• 1. Weisbrode SE, Monke DR, Dodaro ST, et al. Osteochondrosis, degenerative joint disease, and vertebral osteophytosis in middle-aged bulls. J Am Vet Med Assoc 1982;181:700705.

    • Search Google Scholar
    • Export Citation
  • 2. Booth CJ, Warnick LD, Gröhn YT, et al. Effect of lameness on culling in dairy cows. J Dairy Sci 2004;87:41154122.

  • 3. Whitaker DA, Kelly JM, Smith S. Disposal and disease rates in 340 British dairy herds. Vet Rec 2000;146:363367.

  • 4. McLennan MW. Incidence of lameness requiring veterinary treatment in dairy cattle in Queensland. Aust Vet J 1988;65:144147.

  • 5. Russell AM, Rowlands GJ, Shaw SR, et al. Survey of lameness in British dairy cattle. Vet Rec 1982;111:155160.

  • 6. Pardon B, De Bleecker K, Hostens M, et al. Longitudinal study on morbidity and mortality in white veal calves in Belgium. BMC Vet Res 2012;8:26.

    • Search Google Scholar
    • Export Citation
  • 7. Svensson C, Lundborg K, Emanuelson U, et al. Morbidity in Swedish dairy calves from birth to 90 days of age and individual calf-level risk factors for infectious diseases. Prev Vet Med 2003;58:179197.

    • Search Google Scholar
    • Export Citation
  • 8. Hardy J. Etiology, diagnosis, and treatment of septic arthritis, osteitis, and osteomyelitis in foals. Clin Tech Equine Pract 2006;5:309317.

    • Search Google Scholar
    • Export Citation
  • 9. Weaver AD. Joint conditions. In: Greenough PR, Weaver AD, eds. Lameness in cattle. 3rd ed. Philadelphia: WB Saunders Co, 1997;162170.

    • Search Google Scholar
    • Export Citation
  • 10. Thrall DE. Radiographic features of bone tumors and bone infection. In: Textbook of veterinary diagnostic radiology. 6th ed. Raleigh: Elsevier Health Sciences, 2013;307318.

    • Search Google Scholar
    • Export Citation
  • 11. Rohde C, Anderson DE, Desrochers A, et al. Synovial fluid analysis in cattle: a review of 130 cases. Vet Surg 2000;29:341346.

  • 12. Lofstedt J, Dohoo IR, Duizer G. Model to predict septicemia in diarrheic calves. J Vet Intern Med 1999;13:8188.

  • 13. Al-Aubaidi JM, Fabricant J. The practical application of immunofluorescence (agar block technic) for the identification of Mycoplasma. Cornell Vet 1971;61:519542.

    • Search Google Scholar
    • Export Citation
  • 14. Gourlay RN, Howard CJ. Recovery and identification of bovine mycoplasmas. In: Tully JG, Razin S, eds. Methods in mycoplasmology. Vol. 2. New York: Academic Press, 1983;8189.

    • Search Google Scholar
    • Export Citation
  • 15. Qiagen Inc. Protocol: DNA purification from blood or body fluids (spin protocol). In: QIAamp, DNA mini and blood mini handbook. Valencia, Calif: Qiagen Inc, 2012; 2628.

    • Search Google Scholar
    • Export Citation
  • 16. Qiagen Inc. Protocol: PCR using the QIAGEN Fast Cycling PCR Kit. In: QIAGEN Fast Cycling Handbook. Valencia, Calif: Qiagen Inc, 2010;1417.

    • Search Google Scholar
    • Export Citation
  • 17. Subramaniam S, Bergonier D, Poumarat F, et al. Species identification of Mycoplasma bovis and Mycoplasma agalactiae based on the uvrC genes by PCR. Mol Cell Probes 1998;12:161169.

    • Search Google Scholar
    • Export Citation
  • 18. Jackson PG, Strachan WD, Tucker AW, et al. Treatment of septic arthritis in calves by joint lavage: a study of 20 cases. Cattle Pract 1998;108:281289.

