1. American Animal Hospital Association website. Raw protein diet position statement. Available at: www.aahanet.org/Library/Raw_Food_Diet.aspx. Accessed Aug 11, 2013.
2. AVMA website. Raw or undercooked animal-source protein in cat and dog diets. Available at: www.avma.org/KB/Policies/Pages/Raw-or-Undercooked-Animal-Source-Protein-in-Cat-and-Dog-Diets.aspx. Accessed Aug 11, 2013.
3. Canadian Veterinary Medical Association website. CVMA policy on raw or undercooked animal-source protein in cat and dog diets. Available at: www.cvma.net/doc.asp?id=21753. Accessed Aug 11, 2013.
4 Pet Partners website. Raw protein diet policy. Available at: www.petpartners.org/rawdiet. Accessed Aug 11, 2013.
5. Schlesinger DP, Joffe DJ. Raw food diets in companion animals: a critical review. Can Vet J 2011; 52: 50–54.
6. Strohmeyer RA, Morley PS & Hyatt DR, et al. Evaluation of bacterial and protozoal contamination of commercially available raw meat diets for dogs. J Am Vet Med Assoc 2006; 228: 537–542.
7. Billinghurst I. Give your dog a bone: the practical commonsense way to feed dogs for a long healthy life. Alexandria, NSW, Australia: Bridge Printery Ian Billinghurst, 1993.
8. Schultze KR, ed. Natural nutrition for dogs and cats: the ultimate diet. Carlsbad, Calif: Hay House Inc, 1998.
9. Volhard W, Brown KL. The holistic guide for a healthy dog. New York: Howell Book House, 1995.
10. Pitout JD, Reisbig MD & Mulvey M, et al. Association between handling of pet treats and infection with Salmonella enterica serotype Newport expressing the AmpC beta-lactamase, CMY-2. J Clin Microbiol 2003; 41: 4578–4582.
11. Clark C, Cunningham J & Ahmed R, et al. Characterization of Salmonella associated with pig ear dog treats in Canada. J Clin Microbiol 2001; 39: 3962–3968.
12. White DG, Datta A & McDermott P, et al. Antimicrobial susceptibility and genetic relatedness of Salmonella serovars isolated from animal-derived dog treats in the USA. J Antimicrobial Chemother 2003; 52: 860–863.
13. Finley R, Reid-Smith R & Ribble C, et al. The occurrence and antimicrobial sensitivity of salmonellae isolated from commercially available pig ear pet treats. Zoonoses Public Health 2008; 55: 455–461.
14. Freeman LM, Janecko N, Weese JS. Nutritional and microbial analysis of bully sticks and survey of opinions about pet treats. Can Vet J 2013; 54: 50–54.
15. de-Oliveira LD, Carciofi AC & Oliveira MC, et al. Effects of six carbohydrate sources on diet digestibility and postprandial glucose and insulin response in cats. J Anim Sci 2008; 86: 2237–2246.
16. Hazewinkel H, Vandenbrom W & Vantklooster A, et al. Calcium metabolism in Great Dane dogs fed diets with various calcium and phosphorus levels. J Nutr 1991; 121:S99–S106.
17. Meyer H, Zentek J & Habernoll H, et al. Digestibility and compatibility of mixed diets and faecal consistency in different breeds of dog. Zentralbl Veterinarmed A 1999; 46: 155–165.
18. Axelsson E, Ratnakumar A & Arendt M-L, et al. The genomic signature of dog domestication reveals adaptation to a starch-rich diet. Nature 2013; 495;360–364.
19. Association of American Feed Control Officials. Official publication. Oxford, Ind: Association of American Feed Control Officials, 2012.
20. Nestle M, Nesheim M. Feed your pet right: the authoritative guide to feeding your dog and cat. New York: Free Press, 2010.
21. FDA website. Pet food recall products list. Available at: www.fda.gov/AnimalVeterinary/SafetyHealth/RecallsWithdrawals/default.htm. Accessed Aug 11, 2013.
