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Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

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  • 1 Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
  • | 2 Departments of Surgical and Radiological Sciences.
  • | 3 Departments of Pathology, Microbiology, and Immunology.
  • | 4 Departments of Surgical and Radiological Sciences.
  • | 5 School of Veterinary Medicine, University of California-Davis, Davis, CA 95616; and the Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706.
  • | 6 Departments of Surgical and Radiological Sciences.

Abstract

Objective—To determine prevalence, reason for evaluation, treatment, and outcome for dogs and cats with presumed solitary ocular lymphoma (PSOL).

Design—Retrospective case series.

Animals—7 dogs and 2 cats with PSOL.

Procedures—Medical records were reviewed. Progression-free survival time (PFST) and overall survival time (OST) were determined.

Results—Animals with intraocular (4 dogs and 1 cat) or conjunctival (3 dogs and 1 cat) lymphoma represented 0.1% and 0.08% of patients with lymphoma evaluated at the hospital during the study period, respectively. Animals with intraocular lymphoma represented 0.19% of all patients with uveitis; animals with conjunctival lymphoma represented 0.16% of all patients with conjunctivitis. Tumors included B-cell (2 intraocular and 1 conjunctival), non–B-cell, non–T-cell (1 intraocular), and T-cell (3 conjunctival) neoplasms; immunophenotype of 2 uveal lymphomas was not determined. Treatments included enucleation (4 intraocular) and chemotherapy (3 intraocular and 2 conjunctival). All dogs with intraocular lymphoma developed neurologic signs. Lymph node metastasis was detected in 2 patients with conjunctival lymphoma. Median PFST and OST were 178 days for all animals with PSOL, dogs with PSOL, and animals with intraocular lymphoma. Median PFST and OST for animals with conjunctival lymphoma were 221 and 549 days, respectively.

Conclusions and Clinical Relevance—Results indicated PSOL was uncommon, but should be considered a differential diagnosis for animals with uveitis or conjunctivitis. Performance of MRI and cytologic analysis of CSF and regional lymph node aspirate samples may be beneficial for such patients. Prognosis seemed to be better for animals with conjunctival lymphoma than it was for those with intraocular lymphoma.

Abstract

Objective—To determine prevalence, reason for evaluation, treatment, and outcome for dogs and cats with presumed solitary ocular lymphoma (PSOL).

Design—Retrospective case series.

Animals—7 dogs and 2 cats with PSOL.

Procedures—Medical records were reviewed. Progression-free survival time (PFST) and overall survival time (OST) were determined.

Results—Animals with intraocular (4 dogs and 1 cat) or conjunctival (3 dogs and 1 cat) lymphoma represented 0.1% and 0.08% of patients with lymphoma evaluated at the hospital during the study period, respectively. Animals with intraocular lymphoma represented 0.19% of all patients with uveitis; animals with conjunctival lymphoma represented 0.16% of all patients with conjunctivitis. Tumors included B-cell (2 intraocular and 1 conjunctival), non–B-cell, non–T-cell (1 intraocular), and T-cell (3 conjunctival) neoplasms; immunophenotype of 2 uveal lymphomas was not determined. Treatments included enucleation (4 intraocular) and chemotherapy (3 intraocular and 2 conjunctival). All dogs with intraocular lymphoma developed neurologic signs. Lymph node metastasis was detected in 2 patients with conjunctival lymphoma. Median PFST and OST were 178 days for all animals with PSOL, dogs with PSOL, and animals with intraocular lymphoma. Median PFST and OST for animals with conjunctival lymphoma were 221 and 549 days, respectively.

Conclusions and Clinical Relevance—Results indicated PSOL was uncommon, but should be considered a differential diagnosis for animals with uveitis or conjunctivitis. Performance of MRI and cytologic analysis of CSF and regional lymph node aspirate samples may be beneficial for such patients. Prognosis seemed to be better for animals with conjunctival lymphoma than it was for those with intraocular lymphoma.

Contributor Notes

Dr. Wiggans' present address is Veterinary Medical Teaching Hospital, University of California-Davis, Davis, CA 95616. Dr. Frazier's present address is Department of Small Animal Clinical Sciences, Veterinary Medical Center, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996.

All animals in this study were evaluated and treated at the University of California-Davis Veterinary Medical Teaching Hospital.

Supported in part by the RM Cello Endowment and the Toots Fund.

The authors thank John Doval for assistance with figure preparation.

Address correspondence to Dr. Maggs (djmaggs@ucdavis.edu).