• 1. Northrup NC, Selting KA, Rassnick KM, et al. Outcomes of cats with oral tumors treated with mandibulectomy: 42 cases. J Am Anim Hosp Assoc 2006; 42: 350360.

    • Search Google Scholar
    • Export Citation
  • 2. Boudrieau RJ, Tidwell AS, Ullman SL, et al. Correction of mandibular nonunion and malocclusion by plate fixation and autogenous cortical bone grafts in two dogs. J Am Vet Med Assoc 1994; 204: 744750.

    • Search Google Scholar
    • Export Citation
  • 3. Bracker KE, Trout NJ. Use of a free cortical ulnar autograft following en bloc resection of a mandibular tumor. J Am Anim Hosp Assoc 2000; 36: 7679.

    • Search Google Scholar
    • Export Citation
  • 4. Boudrieau RJ, Mitchell SL, Seeherman H. Mandibular reconstruction of a partial hemimandibulectomy in a dog with severe malocclusion. Vet Surg 2004; 33: 119130.

    • Search Google Scholar
    • Export Citation
  • 5. Spector DI, Keating JH, Boudrieau RJ. Immediate mandibular reconstruction of a 5 cm defect using rhBMP-2 after partial mandibulectomy in a dog. Vet Surg 2007; 36: 752759.

    • Search Google Scholar
    • Export Citation
  • 6. Lewis JR, Boudrieau RJ, Reiter AM, et al. Mandibular reconstruction after gunshot trauma in a dog by use of recombinant human bone morphogenetic protein. J Am Vet Med Assoc 2008; 233: 15981604.

    • Search Google Scholar
    • Export Citation
  • 7. Arzi B, Cissell DD, Pollard RE, et al. Regenerative approach to bilateral rostral mandibular reconstruction in a case series of dogs. Front Vet Sci 2015; 2: 47.

    • Search Google Scholar
    • Export Citation
  • 8. Moubayed SP, L'Heureux-Lebeau B, Christopoulos A, et al. Osteocutaneous free flaps for mandibular reconstruction: systematic review of their frequency of use and a preliminary quality of life comparison. J Laryngol Otol 2014; 128: 10341043.

    • Search Google Scholar
    • Export Citation
  • 9. Kokosis G, Schmitz R, Powers DB, et al. Mandibular reconstruction using the free vascularized fibula graft: an overview of different modifications. Arch Plast Surg 2016; 43: 39.

    • Search Google Scholar
    • Export Citation
  • 10. Zhang WB, Liang T, Peng X. Mandibular growth after paediatric mandibular reconstruction with the vascularized free fibula flap: a systematic review. Int J Oral Maxillofac Surg 2016; 45: 440447.

    • Search Google Scholar
    • Export Citation
  • 11. Sacco AG, Chepeha DB. Current status of transport-disc-distraction osteogenesis for mandibular reconstruction. Lancet Oncol 2007; 8: 323330.

    • Search Google Scholar
    • Export Citation
  • 12. Cohen A, Lavib A, Berman P, et al. Mandibular reconstruction using stereolithographic 3-dimensional printing modeling technology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108: 661666.

    • Search Google Scholar
    • Export Citation
  • 13. Salgueiro MI, Stevens MR. Experience with the use of prebent plates for the reconstruction of mandibular defects. Craniomaxillofac Trauma Reconstr 2010; 3: 201208.

    • Search Google Scholar
    • Export Citation
  • 14. Foley BD, Thayer WP, Honeybrook A, et al. Mandibular reconstruction using computer-aided design and computer-aided manufacturing: an analysis of surgical results. J Oral Maxillofac Surg 2013; 71: e111e119.

    • Search Google Scholar
    • Export Citation
  • 15. Azuma M, Yanagawa T, Ishibashi-Kanno N, et al. Mandibular reconstruction using plates prebent to fit rapid prototyping 3-dimensional printing models ameliorates contour deformity. Head Face Med 2014; 10: 4548.

