1. German AJ. The growing problem of obesity in dogs and cats. J Nutr 2006; 136: 1940S–1946S.
2. Courcier EA, Thomson RM, Mellor DJ, et al. An epidemiological study of environmental factors associated with canine obesity. J Small Anim Pract 2010; 51: 362–367.
3. McGreevy PD, Thomson PC, Pride C, et al. Prevalence of obesity in dogs examined by Australian veterinary practices and the risk factors involved. Vet Rec 2005; 156: 695–702.
4. Lund EM, Armstrong PJ, Kirk CA, et al. Prevalence and risk factors for obesity in adult dogs from private US veterinary practices. Int J Appl Res Vet Med 2006; 4: 177–186.
5. Kealy RD, Lawler DF, Ballam JM, et al. Effects of diet restriction on life span and age-related changes in dogs. J Am Vet Med Assoc 2002; 220: 1315–1320.
6. Laflamme DP. Understanding and managing obesity in dogs and cats. Vet Clin North Am Small Anim Pract 2006; 36: 1283–1295.
7. Toll PW, Yamka RM, Schoenherr WD, et al. Obesity. In: Hand M, Thatcher C, Remillard R, et al, eds. Small animal clinical nutrition. 5th ed. Topeka, Kan: Mark Morris Institute, 2010; 501–542.
8. German AJ, Hervera M, Hunter L, et al. Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs. Domest Anim Endocrinol 2009; 37: 214–226.
9. Wakshlag JJ, Struble AM, Levine CB, et al. The effects of weight loss on adipokines and markers of inflammation in dogs. Br J Nutr 2011; 106 (suppl 1):S11–S14.
10. German AJ, Holden SL, Bissot T, et al. Dietary energy restriction and successful weight loss in obese client-owned dogs. J Vet Intern Med 2007; 21: 1174–1180.
11. Butterwick RF, Hawthorne AJ. Advances in dietary management of obesity in dogs and cats. J Nutr 1998; 128: 2771S–2775S.
12. Linder DE, Freeman LM, Morris P, et al. Theoretical evaluation of risk for nutritional deficiency with caloric restriction in dogs. Vet Q 2012; 32: 123–129.
13. Linder DE, Freeman LM. Evaluation of calorie density and feeding directions for commercially available diets designed for weight loss in dogs and cats. J Am Vet Med Assoc 2010; 236: 74–77.
14. Blanchard G, Nguyen P, Gayet C, et al. Rapid weight loss with a high-protein low-energy diet allows the recovery of ideal body composition and insulin sensitivity in obese dogs. J Nutr 2004; 134: 2148S–2150S.
15. Burkholder WJ, Bauer JE. Foods and techniques for managing obesity in companion animals. J Am Vet Med Assoc 1998; 212: 658–662.
16. German AJ, Holden SL, Bissot T, et al. A high protein high fibre diet improves weight loss in obese dogs. Vet J 2010; 183: 294–297.
17. St-Onge MP, Jones PJH. Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. J Nutr 2002; 132: 329–332.
18. Hall JA, Jewell DE. Feeding healthy Beagles medium-chain triglycerides, fish oil, and carnitine offsets age-related changes in serum fatty acids and carnitine metabolites. PLoS ONE [serial online] 2012; 7: e49510. Available at: journals.plos.org/plosone/article?id=10.1371/journal.pone.0049510. Accessed Jun 26, 2013.
19. Paetau-Robinson I, Yamka RM, Friesen KG. Foods with lipoic acid and elevated levels of vitamin E and vitamin C correlate with whole blood antioxidant concentrations and may protect geriatric dogs from oxidative stress. Int J Appl Res Vet Med 2008; 6: 93–100.
20. Reeder T, Hibbard G, McLeod KR, et al. Dietary lysine: calorie ratios and their influence on nitrogen metabolism and digestibility in moderately obese mature dogs. Am J Anim Vet Sci 2011; 6: 45–54.