22. FDA website. Recalls, market withdrawals, & safety alerts. Available at: www.fda.gov/safety/recalls/default.htm. Accessed Aug 11, 2013.
23. Steel RJS. Thiamine deficiency in a cat associated with the preservation of “pet meat” with sulphur dioxide. Aust Vet J 1997; 75: 719–721.
24. Boermans HJ, Leung MCK. Mycotoxins and the pet food industry: toxicological evidence and risk assessment. Int J Food Microbiol 2007; 119: 95–102.
25. Morita T, Awakura T & Shimada A, et al. Vitamin-D toxicosis in cats: natural outbreak and experimental study. J Vet Med Sci 1995; 57: 831–837.
26. Bernard MT. Raising cats naturally: how to care for your cat the way nature intended. Sandy, Utah: Aardvark Global Pub, 2004.
27. Dijcker JC, Hagen-Plantinga A & Everts H, et al. Dietary and animal-related factors associate with the rate of urinary oxalate and calcium excretion in dogs and cats. Vet Rec 2012; 171: 46.
28. Crissey SD, Swanson JA & Lintzenich BA, et al. Use of a raw meat-based diet or a dry kibble diet for sand cats (Felis margarita). J Anim Sci 1997; 75: 2154–2160.
29. Vester BM, Burke SL & Liu KJ, et al. Influence of feeding raw or extruded feline diets on nutrient digestibility and nitrogen metabolism of African wildcats (Felis lybica). Zoo Biol 2010; 29: 676–686.
30. Kerr KR, Vester Boler BM & Morris CL, et al. Apparent total tract energy and macronutrient digestibility and fecal fermentative end-product concentrations of domestic cats fed extruded, raw beef-based, and cooked beef-based diets. J Anim Sci 2012; 90: 515–522.
31. Hendriks WH, Emmens MM & Trass B, et al. Heat processing changes the protein quality of canned cat foods as measured by a rat bioassay. J Anim Sci 1999; 77: 669–676.
32. Williams PA, Hodgkinson SM & Rutherfurd SM, et al. Lysine content in canine diets can be severely heat damaged. J Nutr 2006; 136:1998S–2000S.
33. Rutherfurd SM, Rutherfurd-Markwick KJ, Moughan PJ. Available (ileal digestible reactive) lysine in selected pet foods. J Agric Food Chem 2007; 55: 3517–3522.
34. Meade SJ, Reid EA, Gerrard JA. The impact of processing on the nutritional quality of food proteins. JAOAC 2005; 88: 904–922.
35. Friedman M. Food browning and its prevention: an overview. J Agric Food Chem 1996; 44: 631–653.
36. Damodaran S. Amino acids, peptides and proteins. In: Fennema OR ed. Food chemistry. 3rd ed. New York: Marcel Dekker Inc, 1996;321–429.
37. National Research Council Ad Hoc Committee on Dogs and Cats. In: Nutrient requirements of dogs and cats. Washington, DC: National Academies Press, 2006.
38. Larsson SC, Wolk A. Meat consumption and risk of colorectal cancer: a meta-analysis of prospective studies. Intl J Cancer 2006; 119: 2657–2664.
39. Sugimura T, Wakabayashi K & Nakagama H, et al. Heterocyclic amines: mutagens/carcinogens produced during cooking of meat and fish. Cancer Sci 2004; 95: 290–299.
40. Knize MG, Salmon CP, Felton JS. Mutagenic activity and heterocyclic amine carcinogens in commercial pet foods. Mutat Res 2003; 539: 195–201.
41. Freeman LM, Michel KE. Evaluation of raw food diets (Erratum published in J Am Vet Med Assoc 2001; 218:1716). J Am Vet Med Assoc 2001; 218: 705–709.
42. Taylor MB, Geiger DA & Saker KE, et al. Diffuse osteopenia and myelopathy in a puppy fed a diet composed of an organic premix and raw ground beef. J Am Vet Med Assoc 2009; 234: 1041–1048.