    • Search Google Scholar
    • Export Citation
  • 16. Liu YF, Xu LW, Zhu HY, et al. Technical procedures for template-guided surgery for mandibular reconstruction based on digital design and manufacturing. Biomed Eng Online 2014; 13: 63.

    • Search Google Scholar
    • Export Citation
  • 17. Metzler P, Geiger EJ, Alcon A, et al. Three-dimensional virtual surgery accuracy for free fibular mandibular reconstruction: planned versus actual results. J Oral Maxillofac Surg 2014; 72: 26012612.

    • Search Google Scholar
    • Export Citation
  • 18. Steinbacher DM. Three-dimensional analysis and surgical planning in craniomaxillofacial surgery. J Oral Maxillofac Surg 2015; 73: S40S56.

    • Search Google Scholar
    • Export Citation
  • 19. Shan XF, Chen HM, Liang J, et al. Surgical navigation-assisted mandibular reconstruction with fibula flaps. Int J Oral Maxillofac Surg 2016; 45: 448453.

    • Search Google Scholar
    • Export Citation
  • 20. Tsai MJ, Wu CT. Study of mandible reconstruction using a fibula flap with application of additive manufacturing technology. Biomed Eng Online 2014; 13: 57.

    • Search Google Scholar
    • Export Citation
  • 21. Reiser V, Alterman M, Shuster A, et al. V-stand: a versatile surgical platform for oromandibular reconstruction using a 3-dimensional virtual modeling system. J Oral Maxillofac Surg 2015; 73: 12111226.

    • Search Google Scholar
    • Export Citation
  • 22. Wilde F, Cornelius CP, Schramm A. Computer-assisted mandibular reconstruction using a patient-specific reconstruction plate with computer-aided design and manufacturing techniques. Craniomaxillofac Trauma Reconstr 2014; 7: 158166.

    • Search Google Scholar
    • Export Citation
  • 23. Ferreira JJ, Zagalo CM, Oliveira ML, et al. Mandible reconstruction: history, state of the art and persistent problems. Prosthet Orthot Int 2015; 39: 182189.

    • Search Google Scholar
    • Export Citation
  • 24. Salisbury SK, Lantz GC. Long-term results of partial mandibulectomy for treatment of oral tumors in 30 dogs. J Am Anim Hosp Assoc 1988; 24: 285294.

    • Search Google Scholar
    • Export Citation
  • 25. Kosovsky JK, Matthiesen DT, Marretta SM, et al. Results of partial mandibulectomy for the treatment of oral tumors in 142 dogs. Vet Surg 1991; 20: 397401.

    • Search Google Scholar
    • Export Citation
  • 26. Schwarz PD, Withrow SJ, Curtis CR, et al. Mandibular resection as a treatment for oral cancer in 81 dogs. J Am Anim Hosp Assoc 1991; 27: 601610.

    • Search Google Scholar
    • Export Citation
  • 27. Fox LE, Geoghegan SL, Davis LH, et al. Owner satisfaction with partial mandibulectomy or maxillectomy for treatment of oral tumors in 27 dogs. J Am Anim Hosp Assoc 1997; 33: 2531.

    • Search Google Scholar
    • Export Citation
  • 28. Withrow SJ, Holmberg DL. Mandibulectomy in the treatment of oral cancer. J Am Anim Hosp Assoc 1983; 19: 273286.

  • 29. Bradley RL, MacEwen EG, Loar AS. Mandibular resection for removal of oral tumors in 30 dogs and 6 cats. J Am Vet Med Assoc 1984; 184: 460463.

    • Search Google Scholar
    • Export Citation
  • 30. White RAS, Gorman NT, Watkins SB, et al. The surgical management of bone-involved oral tumours in the dog. J Small Anim Pract 1985; 26: 693708.

