Efficacy of intravenous administration of apomorphine for removal of gastric foreign material in dogs: 495 cases (2010–2015)

Kevin S. Kirchofer 1Ocean State Veterinary Specialists, 1480 S County Trail, East Greenwich, RI 02818.

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Gary Block 1Ocean State Veterinary Specialists, 1480 S County Trail, East Greenwich, RI 02818.

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Justine A. Johnson 1Ocean State Veterinary Specialists, 1480 S County Trail, East Greenwich, RI 02818.
1Ocean State Veterinary Specialists, 1480 S County Trail, East Greenwich, RI 02818.

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Abstract

OBJECTIVE

To evaluate the efficacy of IV administration of apomorphine for removal of gastric foreign bodies in dogs.

ANIMALS

495 dogs with gastric foreign bodies.

PROCEDURES

Records of a veterinary hospital were searched to identify dogs that received an injectable formulation of apomorphine between January 1, 2010, and July 30, 2015. Dogs with a gastric foreign body that received an IV injection of apomorphine were included in the study. Information extracted from the record of each dog included signalment, type of foreign material ingested, duration between foreign material ingestion and emesis, dose and number of doses of apomorphine administered, and whether emesis occurred and did or did not result in successful removal of the foreign body. Descriptive data were compared between dogs with and without successful foreign body removal.

RESULTS

Emesis with successful foreign body removal was achieved in 363 and 11 dogs after administration of 1 and 2 doses of apomorphine, respectively. Successful removal was more likely for young dogs and dogs that had ingested fabric, leather, or bathroom waste. Successful removal was less likely as the duration between foreign body ingestion and emesis increased and for dogs that received opioids, sedatives, or antiemetics before apomorphine administration. Minor adverse effects were recorded for only 4 dogs.

CONCLUSIONS AND CLINICAL RELEVLANCE

IV administration of apomorphine was a viable alternative for induction of emesis and removal of gastric foreign bodies in dogs. Dogs should be examined as soon as possible after foreign body ingestion and should not receive any medications that might affect apomorphine efficacy.

Abstract

OBJECTIVE

To evaluate the efficacy of IV administration of apomorphine for removal of gastric foreign bodies in dogs.

ANIMALS

495 dogs with gastric foreign bodies.

PROCEDURES

Records of a veterinary hospital were searched to identify dogs that received an injectable formulation of apomorphine between January 1, 2010, and July 30, 2015. Dogs with a gastric foreign body that received an IV injection of apomorphine were included in the study. Information extracted from the record of each dog included signalment, type of foreign material ingested, duration between foreign material ingestion and emesis, dose and number of doses of apomorphine administered, and whether emesis occurred and did or did not result in successful removal of the foreign body. Descriptive data were compared between dogs with and without successful foreign body removal.

RESULTS

Emesis with successful foreign body removal was achieved in 363 and 11 dogs after administration of 1 and 2 doses of apomorphine, respectively. Successful removal was more likely for young dogs and dogs that had ingested fabric, leather, or bathroom waste. Successful removal was less likely as the duration between foreign body ingestion and emesis increased and for dogs that received opioids, sedatives, or antiemetics before apomorphine administration. Minor adverse effects were recorded for only 4 dogs.

CONCLUSIONS AND CLINICAL RELEVLANCE

IV administration of apomorphine was a viable alternative for induction of emesis and removal of gastric foreign bodies in dogs. Dogs should be examined as soon as possible after foreign body ingestion and should not receive any medications that might affect apomorphine efficacy.

Contributor Notes

Dr. Kirchofer's present address is Affiliated Veterinary Specialists, 9905 S US Hwy 17–92, Maitland, FL 32751.

Address correspondence to Dr. Kirchofer (ksk7@cornell.edu).
  • 1. Harding RK, Hugenholtz H, Kucharczyk J, et al. Central mechanisms for apomorphine-induced emesis in the dog. Eur J Pharmacol 1987;144:6165.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2. Plumb DC. Plumb's veterinary drug handbook. 8th ed. Ames, Iowa: Wiley-Blackwell, 2015;7778.

  • 3. Depoortère R, Barret-Grévoz C, Bardin L, et al. Apomorphine-induced emesis in dogs: differential sensitivity to established and novel dopamine D2/5-HT(1A) antipsychotic compounds. Eur J Pharmacol 2008;597:3438.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4. Scherkl R, Hashem A, Frey HH. Apomorphine-induced emesis in the dog—routes of administration, efficacy and synergism by naloxone. J Vet Pharmacol Ther 1990;13:154158.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5. Khan SA, Mclean MK, Slater M, et al. Effectiveness and adverse effects of the use of apomorphine and 3% hydrogen peroxide solution to induce emesis in dogs. J Am Vet Med Assoc 2012;241:11791184.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6. Aronson LR, Brockman DJ, Brown DC. Gastrointestinal emergencies. Vet Clin North Am Small Anim Pract 2000;30:555579.

  • 7. Papazoglou LG, Patsikas MN, Rallis T. Intestinal foreign bodies in dogs and cats. Compend Contin Educ Pract Vet 2003;25:830844.

  • 8. Hayes G. Gastrointestinal foreign bodies in dogs and cats: a retrospective study of 208 cases. J Small Anim Pract 2009;50:576583.

  • 9. Boag AK, Coe RJ, Martinez TA, et al. Acid-base and electrolyte abnormalities in dogs with gastrointestinal foreign bodies. J Vet Intern Med 2005;19:816821.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 10. Cote DD, Collins DM, Burczynski FJ. Safety and efficacy of an ocular insert for apomorphine-induced emesis in dogs. Am J Vet Res 2008;69:13601365.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11. Wahlstrom D, Collins P, White T, et al. Developmental changes in dopamine neurotransmission in adolescence: behavioral implications and issues in assessment. Brain Cogn 2010;72:146159.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12. Giménez R, Raïch J, Aguilar J. Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice. Br J Pharmacol 1991;104:575578.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13. Bengtsson J, Ederoth P, Ley D, et al. The influence of age on the distribution of morphine and morphine-3-glucuronide across the blood-brain barrier in sheep. Br J Pharmacol 2009;157:10851096.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 14. Koh RB, Isaza N, Xie H, et al. Effects of maropitant, acepromazine, and electroacupuncture on vomiting associated with administration of morphine in dogs. J Am Vet Med Assoc 2014;244:820829.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 15. Valverde A, Cantwell S, Hernández J, et al. Effects of acepromazine on the incidence of vomiting associated with opioid administration in dogs. Vet Anaesth Analg 2004;31:4045.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16. Barnes NM, Bunce KT, Naylor RJ, et al. The actions of fentanyl to inhibit drug-induced emesis. Neuropharmacology 1991;30:10731083.

  • 17. Nelson OL, Jergens AE, Miles KG, et al. Gastric emptying as assessed by barium-impregnated polyethylene spheres in healthy dogs consuming a commercial kibble ration. J Am Anim Hosp Assoc 2001;37:444452.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 18. Hobday MM, Pachtinger GE, Drobatz KJ, et al. Linear versus non-linear gastrointestinal foreign bodies in 499 dogs: clinical presentation, management and short-term outcome. J Small Anim Pract 2014;55:560565.

    • Crossref
    • Search Google Scholar
    • Export Citation

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