43. Dillitzer N, Becker N, Kienzle E. Intake of minerals, trace elements and vitamins in bone and raw food rations in adults dogs. Br J Nutr 2011; 106:S53–S56.
44. Larsen JA, Parks EM & Heinze CR, et al. Evaluation of recipes for home-prepared diets for dogs and cats with chronic kidney disease. J Am Vet Med Assoc 2012; 240: 532–538.
45. Heinze CR, Gomez FC, Freeman LM. Assessment of commercial diets and recipes for home-prepared diets recommended for dogs with cancer. J Am Vet Med Assoc 2012; 241: 1453–1460.
46. Stockman J, Fascetti AJ & Kass PH, et al. Evaluation of recipes of home-prepared maintenance diets for dogs. J Am Vet Med Assoc 2013; 242: 1500–1505.
47. KuKanich KS. Update on Salmonella spp contamination of pet food, treats, and nutritional products and safe feeding recommendations. J Am Vet Med Assoc 2011; 238: 1430–1434.
48. LeJeune JT, Hancock DD. Public health concerns associated with feeding raw meat diets to dogs. J Am Vet Med Assoc 2001; 219: 1222–1225.
49. Joffe DJ, Schlesinger DP. Preliminary assessment of the risk of Salmonella infection in dogs fed raw chicken diets. Can Vet J 2002; 43: 441–442.
50. Weese JS, Rousseau J, Arroyo L. Bacteriological evaluation of commercial canine and feline raw diets. Can Vet J 2005; 46: 513–516.
51. Finley R, Reid-Smith R & Ribble C, et al. The occurrence and antimicrobial susceptibility of Salmonellae isolated from commercially available canine raw food diets in three Canadian cities. Zoonoses Public Health 2008; 55: 462–469.
52. Lenz J, Joffe D & Kauffman M, et al. Perceptions, practices, and consequences associated with foodborne pathogens and the feeding of raw meat to dogs. Can Vet J 2009; 50: 637–643.
53. Selmi M, Stefanelli S & Bilei S, et al. Contaminated commercial dehydrated food as source of multiple Salmonella serotypes outbreak in a municipal kennel in Tuscany. Vet Italiana 2011; 47: 183–190.
54. Behravesh CB, Ferraro A & Deasy M, et al. Human Salmonella infections linked to contaminated dry dog and cat food, 2006–2008. Pediatrics 2010; 126: 477–483.
55. Chengappa MM, Staats J & Oberst RD, et al. Prevalence of Salmonella in raw meat used in diets of racing Greyhounds. J Vet Diagn Invest 1993; 5: 372–377.
56. Stiver SL, Frazier KS & Mauel MJ, et al. Septicemic salmonellosis in two cats fed a raw-meat diet. J Am Anim Hosp Assoc 2003; 39: 538–542.
57. Leonard EK, Pearl DL & Finley RL, et al. Evaluation of pet-related management factors and the risk of Salmonella spp. carriage in pet dogs from volunteer households in Ontario (2005–2006). Zoonoses Public Health 2011; 58: 140–149.
58. Morley PS, Strohmeyer RA & Tankson JD, et al. Evaluation of the association between feeding raw meat and Salmonella enterica infections at a Greyhound breeding facility. J Am Vet Med Assoc 2006; 228: 1524–1532.
59. Cui S, Ge B & Zheng J, et al. Prevalence and antimicrobial resistance of Campylobacter spp and Salmonella serovars in organic chicken from Maryland retail stores. Appl Environ Microbiol 2005; 71: 4108–4111.
60. Bohaychuk VM, Gensler GE & King RK, et al. Occurrence of pathogens in raw and ready-to-eat meat and poultry products collected from the retail marketplace in Edmonton, Alberta, Canada. J Food Prot 2006; 69: 2176–2182.
61. M'ikanatha NM, Sandt CH & Localio AR, et al. Multidrug-resistant Salmonella isolates from retail chicken meat compared with human clinical isolates. Foodborne Pathog Dis 2010; 7: 929–934.