    • Search Google Scholar
    • Export Citation
  • 31. Liu SK, Dorfman HD, Patnaik AK. Primary and secondary bone tumours in the cat. J Small Anim Pract 1974; 15: 141156.

  • 32. Turrel JM, Pool RR. Primary bone tumors in the cat: a retrospective study of 15 cats and a literature review. Vet Radiol Ultrasound 1982; 23: 152166.

    • Search Google Scholar
    • Export Citation
  • 33. Bitetto WV, Patnaik AK, Schrader SC, et al. Osteosarcoma in cats: 22 cases (1974–1984). J Am Vet Med Assoc 1987;190: 9193.

  • 34. Heldmann E, Anderson MA, Wagner-Mann C. Feline osteosarcoma: 145 cases (1990–1995). J Am Anim Hosp Assoc 2000;36: 518521.

  • 35. Straw RC, Powers BE, Klausner J, et al. Canine mandibular osteosarcoma: 51 cases (1980–1992). J Am Anim Hosp Assoc 1996;32: 257262.

    • Search Google Scholar
    • Export Citation
  • 36. Coyle VJ, Rassnick KM, Borst LB, et al. Biological behaviour of canine mandibular osteosarcoma a retrospective study of 50 cases (1997–2007). Vet Comp Oncol 2015;13: 8997.

    • Search Google Scholar
    • Export Citation
  • 37. Patnaik AK, Liu SK, Hurvitz AI, et al. Nonhematopoietic neoplasms in cats. J Natl Cancer Inst 1975; 54: 855860.

  • 38. Vos JH, van der Gaag I. Canine and feline oral-pharyngeal tumours. Zentralbl Veterinarmed A 1987; 34: 420427.

  • 39. Stebbins KE, Morse CC, Goldschmidt MH. Feline oral neoplasia: a ten year survey. Vet Pathol 1989; 26: 121128.

  • 40. Gendler A, Lewis JR, Reetz JA, et al. Computed tomographic features of oral squamous cell carcinoma in cats: 18 cases (2002–2008). J Am Vet Med Assoc 2010;236: 319325.

    • Search Google Scholar
    • Export Citation
  • 41. Goh BT, Lee S, Tideman H, et al. Mandibular reconstruction in adults: a review. Int J Oral Maxillofac Surg 2008; 37: 597605.

  • 42. Wong RC, Tideman H, Kin MA, et al. Biomechanics of mandibular reconstruction: a review. Int J Oral Maxillofac Surg 2010; 39: 313319.

    • Search Google Scholar
    • Export Citation
  • 43. Wong RC, Tideman H, Merkx MA, et al. Review of biomechanical models used in studying the biomechanics of reconstructed mandibles. Int J Oral Maxillofac Surg 2011; 40: 393400.

    • Search Google Scholar
    • Export Citation
  • 44. Bartaire E, Mouawad F, Mallet Y, et al. Morphologic assessment of mandibular reconstruction by free fibula flap and donor-site functional impairment in a series of 23 patients. Eur Ann Otorhinolaryngol Head Neck Dis 2012; 129: 230237.

    • Search Google Scholar
    • Export Citation
  • 45. Schlieve T, Almusa M, Miloro M, et al. Temporomandibular joint replacement for ankylosis correction in Nager Syndrome: case report and review of the literature. J Oral Maxillofac Surg 2012; 70: 616625.

    • Search Google Scholar
    • Export Citation
  • 46. Mercuri LG. A rationale for total alloplastic temporomandibular joint reconstruction in the management of idiopathic/progressive condylar resorption. J Oral Maxillofac Surg 2007; 65: 16001609.

    • Search Google Scholar
    • Export Citation
  • 47. Meomartino L, Fatone G, Brunetti A, et al. Temporomandibular ankylosis in the cat: a review of seven cases. J Small Anim Pract 1999; 40: 710.

