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Meta-analysis of the effects of sometribove zinc suspension on the production and health of lactating dairy cows

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  • 1 Department of Animal Science, College of Food Agricultural and Environmental Sciences, The Ohio State University, Columbus, OH 43210.
  • | 2 Department of Statistics, College of Arts and Sciences, Kansas State University, Manhattan, KS 66506.
  • | 3 Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853.
  • | 4 School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721.
  • | 5 Department of Animal Science, College of Food Agricultural and Environmental Sciences, The Ohio State University, Columbus, OH 43210.
  • | 6 Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.
  • | 7 Department of Animal Science, College of Food Agricultural and Environmental Sciences, The Ohio State University, Columbus, OH 43210.
  • | 8 Department of Animal Sciences, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL 32611.

Abstract

Objective—To provide an updated evaluation of the efficacy and safety of sometribove zinc suspension (rbST-Zn), a form of recombinant bovine somatotropin, in lactating dairy cows.

Design—Meta-analysis.

Sample—26 studies published in peer-reviewed journals or reviewed by a regulatory agency.

Procedures—To be included, a study had to involve the use of the rbST-Zn formulation available to US producers in accordance with the label instructions for treatment initiation (57 to 70 days postpartum), dose (500 mg, q 14 d), and route (SC).

Results—For cows treated with rbST-Zn, mean milk, 3.5% fat-corrected milk, fat, and protein yields were increased by 4.00, 4.04, 0.144, and 0.137 kg/d (8.8, 8.89, 0.32, and 0.30 lb/d), respectively; however, the concentration of milk components did not change. Pregnancy proportion for the first 2 breeding cycles was increased by 5.4%, and pregnancy proportion for the duration of the trial was reduced by 5.5% for rbST-Zn–treated cows, compared with proportions for untreated cows. Mean body condition score (1 to 5 scale) was reduced by 0.06 points during the period of rbST-Zn use for treated cows. Administration of rbST-Zn had no effect on milk somatic cell count, the number of days to pregnancy, or inseminations per pregnancy; rates of fetal loss, twins, cystic ovaries, clinical lameness, lameness lesions, or traumatic lesions of the integumentary system; and odds of clinical mastitis or culling.

Conclusions and Clinical Relevance—Results indicated that rbST-Zn administration to dairy cows effectively increases milk production with no adverse effects on cow health and well-being.

Abstract

Objective—To provide an updated evaluation of the efficacy and safety of sometribove zinc suspension (rbST-Zn), a form of recombinant bovine somatotropin, in lactating dairy cows.

Design—Meta-analysis.

Sample—26 studies published in peer-reviewed journals or reviewed by a regulatory agency.

Procedures—To be included, a study had to involve the use of the rbST-Zn formulation available to US producers in accordance with the label instructions for treatment initiation (57 to 70 days postpartum), dose (500 mg, q 14 d), and route (SC).

Results—For cows treated with rbST-Zn, mean milk, 3.5% fat-corrected milk, fat, and protein yields were increased by 4.00, 4.04, 0.144, and 0.137 kg/d (8.8, 8.89, 0.32, and 0.30 lb/d), respectively; however, the concentration of milk components did not change. Pregnancy proportion for the first 2 breeding cycles was increased by 5.4%, and pregnancy proportion for the duration of the trial was reduced by 5.5% for rbST-Zn–treated cows, compared with proportions for untreated cows. Mean body condition score (1 to 5 scale) was reduced by 0.06 points during the period of rbST-Zn use for treated cows. Administration of rbST-Zn had no effect on milk somatic cell count, the number of days to pregnancy, or inseminations per pregnancy; rates of fetal loss, twins, cystic ovaries, clinical lameness, lameness lesions, or traumatic lesions of the integumentary system; and odds of clinical mastitis or culling.

Conclusions and Clinical Relevance—Results indicated that rbST-Zn administration to dairy cows effectively increases milk production with no adverse effects on cow health and well-being.

Contributor Notes

Milliken and Associates, LLC (Milliken) received funding from Elanco, a division of Eli Lilly and Co, for statistical consultation. The other authors have no conflicts of interest to declare regarding the performance of this study or the information contained in this manuscript.

Address correspondence to Dr. St-Pierre (st-pierre.8@osu.edu).