• 1. Alexander K, Dunn M, Carmel EN, et al. Clinical application of Patlak plot CT-GFR in animals with upper urinary tract disease. Vet Radiol Ultrasound 2010; 51:421427.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2. Alexander K, Del Castillo JR, Ybarra N, et al. Single-slice dynamic computed tomographic determination of glomerular filtration rate by use of Patlak plot analysis in anesthetized pigs. Am J Vet Res 2007; 68:297304.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3. Quesenberry K. Diseases of geriatric rabbits, in Proceedings. 1st Cong Vét Québécois 2013; 574604.

  • 4. Harcourt-Brown F. Update on Encephalitozoon cuniculi in pet rabbits. Exotic DVM 2004; 6:4144.

  • 5. Clauss M, Burger B, Liesegang A, et al. Influence of diet on calcium metabolism, tissue calcification and urinary sludge in rabbits (Oryctolagus cuniculus). J Anim Physiol Anim Nutr (Berl) 2012; 96:798807.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6. Sengupta S, Pal S, Biswas BK, et al. Fine-needle aspiration cytology of retroperitoneal lesions: a 5-year experience with an emphasis on cytohistological discrepancy. Acta Cytol 2014; 58:138144.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7. Harcourt-Brown FM. Diagnosis of renal diseases in rabbits. Vet Clin North Am Exot Anim Pract 2013; 16:145174.

  • 8. Brewer N, Cruise L. Physiology. In: Manning P, Ringler D, Newcomer C, eds. The biology of the laboratory rabbit. 2nd ed. San Diego: Academic Press, 1994; 6371.

    • Search Google Scholar
    • Export Citation
  • 9. Jenkins JR. Evaluation of the rabbit urinary tract. J Exot Pet Med 2010; 19:271279.

  • 10. Loeb WF, Quimbly FW. The clinical chemistry of laboratory animals. 2nd ed. Philadelphia: Taylor & Francis, 1999; 399454.

  • 11. Mellilo A. Rabbit clinical pathology. J Exot Pet Med 2007; 16:135145.

  • 12. O'Dell-Anderson KJ, Twardock R, Grimm JB, et al. Determination of glomerular filtration rate in dogs using contrast-enhanced computed tomography. Vet Radiol Ultrasound 2006; 47:127135.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13. Michigoshi Y, Yamagashi N, Satoh H, et al. Using a single blood sample and inulin to estimate glomerular filtration rate in rabbits. J Am Assoc Lab Anim Sci 2011; 50:702707.

    • Search Google Scholar
    • Export Citation
  • 14. Jabarian V, Assadnassab G, Oskoi SD, et al. Measurement of rabbit's glomerular filtration rate (GFR) by scintigraphy. Eur J Exp Biol 2012; 5:15451549.

    • Search Google Scholar
    • Export Citation
  • 15. Annet L, Hermoye L, Peeters F, et al. Glomerular filtration rate: assessment with dynamic contrast-enhanced MRI and a cortical-compartment model in the rabbit kidney. J Magn Reson Imaging 2004; 20:843849.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16. Zhang YD, Wang J, Zhang J, et al. Effect of iodinated contrast media on renal function evaluated with dynamic three-dimensional MR renography. Radiology 2014; 270:409415.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 17. Dawson P. Functional imaging in CT. Eur J Radiol 2006; 60:331340.

  • 18. Kerl ME, Cook CR. Glomerular filtration rate and renal scintigraphy. Clin Tech Small Anim Pract 2005; 20:3138.

  • 19. Morris TW, Fischer HW. The pharmacology of intravascular radiocontrast media. Annu Rev Pharmacol Toxicol 1986; 26:143160.

  • 20. Lerman LO, Rodriguez-Porcel M, Romero JC. The development of X-ray imaging to study renal function. Kidney Int 1999; 55:400416.

  • 21. Tsushima Y. Functional CT of the kidney. Eur J Radiol 1999; 30:191197.