21. Garlick PJ. The role of leucine in the regulation of protein metabolism. J Nutr 2005; 135: 1553S–1556S.
22. Jewell DE, Toll PW. Effects of fiber on food intake in dogs. Vet Clin Nutr 1996; 3: 115–118.
23. Thatcher CD, Hand MS, Remillard RL. Small animal clinical nutrition: an iterative process. In: Hand M, Thatcher C, Remillard R, et al, eds. Small animal clinical nutrition. 5th ed. Topeka, Kan: Mark Morris Institute, 2010; 6.
24. Darden T. AAFCO official publication. Champaign, Ill: Association of American Feed Control Officials, 2013; 180.
25. Hall JA, Melendez LD, Jewell DE. Using gross energy improves metabolizable energy predictive equations for pet foods whereas undigested protein and fiber content predict stool quality. PLoS ONE [serial online] 2013; 8: e54405. Available at: dx.plos.org/10.1371/journal.pone.0054405. Accessed Nov 12, 2013.
26. National Research Council. Nutrient requirements of dogs and cats. Washington, DC: The National Academies Press, 2006; 31–359.
27. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 2003; 100: 9440–9445.
28. Papamandjaris AA, MacDougall DE, Jones PJH. Minireview—medium chain fatty acid metabolism and energy expenditure: obesity treatment implications. Life Sci 1998; 62: 1203–1215.
29. Böttger I, Dobbs R, Faloona GR, et al. The effects of triglyceride absorption upon glucagon, insulin and gut glucagon-like immunoreactivity. J Clin Invest 1973; 52: 2532–2541.
30. Dlasková A, Spacek T, Skobisová E, et al. Certain aspects of uncoupling due to mitochondrial uncoupling proteins in vitro and in vivo. Biochim Biophys Acta 2006; 1757: 467–473.
31. Ibrahim WH, Bailey N, Sunvold GD, et al. Effects of carnitine and taurine on fatty acid metabolism and lipid accumulation in the liver of cats during weight gain and weight loss. Am J Vet Res 2003; 64: 1265–1277.
32. Reed LJ. Multienzyme complexes. Acc Chem Res 1974; 7: 40–46.
33. Ames BN. Micronutrients prevent cancer and delay aging. Toxicol Lett 1998; 102–103:5–18.
34. Zhang WJ, Wei H, Hagen T, et al. Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Proc Natl Acad Sci U S A 2007; 104: 4077–4082.
35. Sola S, Mir MQ, Cheema FA, et al. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. Circulation 2005; 111: 343–348.
36. Eason RC, Archer HE, Akhtar S, et al. Lipoic acid increases glucose uptake by skeletal muscles of obese-diabetic ob/ob mice. Diabetes Obes Metab 2002; 4: 29–35.
37. Moschen AR, Molnar C, Geiger S, et al. Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression. Gut 2010; 59: 1259–1264.
38. Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006; 6: 772–783.
39. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011; 29: 415–445.
40. Sonta T, Inoguchi T, Tsubouchi H, et al. Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity. Free Radic Biol Med 2004; 37: 115–123.
41. Urakawa H, Katsuki A, Sumida Y, et al. Oxidative stress is associated with adiposity and insulin resistance in men. J Clin Endocrinol Metab 2003; 88: 4673–4676.
42. Tanner AE, Martin J, Thatcher CD, et al. Nutritional amelioration of oxidative stress induced by obesity and acute weight loss. Compend Contin Educ Pract Vet 2006; 28 (suppl 4):72.
43. Yamka RM, Frantz NZ, Friesen KG. Effects of 3 canine weight loss foods on body composition and obesity markers. Int J Appl Res Vet Med 2007; 5: 125–132.
44. Millward DJ, Layman DK, Tome D, et al. Protein quality assessment: impact of expanding understanding of protein and amino acid needs for optimal health. Am J Clin Nutr 2008; 87 (suppl):1576S–1581S.