    • Search Google Scholar
    • Export Citation
  • 19. Hepworth-Warren KL, Wong DM, Fulkerson CV, et al. Bacterial isolates, antimicrobial susceptibility patterns, and factors associated with infection and outcome in foals with septic arthritis: 83 cases (1998–2013). J Am Vet Med Assoc 2015;246:785793.

    • Search Google Scholar
    • Export Citation
  • 20. Vos NJ, Ducharme NG. Analysis of factors influencing prognosis in foals with septic arthritis. Ir Vet J 2008; 61:102106.

  • 21. Steiner A, Hirsbrunner G, Miserez R, et al. Arthroscopic lavage and implementation of gentamicin-impregnated collagen sponges for treatment of chronic septic arthritis in cattle. Vet Comp Orthop Traumatol 1999;12:2429.

    • Search Google Scholar
    • Export Citation
  • 22. Meier C. Procedure in purulent arthritis of adult cattle and clinical experience with joint lavage [in German]. Prakt Tierarzt 1997;78:893906.

    • Search Google Scholar
    • Export Citation
  • 23. Neil KM, Axon JE, Begg AP, et al. Retrospective study of 108 foals with septic osteomyelitis. Aust Vet J 2010;88:412.

  • 24. Roy JHB. The calf. 5th ed. Boston: Butterworths, 1990.

  • 25. Vasseur E, Borderas F, Cue RI, et al. A survey of dairy calf management practices in Canada that affect animal welfare. J Dairy Sci 2010;93:13071315.

    • Search Google Scholar
    • Export Citation
  • 26. Jensen MB. The effects of feeding method, milk allowance and social factors on milk feeding behaviour and cross-sucking in group housed dairy calves. Appl Anim Behav Sci 2003;80:191206.

    • Search Google Scholar
    • Export Citation
  • 27. Gruber BF, Miller BS, Onnen J, et al. Antibacterial properties of synovial fluid in the knee (Erratum published in J Knee Surg 2010;23:57). J Knee Surg 2008;21:180185.

    • Search Google Scholar
    • Export Citation
  • 28. Schneider RK, Bramlage LR, Moore RM, et al. A retrospective study of 192 horses affected with septic arthritis/tenosynovitis. Equine Vet J 1992;24:436442.

    • Search Google Scholar
    • Export Citation
  • 29. Goodarzi M, Khamesipour F, Mahallati SA, et al. Study on prevalence of bacterial causes in calves arthritis. Guangxi Nongye Shengwu Kexue 2015;10:206212.

    • Search Google Scholar
    • Export Citation
  • 30. von Essen R. Culture of joint specimens in bacterial arthritis. Impact of blood culture bottle utilization. Scand J Rheumatol 1997;26:293300.

    • Search Google Scholar
    • Export Citation
  • 31. Desrochers A, Francoz D. Clinical management of septic arthritis in cattle. Vet Clin North Am Food Anim Pract 2014;30:177203.

  • 32. Sanchez LC, Giguère S, Lester GD. Factors associated with survival of neonatal foals with bacteremia and racing performance of surviving Thoroughbreds: 423 cases (1982–2007). J Am Vet Med Assoc 2008;233:14461452.

    • Search Google Scholar
    • Export Citation
  • 33. Jost HB, Billington JS. Arcanobacterium pyogenes: molecular pathogenesis of an animal opportunist. Antonie Van Leeuwenhoek 2005; 88:87102.

    • Search Google Scholar
    • Export Citation
  • 34. Virtala AM, Mechor GD, Gröhn YT, et al. Morbidity from nonrespiratory diseases and mortality in dairy heifers during the first three months of life. J Am Vet Med Assoc 1996;208:20432046.

