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  • 1. Glass EN, Song RB, Kent M. Toxicosis in dogs associated with ointments containing fluorouracil (lett). J Am Vet Med Assoc 2019;254:787788.

    • Search Google Scholar
    • Export Citation
  • 2. Gustafson DL, Page RL. Cancer chemotherapy. In: Withrow SJ, Vail DM, Page RL, eds. Withrow and MacEwen's small animal clinical oncology. 5th ed. St Louis: Elsevier Saunders, 2013;157179.

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Letters to the Editor

Toxicosis in dogs associated with ointments containing 5-fluorouracil

We agree with Glass et al1 that more should be done to warn patients and physicians of the risks of 5-fluorouracil poisoning in pets.

The fatality rate in dogs with 5-fluorouracil toxicosis is reportedly as high as 48% to 64%.2,a,b Toxic signs include gastrointestinal and neurologic abnormalities followed by bone marrow suppression. However, bone marrow suppression is uncommonly seen because most animals with severe toxicosis do not survive long enough to develop hematologic effects.3

We have previously described 33 cases of 5-fluorouracil ingestion involving dogs