• 1. von Praun F, Matiasek K, Grevel V, et al. Magnetic resonance imaging and pathologic findings associated with necrotizing encephalitis in two Yorkshire Terriers. Vet Radiol Ultrasound 2006; 47: 260264.

    • Search Google Scholar
    • Export Citation
  • 2. Lezmi S, Toussaint Y, Prata D, et al. Severe necrotizing encephalitis in a Yorkshire Terrier: topographic and immunohistochemical study. J Vet Med A Physiol Pathol Clin Med 2007; 54: 186190.

    • Search Google Scholar
    • Export Citation
  • 3. Kuwamura M, Adachi T, Yamate J, et al. Necrotising encephalitis in the Yorkshire Terrier: a case report and literature review. J Small Anim Pract 2002; 43: 459463.

    • Search Google Scholar
    • Export Citation
  • 4. Spitzbarth I, Schenk H, Tipold A, et al. Immunohistochemical characterization of inflammatory and glial responses in a case of necrotizing leukoencephalitis in a French Bulldog. J Comp Pathol 2010; 142: 235241.

    • Search Google Scholar
    • Export Citation
  • 5. Talarico LR, Schatzberg SJ. Idiopathic granulomatous and necrotising inflammatory disorders of the canine central nervous system: a review and future perspectives. J Small Anim Pract 2010; 51: 138149.

    • Search Google Scholar
    • Export Citation
  • 6. Tipold A, Fatzer R, Jaggy A. Necrotizing encephalitis in Yorkshire Terriers. J Small Anim Pract 1993; 34: 623628.

  • 7. Timmann D, Konar M, Howard J, et al. Necrotizing encephalitis in a French Bulldog. J Small Anim Pract 2007; 48: 339342.

  • 8. Schatzberg SJ, Haley NJ, Barr SC, et al. Polymerase chain reaction screening for DNA viruses in paraffin-embedded brains from dogs with necrotizing meningoencephalitis, necrotizing leukoencephalitis, and granulomatous meningoencephalitis. J Vet Intern Med 2005; 19: 553559.

    • Search Google Scholar
    • Export Citation
  • 9. Park ES, Uchida K, Nakayama H. Comprehensive immunohistochemical studies on canine necrotizing meningoencephalitis (NME), necrotizing leukoencephalitis (NLE), and granulomatous meningoencephalitis (GME). Vet Pathol 2012; 49: 682692.

    • Search Google Scholar
    • Export Citation
  • 10. Jung DI, Kang BT, Park C, et al. A comparison of combination therapy (cyclosporine plus prednisolone) with sole prednisolone therapy in 7 dogs with necrotizing meningoencephalitis. J Vet Med Sci 2007; 69: 13031306.

    • Search Google Scholar
    • Export Citation
  • 11. Shibuya M, Matsuki N, Fujiwara K, et al. Autoantibodies against glial fibrillary acidic protein (GFAP) in cerebrospinal fluids from Pug dogs with necrotizing meningoencephalitis. J Vet Med Sci 2007; 69: 241245.

    • Search Google Scholar
    • Export Citation
  • 12. Sobel RA, Hickey WF, Seilhean D. Primary diseases of the white matter. In: Gray F, De Girolami U, Poirier J. Escourol and Poirier manual of basic neuropathology. 4th ed. Oxford, England: Butterworth-Heinemann, 2004; 157167.

    • Search Google Scholar
    • Export Citation
  • 13. Reindl M, Di Pauli F, Rostásy K, et al. The spectrum of MOG autoantibody-associated demyelinating diseases. Nat Rev Neurol 2013; 9: 455461.

    • Search Google Scholar
    • Export Citation

Advertisement

Pathology in Practice

Jennifer A. Eberly DVM1,2, Devon W. Hague DVM3, Kuldeep Singh DVM, PhD4,5, and Stéphane Lezmi DVM, PhD6,7
View More View Less
  • 1 Departments of Veterinary Clinical Medicine and Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802.
  • | 2 Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802.
  • | 3 Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802.
  • | 4 Departments of Veterinary Clinical Medicine and Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802.
  • | 5 Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802.
  • | 6 Departments of Veterinary Clinical Medicine and Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802.
  • | 7 Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802.
History

A 4-year-old 1.18-kg (2.6-lb) spayed female Yorkshire Terrier was referred to the University of Illinois Veterinary Teaching Hospital for neurologic evaluation. The dog had been losing vision and circling to the right for 6 months. The dog became ataxic and unable to right itself after falling 1 week prior to referral.

Clinical and Gross Findings

On neurologic examination, the dog had a left head turn and tilt, thoracolumbar kyphosis, and extensor rigidity of the pelvic limbs. The dog was nonambulatory and tetraparetic and would twist and roll (ie, alligator roll) to the left when attempting to stand. Placing responses

History

A 4-year-old 1.18-kg (2.6-lb) spayed female Yorkshire Terrier was referred to the University of Illinois Veterinary Teaching Hospital for neurologic evaluation. The dog had been losing vision and circling to the right for 6 months. The dog became ataxic and unable to right itself after falling 1 week prior to referral.

Clinical and Gross Findings

On neurologic examination, the dog had a left head turn and tilt, thoracolumbar kyphosis, and extensor rigidity of the pelvic limbs. The dog was nonambulatory and tetraparetic and would twist and roll (ie, alligator roll) to the left when attempting to stand. Placing responses

Contributor Notes

Address correspondence to Dr. Hague (hague@illinois.edu).