• 1. Santos LCLudders JW. Erb HN, et al. A randomized, blinded, controlled trial of the antiemetic effect of ondansetron on dexmedetomidine-induced emesis in cats. Vet Anaesth Analg 2011;38:320327.

    • Search Google Scholar
    • Export Citation
  • 2. Robertson SAWegner KLascelles BD. Antinociceptive and side-effects of hydromorphone after subcutaneous administration in cats. J Feline Med Surg 2009;11:7681.

    • Search Google Scholar
    • Export Citation
  • 3. Kolahian SJarolmasjed S. Effects of metoclopramide on emesis in cats sedated with xylazine hydrochloride. J Feline Med Surg 2010;12:899903.

    • Search Google Scholar
    • Export Citation
  • 4. Hay Kraus BL. Efficacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone. Vet Anaesth Analg 2013;40:2834.

    • Search Google Scholar
    • Export Citation
  • 5. Claude AKDedeaux AChiavaccini L, et al. Effects of maropitant citrate or acepromazine on the incidence of adverse events associated with hydromorphone premedication in dogs. J Vet Intern Med 2014;28:14141417.

    • Search Google Scholar
    • Export Citation
  • 6. Cerenia [package insert]. New York, NY: Pfizer Animal Health, 2012.

  • 7. Scholz JSteinfath MTonner PH. Antiemetics. In: Evers ASMaze M, eds. Anesthetic pharmacology: physiologic principles and clinical practice (a companion to Miller's anesthesia). 7th ed. Edinburgh: Churchill Livingstone, 2004;777791.

    • Search Google Scholar
    • Export Citation
  • 8. Ho CMHo STWang JJ, et al. Effects of dexamethasone on emesis in cats sedated with xylazine hydrochloride. Am J Vet Res 2001;62:12181221.

    • Search Google Scholar
    • Export Citation
  • 9. Kolahian SJarolmasjed SH. Antiemetic efficacy of promethazine on xylazine-induced emesis in cats. Can Vet J 2012;53:193195.

  • 10. Hay Kraus BL. Effect of dosing interval on efficacy of maropitant for prevention of hydromorphone-induced vomiting and signs of nausea in dogs. J Am Vet Med Assoc 2014;245:10151020.

    • Search Google Scholar
    • Export Citation
  • 11. Johnson RA. Maropitant prevented vomiting but not gastroesophageal reflux in anesthetized dogs premedicated with acepromazine-hydromorphone. Vet Anaesth Analg 2014;41:406410.

    • Search Google Scholar
    • Export Citation

Advertisement

Effects of maropitant in cats receiving dexmedetomidine and morphine

View More View Less
  • 1 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
  • | 2 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
  • | 3 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
  • | 4 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
  • | 5 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
  • | 6 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
  • | 7 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
  • | 8 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

Abstract

OBJECTIVE To evaluate the effects of maropitant in cats receiving dexmedetomidine and morphine.

DESIGN Randomized controlled trial.

ANIMALS 66 healthy female domestic shorthair cats.

PROCEDURES Cats were randomly assigned to receive maropitant (1 mg/kg [0.45 mg/lb], SC; maropitant group; n = 32) or saline (0.9% NaCl) solution (0.1 mL/kg [0.045 mL/lb], SC; control group; 34) 20 hours before IM administration of dexmedetomidine (20 μg/kg [9.1 μg/lb]) and morphine (0.1 mg/kg). Following administration of dexmedetomidine and morphine, the incidences of emesis, retching, and signs of nausea (sialorrhea and lip licking) were compared between the 2 groups. The aversive behavioral response of each cat to injection of maropitant or saline solution was scored on a visual analogue scale by each of 4 observers who were unaware of the treatment administered.

RESULTS Only 1 of 32 cats in the maropitant group vomited, whereas 20 of 34 control cats vomited. The incidences of emesis and retching for the maropitant group were significantly lower than those for the control group. The incidence of signs of nausea did not differ between the 2 groups. Visual analogue scale scores for the maropitant group were significantly higher than those for the control group.

CONCLUSIONS AND CLINICAL RELEVANCE Results of the present study indicated that administration of maropitant to healthy cats approximately 20 hours prior to administration of dexmedetomidine and morphine significantly decreased the incidence of emesis but did not decrease the incidence of signs of nausea. However, maropitant appeared to cause substantial discomfort when injected SC.

Contributor Notes

Address correspondence to Dr. Martin-Flores (martinflores@cornell.edu).