    • Search Google Scholar
    • Export Citation
  • 48. Okumura M, Kadosawa T, Fujinaga T. Surgical correction of temporomandibular joint ankylosis in two cats. Aust Vet J 1999; 77: 2427.

    • Search Google Scholar
    • Export Citation
  • 49. Maas CP, Theyse LF. Temporomandibular joint ankylosis in cats and dogs: a report of 10 cases. Vet Comp Orthop Traumatol 2007; 20: 192197.

    • Search Google Scholar
    • Export Citation
  • 50. El-Warrak AO, Ferrer GA, Lanthier T, et al. Temporo-mandibular joint condylectomy and its effect over occlusion in cats: cadaveric study. J Small Anim Pract 2011; 52: 158162.

    • Search Google Scholar
    • Export Citation
  • 51. Boudrieau RJ. Maxillofacial fracture repair using miniplates and screws. In: Verstraete FJM, Lommer MJ, eds. Oral and maxillofacial surgery in dogs and cats. Philadelphia: Elsevier, 2012;296297.

    • Search Google Scholar
    • Export Citation
  • 52. Boudrieau RJ, Kudisch M. Miniplate fixation for repair of mandibular and maxillary fractures in 15 dogs and 3 cats. Vet Surg 1996; 25: 277291.

    • Search Google Scholar
    • Export Citation
  • 53. Verstraete FJM, Ligthelm AJ. Dental trauma caused by screws in internal fixation of mandibular osteotomies in the dog. Vet Comp Orthop Traumatol 1992; 5: 104108.

    • Search Google Scholar
    • Export Citation
  • 54. Tholen M, Hoyt RF. Oral pathology. In: Bojrab MJ, Tholen M, eds. Small animal oral medicine and surgery. Philadelphia: Lea and Febiger, 1990;2555.

    • Search Google Scholar
    • Export Citation
  • 55. Liptak JM, Dernell WS, Ehrhart N, et al. Cortical allograft and endoprosthesis for limb-sparing surgery in dogs with distal radial osteosarcoma: a prospective clinical comparison of two different limb-sparing techniques. Vet Surg 2006; 35: 518533.

    • Search Google Scholar
    • Export Citation
  • 56. Mitchell KE, Boston SE, Kung M, et al. Outcomes of limb-sparing surgery using two generations of metal endoprosthesis in 45 dogs with distal radial osteosarcoma: a Veterinary Society of Surgical Oncology retrospective study. Vet Surg 2016; 45: 3643.

    • Search Google Scholar
    • Export Citation
  • 57. Hummel DW, Lanz OI, Werre SR. Complications of cementless total hip replacement. A retrospective study of 163 cases. Vet Comp Orthop Traumatol 2010; 23: 424432.

    • Search Google Scholar
    • Export Citation
  • 58. Gemmill TJ, Pink J, Renwick A, et al. Hybrid cemented/cementless total hip replacement in dogs: seventy-eight consecutive joint replacements. Vet Surg 2011; 40: 621630.

    • Search Google Scholar
    • Export Citation
  • 59. Forster KE, Wills A, Torrington AM, et al. Complications and owner assessment of canine total hip replacement: a multicenter internet based survey. Vet Surg 2012; 41: 545550.

    • Search Google Scholar
    • Export Citation
  • 60. Vezzoni L, Vezzoni A, Boudrieau RJ. Long-term outcome of Zürich cementless total hip arthroplasty in 439 cases. Vet Surg 2015; 44: 921929.

    • Search Google Scholar
    • Export Citation
  • 61. Love DN, Vekselstein R, Collings S. The obligate and facultatively anaerobic bacterial flora of the normal feline gingival margin. Vet Microbiol 1990; 22: 267275.

    • Search Google Scholar
    • Export Citation
  • 62. Magaji AA, Saulawa MA, Salihu MD, et al. Oral microflora of stray domestic cats (Felis catus) found in the premises of two human hospitals in Sokoto, Nigeria. Sokoto J Vet Sci 2008; 7: 912.

