Relationship between brachycephalic airway syndrome and gastrointestinal signs in three breeds of dog. J Small Anim Pract 2018;59:670673.

    • Search Google Scholar
    • Export Citation
  • 10. Reeve EJ, Sutton D, Friend EJ, et al. Documenting the prevalence of hiatal hernia and oesophageal abnormalities in brachycephalic dogs using fluoroscopy. J Small Anim Pract 2017;58:703708.

    • Search Google Scholar
    • Export Citation
  • 11. El-Serag H. The association between obesity and GERD: a review of the epidemiological evidence. Dig Dis Sci 2008;53:23072312.

  • 12. Mosing M, German AJ, Holden SL, et al. Oxygenation and ventilation characteristics in obese sedated dogs before and after weight loss: a clinical trial. Vet J 2013;198:367371.

    • Search Google Scholar
    • Export Citation
  • 13. Çolakoğlu , Börkü K, Haydardedeoğlu AE, et al. Correlation between endoscopic and histopathological findings in dogs with chronic gastritis. J Vet Res 2017;61:351355.

    • Search Google Scholar
    • Export Citation
  • 14. Elta GH, Appelman HD, Behler EM, et al. A study of the correlation between endoscopic and histological diagnoses in gastroduodenitis. Am J Gastroenterol 1987;82:749753.

    • Search Google Scholar
    • Export Citation
  • 15. Levy N, Stermer E, Boss JM. Accuracy of endoscopy in the diagnosis of inflamed gastric and duodenal mucosa. Isr J Med Sci 1985;21:564568.

    • Search Google Scholar
    • Export Citation
  • 16. Marchesi MC, Timpano CC, Busechian S, et al. The concordance between endoscopic and histological diagnosis in 114 dogs affected by gastric disease. Vet Ital 2017;53:309313.

    • Search Google Scholar
    • Export Citation
  • 17. Genta RM, Hamner HW. The significance of lymphoid follicles in the interpretation of gastric biopsy specimens. Arch Pathol Lab Med 1994;118:740743.

    • Search Google Scholar
    • Export Citation
  • 18. Rosh JR, Kurfist LA, Benkov KJ, et al. Helicobacter pylori and gastric lymphonodular hyperplasia in children. Am J Gastroenterol 1992;87:135139.

    • Search Google Scholar
    • Export Citation
  • 19. Simpson KW, McDonough PL, Strauss-Ayali D, et al. Helicobacter felis infection in dogs: effect on gastric structure and function. Vet Pathol 1999;36:237248.

    • Search Google Scholar
    • Export Citation
  • 20. Suárez-Esquivel M, Alfaro-Alarcón A, Guzmán-Verri C, et al. Analysis of the association between density of Helicobacter spp and gastric lesions in dogs. Am J Vet Res 2017;78:14141420.

    • Search Google Scholar
    • Export Citation
  • 21. Willard MD, Jergens AE, Duncan RB, et al. Interobserver variation among histopathologic evaluations of intestinal tissues from dogs and cats. J Am Vet Med Assoc 2002;220:11771182.

    • Search Google Scholar
    • Export Citation

Advertisement

Comparison of clinical, endoscopic, and histologic features between dogs with chronic gastritis with and without lymphofollicular hyperplasia

Mathieu R. Faucher DVM1, Vincent Biourge DVM, PhD2, Alexander J. German BVSc, PhD3, and Valérie Freiche DVM, PhD4
View More View Less
  • 1 1Department of Internal Medicine, Clinique Vétérinaire Alliance, 33300 Bordeaux, France.
  • | 2 2Royal Canin Research Center, 30470 Aimargues, France.
  • | 3 3Institute of Ageing and Chronic Disease and Institute of Veterinary Science, University of Liverpool, Neston CH64 7TE, England.
  • | 4 4Department of Internal Medicine, Université de Paris-Est, École Nationale Vétérinaire d'Alfort, 94704 Maisons-Alfort, France.

Abstract

OBJECTIVE

To compare clinical, endoscopic, and histopathologic features between dogs with chronic gastritis (CG) with and without lymphofollicular hyperplasia (LFH).

ANIMALS

64 and 56 dogs with CG with (cases) and without (controls) LFH, respectively.

PROCEDURES

The medical record database of a referral clinic was searched to identify dogs that underwent endoscopic examination of the upper portion of the gastrointestinal tract and were subsequently determined to have CG with or without LFH between October 2006 and February 2011. Signalment and clinical, endoscopic, and histologic findings were compared between cases and controls. Logistic regression was used to identify factors associated with CG with LFH.

RESULTS

Compared with controls, cases were significantly younger and more likely to be of a brachycephalic phenotype. The proportions of dogs with a poor body condition or diarrhea were significantly lower and the proportions of dogs with inspiratory dyspnea, exercise intolerance, or hyperemia and discoloration of the gastric mucosa were significantly higher for the case group, compared with the control group. Inspiratory dyspnea, gastric mucosal hyperemia, and gastritis severity were positively associated, whereas poor body condition was negatively associated, with CG with LFH on multivariable logistic regression.

CONCLUSIONS AND CLINICAL RELEVANCE

The strong positive association between inspiratory dyspnea and CG with LFH suggested that the condition may be a consequence of an increase in negative intrathoracic pressure rather than a distinct clinical entity. Prospective studies are warranted to elucidate the mechanism by which inspiratory dyspnea contributes to the development of CG with LFH.

Contributor Notes

Address correspondence to Dr. Faucher (m.faucher@veterinaire-alliance.fr).