45. Jewell DE, Toll PW, Novotny BJ. Satiety reduces adiposity in dogs. Vet Ther 2000; 1: 17–23.
46. Jewell DE, Toll PW, Azain MJ, et al. Fiber but not conjugated linoleic acid influences adiposity in dogs. Vet Ther 2006; 7: 78–85.
47. Jeusette IC, Detilleux J, Shibata H, et al. Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs. Res Vet Sci 2005; 79: 169–175.
48. Jeusette IC, Lhoest ET, Istasse LP, et al. Influence of obesity on plasma lipid and lipoprotein concentrations in dogs. Am J Vet Res 2005; 66: 81–86.
49. Diez M, Michaux C, Jeusette I, et al. Evolution of blood parameters during weight loss in experimental obese Beagle dogs. J Anim Physiol Anim Nutr (Berl) 2004; 88: 166–171.
50. Peña C, Suárez L, Bautista I, et al. Relationship between analytic values and canine obesity. J Anim Physiol Anim Nutr (Berl) 2008; 92: 324–325.
51. Tvarijonaviciute A, Ceron JJ, Holden SL, et al. Obesity-related metabolic dysfunction in dogs: a comparison with human metabolic syndrome. BMC Vet Res 2012; 8: 147.
52. Yamka RM, Friesen KG, Frantz NZ. Identification of canine markers related to obesity and the effects of weight loss on the markers of interest. Int J Appl Res Vet Med 2006; 4: 282–292.
53. Katan MB, Zock PL, Mensink RP. Effects of fats and fatty acids on blood lipids in humans: an overview. Am J Clin Nutr 1994; 60 (suppl):1017S–1022S.
54. Mero AA, Ojala T, Hulmi JJ, et al. Effects of alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes. J Int Soc Sports Nutr 2010; 7: 1.
55. Lang CH, Pruznak A, Navaratnarajah M, et al. Chronic α-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy. Am J Physiol Endocrinol Metab 2013; 305: E416–E428.
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Objective—To determine the effect of feeding a food with coconut oil and supplemental l-carnitine, lipoic acid, lysine, leucine, and fiber on weight loss and maintenance in dogs.
Design—Prospective clinical study
Animals—50 overweight dogs.
Procedures—The study consisted of 2 trials. During trial 1, 30 dogs were allocated to 3 groups (10 dogs/group) to be fed a dry maintenance dog food to maintain body weight (group 1) or a dry test food at the same amount on a mass (group 2) or energy (group 3) basis as group 1. During trial 2, each of 20 dogs was fed the test food and caloric intake was adjusted to maintain a weight loss rate of 1% to 2%/wk (weight loss phase). Next, each dog was fed the test food in an amount calculated to maintain the body weight achieved at the end of the weight loss phase (weight maintenance phase). Dogs were weighed and underwent dual-energy x-ray absorptiometry monthly. Metabolomic data were determined before (baseline) and after each phase.
Results—During trial 1, dogs in groups 2 and 3 lost significantly more weight than did those in group 1. During trial 2, dogs lost a significant amount of body weight and fat mass but retained lean body mass (LBM) during the weight loss phase and continued to lose body fat but gained LBM during the weight maintenance phase. Evaluation of metabolomic data suggested that fat metabolism and LBM retention were improved from baseline for dogs fed the test food.
Conclusions and Clinical Relevance—Results suggested that feeding overweight dogs the test food caused weight loss and improvements in body condition during the weight-maintenance phase, possibly because the food composition improved energy metabolism.
Dr. Hahn's present address is NextSource Biotechnology, 3024 SW Wanamaker Rd, No. 204, Topeka, KS 66614.
Supported by Hill's Pet Nutrition Inc.
All authors were employees of Hill's Pet Nutrition at the time the work was completed.
Presented in part at the American College of Veterinary Internal Medicine Forum, Seattle, June 2013; and the American College of Veterinary Internal Medicine Forum, Nashville, Tenn, June 2014.