62. Lestari SI, Han F & Wang F, et al. Prevalence and antimicrobial resistance of Salmonella serovars in conventional and organic chicken from Louisiana retail stores. J Food Prot 2009; 72: 1165–1172.
63. Cook A, Odumeru J & Lee S, et al. Campylobacter, Salmonella, Listeria monocytogenes, verotoxigenic Escherichia coli, and Escherichia coli prevalence, enumeration, and subtypes on retail chicken breasts with and without skin. J Food Prot 2012; 75: 34–40.
64. Zhao T, Foyle MP & Fedorka-Cray PJ, et al. Occurrence of Salmonella enterica serotype Typhimurium DT104A in retail ground beef. J Food Prot 2002; 65: 403–407.
65. Mollenkopf DF, Kleinhenz KE & Funk JA, et al. Salmonella enterica and Escherichia coli harboring blaCMY in retail beef and pork products. Foodborne Pathog Dis 2011; 8: 333–336.
66. Smielewska-Los E, Rypula K, Pacon J. The influence of feeding and maintenance system on the occurrence of Toxoplasma gondii infections in dogs. Pol J Vet Sci 2002; 5: 231–234.
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68. Dubey JP, Hill DE & Jones JL, et al. Prevalence of viable Toxoplasma gondii in beef, chicken, and pork from retail meat stores in the United States: risk assessment to consumers. J Parasitol 2005; 91: 1082–1093.
69. Antolova D & Reiterova K Miterpakova M, et al. The first finding of Echinococcus multilocularis in dogs in Slovakia: an emerging risk for spreading of infection. Zoonoses Public Health 2009; 56: 53–58.
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71. Rumbeiha W, Morrison J. A review of class I and class II pet food recalls involving chemical contaminants from 1996 to 2008. J Med Toxicol 2011; 7: 60–66.
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The authors thank Drs. Dottie Laflamme, Nicholas Cave, and David Dzanis for technical assistance.
1. American Animal Hospital Association website. Raw protein diet position statement. Available at: www.aahanet.org/Library/Raw_Food_Diet.aspx. Accessed Aug 11, 2013.
2. AVMA website. Raw or undercooked animal-source protein in cat and dog diets. Available at: www.avma.org/KB/Policies/Pages/Raw-or-Undercooked-Animal-Source-Protein-in-Cat-and-Dog-Diets.aspx. Accessed Aug 11, 2013.
3. Canadian Veterinary Medical Association website. CVMA policy on raw or undercooked animal-source protein in cat and dog diets. Available at: www.cvma.net/doc.asp?id=21753. Accessed Aug 11, 2013.
4 Pet Partners website. Raw protein diet policy. Available at: www.petpartners.org/rawdiet. Accessed Aug 11, 2013.
5. Schlesinger DP, Joffe DJ. Raw food diets in companion animals: a critical review. Can Vet J 2011; 52: 50–54.
6. Strohmeyer RA, Morley PS & Hyatt DR, et al. Evaluation of bacterial and protozoal contamination of commercially available raw meat diets for dogs. J Am Vet Med Assoc 2006; 228: 537–542.
7. Billinghurst I. Give your dog a bone: the practical commonsense way to feed dogs for a long healthy life. Alexandria, NSW, Australia: Bridge Printery Ian Billinghurst, 1993.
8. Schultze KR, ed. Natural nutrition for dogs and cats: the ultimate diet. Carlsbad, Calif: Hay House Inc, 1998.
9. Volhard W, Brown KL. The holistic guide for a healthy dog. New York: Howell Book House, 1995.
10. Pitout JD, Reisbig MD & Mulvey M, et al. Association between handling of pet treats and infection with Salmonella enterica serotype Newport expressing the AmpC beta-lactamase, CMY-2. J Clin Microbiol 2003; 41: 4578–4582.
11. Clark C, Cunningham J & Ahmed R, et al. Characterization of Salmonella associated with pig ear dog treats in Canada. J Clin Microbiol 2001; 39: 3962–3968.