    • Search Google Scholar
    • Export Citation
  • 63. Brahmachari S, Mandal SK, Das PK. Fabrication of SWCNT-Ag nanoparticle hybrid included self-assemblies for antibacterial applications. PLoS One 2014; 9: e106775.

    • Search Google Scholar
    • Export Citation
  • 64. Nooeaid P, Li W, Roether JA, et al. Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering and bone regeneration. Biointerphases 2014; 9: 041001.

    • Search Google Scholar
    • Export Citation
  • 65. Johnson CT, García AJ. Scaffold-based anti-infection strategies in bone repair. Ann Biomed Eng 2015; 43: 515528.

  • 66. Martínez-Vázquez FJ, Cabañas MV, Paris JL, et al. Fabrication of novel Si-doped hydroxyapatite/gelatin scaffolds by rapid prototyping for drug delivery and bone regeneration. Acta Biomater 2015; 15: 200209.

    • Search Google Scholar
    • Export Citation
  • 67. Wang YY, Chatzistavrou X, Faulk D, et al. Biological and bactericidal properties of Ag-doped bioactive glass in a natural extracellular matrix hydrogel with potential application in dentistry. Eur Cell Mater 2015; 29: 342355.

    • Search Google Scholar
    • Export Citation
  • 68. Zhu M, Li K, Zhu Y, et al. 3D-printed hierarchical scaffold for localized isoniazid/rifampin drug delivery and osteoarticular tuberculosis therapy. Acta Biomater 2015; 16: 145155.

    • Search Google Scholar
    • Export Citation

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Reconstruction of a mandibular segmental defect with a customized 3-dimensional–printed titanium prosthesis in a cat with a mandibular osteosarcoma

Julius M. Liptak BVSc, MVetClinStud1, Graham P. Thatcher DVM2, and Jonathan P. Bray MVSc, MSc3
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  • 1 VCA Canada Alta Vista Animal Hospital, 2616 Bank St, Ottawa, ON K1T 1M9, Canada.
  • | 2 VCA Canada Alta Vista Animal Hospital, 2616 Bank St, Ottawa, ON K1T 1M9, Canada.
  • | 3 Veterinary Teaching Hospital, Massey University, Palmerston North 4442, New Zealand.

Abstract

CASE DESCRIPTION A 12-year-old neutered male domestic shorthair cat had been treated for a mass arising from the lingual aspect of the caudal right mandibular body. Cytoreductive surgery of the mass had been performed twice over a 2-year period, but the mass recurred following both surgeries. The mass was diagnosed as an osteosarcoma, and the cat was referred for further evaluation and treatment.

CLINICAL FINDINGS Clinical findings were unremarkable, except for a 2-cm-diameter mass arising from the lingual aspect of the right mandible and mild anemia and lymphopenia. Pre- and postcontrast CT scans of the head, neck, and thorax were performed, revealing that the osteosarcoma was confined to the caudal right mandibular body, with no evidence of lymph node or pulmonary metastasis.

TREATMENT AND OUTCOME The stereolithographic files of the CT scan of the head were sent for computer-aided design and manufacture of a customized 3-D–printed titanium prosthesis. Segmental mandibulectomy was performed, and the mandibular defect was reconstructed in a single stage with the 3-D–printed titanium prosthesis. The cat had 1 minor postoperative complication but had no signs of eating difficulties at any point after surgery. The cat was alive and disease free 14 months postoperatively.

CLINICAL RELEVANCE Reconstruction of the mandible of a cat following mandibulectomy was possible with computer-aided design and manufacture of a customized 3-D–printed titanium prosthesis. Cats have a high rate of complications following mandibulectomy, and these initial findings suggested that mandibular reconstruction may reduce the risk of these complications and result in a better functional outcome.

Contributor Notes

Address correspondence to Dr. Liptak (animalcancersurgeon@icloud.com).