    • Search Google Scholar
    • Export Citation
  • 35. Miessa LC, Silva AA, Botteon RC, et al. Morbidity and mortality by umbilical cord inflammation in dairy calves. A Hora Veterinaria 2003;23:1618.

    • Search Google Scholar
    • Export Citation
  • 36. Wohlfender FD, Barrelet FE, Doherr MG, et al. Diseases in neonatal foals. Part 1: the 30-day incidence of disease and the effect of prophylactic antimicrobial drug treatment during the first three days postpartum. Equine Vet J 2009;41:179185.

    • Search Google Scholar
    • Export Citation
  • 37. Steel CM, Hunt AR, Adams PL, et al. Factors associated with prognosis for survival and athletic use in foals with septic arthritis: 93 cases (1987–1994). J Am Vet Med Assoc 1999;215:973977.

    • Search Google Scholar
    • Export Citation
  • 38. Marchionatti E, Nichols S, Babkine M, et al. Surgical management of omphalophlebitis and long-term outcome in calves: 39 cases (2008–2013). Vet Surg 2016;45:194200.

    • Search Google Scholar
    • Export Citation
  • 39. Goto Y, Murakami T, Koike A, et al. Bacteriological examination of umbilical infections in calves. Nippon Juishikai Zasshi 2003;56:528530.

    • Search Google Scholar
    • Export Citation
  • 40. Salci ESO, Salci H. Anatomo-physiological involution of umbilical cord, umbilical hygiene and etiopathogenesis of the umbilical lesions in calves. Res Opin Anim Vet Sci 2012;2:587590.

    • Search Google Scholar
    • Export Citation
  • 41. Stipkovits L, Rády M, Glávits R. Mycoplasmal arthritis and meningitis in calves. Acta Vet Hung 1993;41:7388.

  • 42. Butler JA, Sickles SA, Johanns CJ, et al. Pasteurization of discard mycoplasma mastitic milk used to feed calves: thermal effects on various mycoplasma. J Dairy Sci 2000;83:22852288.

    • Search Google Scholar
    • Export Citation
  • 43. Adegboye DS, Halbur PG, Nutsch RG, et al. Mycoplasma bovis–associated pneumonia and arthritis complicated with pyogranulomatous tenosynovitis in calves. J Am Vet Med Assoc 1996;209:647649.

    • Search Google Scholar
    • Export Citation
  • 44. Sachse K, Pfótzner H, Hotzel H, et al. Comparison of various diagnostic methods for the detection of Mycoplasma bovis. Rev Sci Tech 1993;12:571580.

    • Search Google Scholar
    • Export Citation
  • 45. Nicholas R, Baker S. Recovery of mycoplasmas from animals. In: Miles R, Nicholas R, eds. Mycoplasma protocols. New York: Humana Press, 1998;3743.

    • Search Google Scholar
    • Export Citation
  • 46. Cai HY, Bell-Rogers P, Parker L, et al. Development of a real-time PCR for detection of Mycoplasma bovis in bovine milk and lung samples. J Vet Diagn Invest 2005;17:537545.

    • Search Google Scholar
    • Export Citation
  • 47. Bell CJ, Blackburn P, Elliott M, et al. Investigation of polymerase chain reaction assays to improve detection of bacterial involvement in bovine respiratory disease. J Vet Diagn Invest 2014;26:631634.

    • Search Google Scholar
    • Export Citation
  • 48. Maunsell FP, Woolums AR, Francoz D, et al. Mycoplasma bovis infections in cattle. J Vet Intern Med 2011;25:772783.

  • 49. Francoz D, Fortin M, Fecteau G, et al. Determination of Mycoplasma bovis susceptibilities against six antimicrobial agents using the E test method. Vet Microbiol 2005;105:5764.

    • Search Google Scholar
    • Export Citation
  • 50. Pille F, Martens A, Oosterlinck M, et al. A retrospective study on 195 horses with contaminated and infected synovial cavities. Vlaams Diergeneeskundig Tijdschr 2009;78:97104.