12. White DG, Datta A & McDermott P, et al. Antimicrobial susceptibility and genetic relatedness of Salmonella serovars isolated from animal-derived dog treats in the USA. J Antimicrobial Chemother 2003; 52: 860–863.
13. Finley R, Reid-Smith R & Ribble C, et al. The occurrence and antimicrobial sensitivity of salmonellae isolated from commercially available pig ear pet treats. Zoonoses Public Health 2008; 55: 455–461.
14. Freeman LM, Janecko N, Weese JS. Nutritional and microbial analysis of bully sticks and survey of opinions about pet treats. Can Vet J 2013; 54: 50–54.
15. de-Oliveira LD, Carciofi AC & Oliveira MC, et al. Effects of six carbohydrate sources on diet digestibility and postprandial glucose and insulin response in cats. J Anim Sci 2008; 86: 2237–2246.
16. Hazewinkel H, Vandenbrom W & Vantklooster A, et al. Calcium metabolism in Great Dane dogs fed diets with various calcium and phosphorus levels. J Nutr 1991; 121:S99–S106.
17. Meyer H, Zentek J & Habernoll H, et al. Digestibility and compatibility of mixed diets and faecal consistency in different breeds of dog. Zentralbl Veterinarmed A 1999; 46: 155–165.
18. Axelsson E, Ratnakumar A & Arendt M-L, et al. The genomic signature of dog domestication reveals adaptation to a starch-rich diet. Nature 2013; 495;360–364.
19. Association of American Feed Control Officials. Official publication. Oxford, Ind: Association of American Feed Control Officials, 2012.
20. Nestle M, Nesheim M. Feed your pet right: the authoritative guide to feeding your dog and cat. New York: Free Press, 2010.
21. FDA website. Pet food recall products list. Available at: www.fda.gov/AnimalVeterinary/SafetyHealth/RecallsWithdrawals/default.htm. Accessed Aug 11, 2013.
22. FDA website. Recalls, market withdrawals, & safety alerts. Available at: www.fda.gov/safety/recalls/default.htm. Accessed Aug 11, 2013.
23. Steel RJS. Thiamine deficiency in a cat associated with the preservation of “pet meat” with sulphur dioxide. Aust Vet J 1997; 75: 719–721.
24. Boermans HJ, Leung MCK. Mycotoxins and the pet food industry: toxicological evidence and risk assessment. Int J Food Microbiol 2007; 119: 95–102.
25. Morita T, Awakura T & Shimada A, et al. Vitamin-D toxicosis in cats: natural outbreak and experimental study. J Vet Med Sci 1995; 57: 831–837.
26. Bernard MT. Raising cats naturally: how to care for your cat the way nature intended. Sandy, Utah: Aardvark Global Pub, 2004.
27. Dijcker JC, Hagen-Plantinga A & Everts H, et al. Dietary and animal-related factors associate with the rate of urinary oxalate and calcium excretion in dogs and cats. Vet Rec 2012; 171: 46.
28. Crissey SD, Swanson JA & Lintzenich BA, et al. Use of a raw meat-based diet or a dry kibble diet for sand cats (Felis margarita). J Anim Sci 1997; 75: 2154–2160.
29. Vester BM, Burke SL & Liu KJ, et al. Influence of feeding raw or extruded feline diets on nutrient digestibility and nitrogen metabolism of African wildcats (Felis lybica). Zoo Biol 2010; 29: 676–686.
30. Kerr KR, Vester Boler BM & Morris CL, et al. Apparent total tract energy and macronutrient digestibility and fecal fermentative end-product concentrations of domestic cats fed extruded, raw beef-based, and cooked beef-based diets. J Anim Sci 2012; 90: 515–522.
31. Hendriks WH, Emmens MM & Trass B, et al. Heat processing changes the protein quality of canned cat foods as measured by a rat bioassay. J Anim Sci 1999; 77: 669–676.