  • 22. Alexander K, Authier S, Del Castillo JR, et al. Patlak plot analysis CT-GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs. Contrast Media Mol Imaging 2010; 5:133139.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 23. Chang J, Kim S, Jung J, et al. Assessment of glomerular filtration rate with dynamic computed tomography in normal Beagle dogs. J Vet Sci 2011; 12:393399.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 24. Granger LA, Armbrust LJ, Rankin DC, et al. Estimation of glomerular filtration rate in healthy cats using single-slice dynamic CT and Patlak plot analysis. Vet Radiol Ultrasound 2012; 53:181188.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 25. Chang J, Ahn S, Choi S, et al. Evaluation of glomerular filtration rate by use of dynamic computed tomography and Patlak analysis in clinically normal cats. Am J Vet Res 2011; 72:12761282.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 26. Alexander K, Ybarra N, Del Castillo JR, et al. Determination of glomerular filtration rate in anesthetized pigs by use of three-phase whole-kidney computed tomography and Patlak plot analysis. Am J Vet Res 2008; 69:14551462.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 27. Karsner HT, Straus R, Moore RA, et al. Urea tolerance after unilateral nephrectomy in rabbits. J Exp Med 1932; 55:2730.

  • 28. Chapman D, Moore R, Klarenbach S, et al. Residual renal function after partial or radical nephrectomy for renal cell carcinoma. Can Urol Assoc J 2010; 4:337343.

    • Search Google Scholar
    • Export Citation
  • 29. Von Hendy-Willson VE, Pressler BM. Overview of glomerular filtration rate testing in dog and cats. Vet J 2011; 188:156165.

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Glomerular filtration rate determination by computed tomography in two pet rabbits with renal disease

Graham ZollerDepartment of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, QC J2S 7C6, Canada.

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Isabelle LangloisDepartment of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, QC J2S 7C6, Canada.

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Kate AlexanderDepartment of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, QC J2S 7C6, Canada.

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Abstract

CASE DESCRIPTION A 3-year-old and a 7-year-old spayed female rabbit (Oryctolagus cuniculus) were evaluated because of digestive stasis associated with renal asymmetry.

CLINICAL FINDINGS Neoplasia of the right kidney was diagnosed via cytologic analysis in the 3-year-old rabbit. Ureterolithiasis of the left kidney was diagnosed via abdominal ultrasonography in the 7-year-old rabbit. To evaluate whether unilateral nephrectomy was indicated, evaluation of glomerular filtration rate by dynamic CT (CT-GFR) was performed on both rabbits. On the basis of the functional and morphological CT-GFR results, radical nephrectomy was recommended for the rabbit with renal neoplasia whereas a more conservative approach was recommended for the other rabbit.

TREATMENT AND OUTCOME The rabbit with renal neoplasia underwent radical nephrectomy without complication. The rabbit with ureterolithiasis underwent ureteral stent placement, and the renal pelvic dilatation resolved. Both rabbits maintained unremarkable serum urea and creatinine concentrations after surgery.

CLINICAL RELEVANCE GFR is a highly useful and reliable variable for the evaluation of renal function but is difficult to assess with routine clinical laboratory tests. The CT-GFR technique described here was quickly performed, was technically suitable for rabbits, and provided clinically relevant information. Studies are required to establish reference values for CT-GFR in rabbits.

Abstract

CASE DESCRIPTION A 3-year-old and a 7-year-old spayed female rabbit (Oryctolagus cuniculus) were evaluated because of digestive stasis associated with renal asymmetry.

CLINICAL FINDINGS Neoplasia of the right kidney was diagnosed via cytologic analysis in the 3-year-old rabbit. Ureterolithiasis of the left kidney was diagnosed via abdominal ultrasonography in the 7-year-old rabbit. To evaluate whether unilateral nephrectomy was indicated, evaluation of glomerular filtration rate by dynamic CT (CT-GFR) was performed on both rabbits. On the basis of the functional and morphological CT-GFR results, radical nephrectomy was recommended for the rabbit with renal neoplasia whereas a more conservative approach was recommended for the other rabbit.

TREATMENT AND OUTCOME The rabbit with renal neoplasia underwent radical nephrectomy without complication. The rabbit with ureterolithiasis underwent ureteral stent placement, and the renal pelvic dilatation resolved. Both rabbits maintained unremarkable serum urea and creatinine concentrations after surgery.

CLINICAL RELEVANCE GFR is a highly useful and reliable variable for the evaluation of renal function but is difficult to assess with routine clinical laboratory tests. The CT-GFR technique described here was quickly performed, was technically suitable for rabbits, and provided clinically relevant information. Studies are required to establish reference values for CT-GFR in rabbits.

Contributor Notes

Dr. Zoller's present address is Exotics Department, Centre Hospitalier Vétérinaire Frégis, 43 Ave Aristide Briand, 94110 Arcueil, France.

Dr. Alexander's present address is Centre vétérinaire DMV, 2300 54th Ave, Lachine, QC H8T 3R2, Canada.

Address correspondence to Dr. Langlois (isabelle.langlois@umontreal.ca).