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A 9-year-old 41-kg (90.2-lb) spayed female German Shepherd Dog was evaluated because of weight loss (2 kg [4.4 lb] over a 3-month period) and an 11-day history of polydipsia and polyuria. The dog had previously received intermittent treatment with stilbestrol for urinary incontinence and meloxicam for bilateral stifle joint osteoarthritis secondary to cranial cruciate ligament disease.
Physical examination revealed signs of mild discomfort on palpation over the kidneys. A CBC, serum biochemical analysis, and urinalysis revealed moderate leukocytosis (38.9 × 103 WBCs/μL; reference interval, 6 × 103 WBCs/μL to 17
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