    • Search Google Scholar
    • Export Citation
  • 51. Nade S. Septic arthritis. Best Pract Res Clin Rheumatol 2003;17:183200.

  • 52. Verschooten F, De Moor A, Steenhaut M, et al. Surgical and conservative treatment of infectious arthritis in cattle. J Am Vet Med Assoc 1974;165:271275.

    • Search Google Scholar
    • Export Citation

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Clinical findings and diagnostic test results for calves with septic arthritis: 64 cases (2009–2014)

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  • 1 Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.
  • | 2 Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.
  • | 3 Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.
  • | 4 Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.
  • | 5 Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.
  • | 6 Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.
  • | 7 Complexe de Diagnostic et d'Épidémiosurveillance Vétérinaires du Québec, Ministère de l'Agriculture, des Pěcheries et de l' Alimentation du Québec, St-Hyacinthe, QC J2S 7X9, Canada.
  • | 8 Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.

Abstract

OBJECTIVE To describe clinical findings and diagnostic test results and identify potential prognostic indicators for calves with septic arthritis.

DESIGN Retrospective case series.

ANIMALS 64 calves with septic arthritis.

PROCEDURES The medical record database for a veterinary teaching hospital was searched to identify calves ≤ 6 months old that were treated for septic arthritis between 2009 and 2014. Data evaluated included signalment, history, physical examination and diagnostic test results, treatment, and outcome. Descriptive data were generated, and calves were assigned to 2 groups (neonatal [≤ 28 days old] or postneonatal [29 to 180 days old]) on the basis of age at hospital admission for comparison purposes.

RESULTS 64 calves had 92 infected joints; 17 calves had polyarthritis. Carpal joints were most frequently affected followed by the stifle and tarsal joints. Forty-nine bacterial isolates were identified from synovial specimens for 38 calves, and the most commonly identified isolates were catalase-negative Streptococcus spp (n = 14) and Mycoplasma bovis (9). Calves in the neonatal group had a shorter interval between onset of clinical signs and hospitalization and were more likely to have an infected carpal joint than calves in the postneonatal group. Outcome was positive for 35 calves. Synovial fluid total nucleated cell count was positively associated with a positive outcome.

CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that empirical antimicrobial treatment for calves with septic arthritis should target gram-positive catalase-negative cocci and M bovis and that synovial fluid total nucleated cell count might be a useful prognostic indicator.

Abstract

OBJECTIVE To describe clinical findings and diagnostic test results and identify potential prognostic indicators for calves with septic arthritis.

DESIGN Retrospective case series.

ANIMALS 64 calves with septic arthritis.

PROCEDURES The medical record database for a veterinary teaching hospital was searched to identify calves ≤ 6 months old that were treated for septic arthritis between 2009 and 2014. Data evaluated included signalment, history, physical examination and diagnostic test results, treatment, and outcome. Descriptive data were generated, and calves were assigned to 2 groups (neonatal [≤ 28 days old] or postneonatal [29 to 180 days old]) on the basis of age at hospital admission for comparison purposes.

RESULTS 64 calves had 92 infected joints; 17 calves had polyarthritis. Carpal joints were most frequently affected followed by the stifle and tarsal joints. Forty-nine bacterial isolates were identified from synovial specimens for 38 calves, and the most commonly identified isolates were catalase-negative Streptococcus spp (n = 14) and Mycoplasma bovis (9). Calves in the neonatal group had a shorter interval between onset of clinical signs and hospitalization and were more likely to have an infected carpal joint than calves in the postneonatal group. Outcome was positive for 35 calves. Synovial fluid total nucleated cell count was positively associated with a positive outcome.

CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that empirical antimicrobial treatment for calves with septic arthritis should target gram-positive catalase-negative cocci and M bovis and that synovial fluid total nucleated cell count might be a useful prognostic indicator.

Contributor Notes

Address correspondence to Dr. Constant (caroline.constant@umontreal.ca).