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A 12-year-old 9.1-kg (20-lb) neutered male Scottish Terrier was evaluated because of a 3-month history of vomiting, anorexia, and lethargy. Four weeks prior, the dog underwent exploratory laparotomy, during which diffuse thickening of the gastric wall and splenomegaly were noted. A splenectomy was performed, and pancreatic, hepatic, gastric, and intestinal biopsy specimens were obtained. Splenic extramedullary hematopoiesis was diagnosed; no other abnormalities were detected in the remaining organs and no clinical improvement was noticed after provision of supportive care (subcutaneous fluid therapy and administration of glucocorticoids).
At the referral evaluation, the dog had signs of