1. George LW, Divers TJ, Mahaffey EA, et al. Heinz body anemia and methemoglobinemia in ponies given red maple (Acer rubrum) leaves. Vet Pathol 1982; 19:521–533.
2. Tennant B, Dill SG, Glickman LT, et al. Acute hemolytic anemia, methemoglobinemia, and Heinz body formation associated with ingestion of red maple leaves by horses. J Am Vet Med Assoc 1981; 179:143–150.
3. Carlson GP. Disorders of the hematopoietic and hemolymphatic systems. In: Smith BP, ed. Large animal internal medicine. 3rd ed. St Louis: Mosby, 2002;1039–1084.
4. Weber M. Miller, RE. Presumptive red maple (Acer rubrum) toxicosis in Grevy's zebra (Equus grevyi). J Zoo Wildl Med 1997; 28:105–108.
5. DeWitt SF, Bedenice D, Mazan MR. Hemolysis and Heinz body formation associated with ingestion of red maple leaves in two alpacas. J Am Vet Med Assoc 2004; 225:578–583.
6. Boyer JD, Breeden DC, Brown DL. Isolation, identification, and characterization of compounds from Acer rubrum capable of oxidizing equine erythrocytes. Am J Vet Res 2002; 63:604–610.
7. Agrawal K, Ebel JG, Altier C, et al. Identification of protoxins and a microbial basis for red maple (Acer rubrum) toxicosis in equines. J Vet Diagn Invest 2013; 25:112–119.
8. Stockham SL, Scott MA. Erythrocytes. In: Fundamentals of veterinary clinical pathology. 2nd ed. Ames, Iowa: Blackwell Publishing, 2008;107–222.
9. Desnoyers M. Anemias associated with oxidative injury. In: Weiss DJ, Wardrop KJ, eds. Schalm's veterinary hematology. 6th ed. Ames, Iowa: Wiley-Blackwell, 2010;239–245.
10. Smith JE, Beutler E. 3. Am J Physiol 1966; 210:347–350.
11. Robin H, Harley JD. Regulation of methaemoglobinaemia in horse and human erythrocytes. Aust J Exp Biol Med Sci 1967; 45:77–88.
12. Alward A, Corriher CA, Barton MH, et al. Red maple (Acer rubrum) leaf toxicosis in horses: a retrospective study of 32 cases. J Vet Intern Med 2006; 20:1197–1201.
13. Plumlee KH. Red maple toxicity in a horse. Vet Hum Toxicol 1991; 33:66–67.
14. Haymond SH, Cariappa R, Eby CS, et al. Laboratory assessment of oxygenation in methemoglobinemia. Clin Chem 2005; 51:434–444.
15. Ham TH, Grauel JA, Dunn RF, et al. Physical properties of red cells as related to effects in vivo. IV. Oxidant drugs producing abnormal intracellular concentration of hemoglobin (eccentrocytes) with a rigid-red-cell hemolytic syndrome. J Lab Clin Med 1973; 82:898–910.
16. Stockham SL, Scott MA. Urinary system. In: Fundamentals of veterinary clinical pathology. 2nd ed. Ames, Iowa: Blackwell Publishing, 2008;415–494.
17. McConnico RS, Brownie CF. The use of ascorbic acid in the treatment of 2 cases of red maple (Acer rubrum)-poisoned horses. Cornell Vet 1992; 82:293–300.
18. Stair EL, Edwards WC, Burrows GE, et al. Suspected red maple (Acer rubrum) toxicosis with abortion in two Percheron mares. Vet Hum Toxicol 1993; 35:229–230.
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Dr. Weinstein's present address is Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104. Dr. Gilsenan's present address is Rood & Riddle Equine Hospital, 2150 Georgetown Rd, Lexington, KY 40511.
1. George LW, Divers TJ, Mahaffey EA, et al. Heinz body anemia and methemoglobinemia in ponies given red maple (Acer rubrum) leaves. Vet Pathol 1982; 19:521–533.
2. Tennant B, Dill SG, Glickman LT, et al. Acute hemolytic anemia, methemoglobinemia, and Heinz body formation associated with ingestion of red maple leaves by horses. J Am Vet Med Assoc 1981; 179:143–150.
3. Carlson GP. Disorders of the hematopoietic and hemolymphatic systems. In: Smith BP, ed. Large animal internal medicine. 3rd ed. St Louis: Mosby, 2002;1039–1084.
4. Weber M. Miller, RE. Presumptive red maple (Acer rubrum) toxicosis in Grevy's zebra (Equus grevyi). J Zoo Wildl Med 1997; 28:105–108.
5. DeWitt SF, Bedenice D, Mazan MR. Hemolysis and Heinz body formation associated with ingestion of red maple leaves in two alpacas. J Am Vet Med Assoc 2004; 225:578–583.
6. Boyer JD, Breeden DC, Brown DL. Isolation, identification, and characterization of compounds from Acer rubrum capable of oxidizing equine erythrocytes. Am J Vet Res 2002; 63:604–610.
7. Agrawal K, Ebel JG, Altier C, et al. Identification of protoxins and a microbial basis for red maple (Acer rubrum) toxicosis in equines. J Vet Diagn Invest 2013; 25:112–119.
8. Stockham SL, Scott MA. Erythrocytes. In: Fundamentals of veterinary clinical pathology. 2nd ed. Ames, Iowa: Blackwell Publishing, 2008;107–222.
9. Desnoyers M. Anemias associated with oxidative injury. In: Weiss DJ, Wardrop KJ, eds. Schalm's veterinary hematology. 6th ed. Ames, Iowa: Wiley-Blackwell, 2010;239–245.
10. Smith JE, Beutler E. 3. Am J Physiol 1966; 210:347–350.
11. Robin H, Harley JD. Regulation of methaemoglobinaemia in horse and human erythrocytes. Aust J Exp Biol Med Sci 1967; 45:77–88.
12. Alward A, Corriher CA, Barton MH, et al. Red maple (Acer rubrum) leaf toxicosis in horses: a retrospective study of 32 cases. J Vet Intern Med 2006; 20:1197–1201.
13. Plumlee KH. Red maple toxicity in a horse. Vet Hum Toxicol 1991; 33:66–67.
14. Haymond SH, Cariappa R, Eby CS, et al. Laboratory assessment of oxygenation in methemoglobinemia. Clin Chem 2005; 51:434–444.
15. Ham TH, Grauel JA, Dunn RF, et al. Physical properties of red cells as related to effects in vivo. IV. Oxidant drugs producing abnormal intracellular concentration of hemoglobin (eccentrocytes) with a rigid-red-cell hemolytic syndrome. J Lab Clin Med 1973; 82:898–910.
16. Stockham SL, Scott MA. Urinary system. In: Fundamentals of veterinary clinical pathology. 2nd ed. Ames, Iowa: Blackwell Publishing, 2008;415–494.
17. McConnico RS, Brownie CF. The use of ascorbic acid in the treatment of 2 cases of red maple (Acer rubrum)-poisoned horses. Cornell Vet 1992; 82:293–300.
18. Stair EL, Edwards WC, Burrows GE, et al. Suspected red maple (Acer rubrum) toxicosis with abortion in two Percheron mares. Vet Hum Toxicol 1993; 35:229–230.
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