32. Williams PA, Hodgkinson SM & Rutherfurd SM, et al. Lysine content in canine diets can be severely heat damaged. J Nutr 2006; 136:1998S–2000S.
33. Rutherfurd SM, Rutherfurd-Markwick KJ, Moughan PJ. Available (ileal digestible reactive) lysine in selected pet foods. J Agric Food Chem 2007; 55: 3517–3522.
34. Meade SJ, Reid EA, Gerrard JA. The impact of processing on the nutritional quality of food proteins. JAOAC 2005; 88: 904–922.
35. Friedman M. Food browning and its prevention: an overview. J Agric Food Chem 1996; 44: 631–653.
36. Damodaran S. Amino acids, peptides and proteins. In: Fennema OR ed. Food chemistry. 3rd ed. New York: Marcel Dekker Inc, 1996;321–429.
37. National Research Council Ad Hoc Committee on Dogs and Cats. In: Nutrient requirements of dogs and cats. Washington, DC: National Academies Press, 2006.
38. Larsson SC, Wolk A. Meat consumption and risk of colorectal cancer: a meta-analysis of prospective studies. Intl J Cancer 2006; 119: 2657–2664.
39. Sugimura T, Wakabayashi K & Nakagama H, et al. Heterocyclic amines: mutagens/carcinogens produced during cooking of meat and fish. Cancer Sci 2004; 95: 290–299.
40. Knize MG, Salmon CP, Felton JS. Mutagenic activity and heterocyclic amine carcinogens in commercial pet foods. Mutat Res 2003; 539: 195–201.
41. Freeman LM, Michel KE. Evaluation of raw food diets (Erratum published in J Am Vet Med Assoc 2001; 218:1716). J Am Vet Med Assoc 2001; 218: 705–709.
42. Taylor MB, Geiger DA & Saker KE, et al. Diffuse osteopenia and myelopathy in a puppy fed a diet composed of an organic premix and raw ground beef. J Am Vet Med Assoc 2009; 234: 1041–1048.
43. Dillitzer N, Becker N, Kienzle E. Intake of minerals, trace elements and vitamins in bone and raw food rations in adults dogs. Br J Nutr 2011; 106:S53–S56.
44. Larsen JA, Parks EM & Heinze CR, et al. Evaluation of recipes for home-prepared diets for dogs and cats with chronic kidney disease. J Am Vet Med Assoc 2012; 240: 532–538.
45. Heinze CR, Gomez FC, Freeman LM. Assessment of commercial diets and recipes for home-prepared diets recommended for dogs with cancer. J Am Vet Med Assoc 2012; 241: 1453–1460.
46. Stockman J, Fascetti AJ & Kass PH, et al. Evaluation of recipes of home-prepared maintenance diets for dogs. J Am Vet Med Assoc 2013; 242: 1500–1505.
47. KuKanich KS. Update on Salmonella spp contamination of pet food, treats, and nutritional products and safe feeding recommendations. J Am Vet Med Assoc 2011; 238: 1430–1434.
48. LeJeune JT, Hancock DD. Public health concerns associated with feeding raw meat diets to dogs. J Am Vet Med Assoc 2001; 219: 1222–1225.
49. Joffe DJ, Schlesinger DP. Preliminary assessment of the risk of Salmonella infection in dogs fed raw chicken diets. Can Vet J 2002; 43: 441–442.
50. Weese JS, Rousseau J, Arroyo L. Bacteriological evaluation of commercial canine and feline raw diets. Can Vet J 2005; 46: 513–516.
51. Finley R, Reid-Smith R & Ribble C, et al. The occurrence and antimicrobial susceptibility of Salmonellae isolated from commercially available canine raw food diets in three Canadian cities. Zoonoses Public Health 2008; 55: 462–469.
52. Lenz J, Joffe D & Kauffman M, et al. Perceptions, practices, and consequences associated with foodborne pathogens and the feeding of raw meat to dogs. Can Vet J 2009; 50: 637–643.
53. Selmi M, Stefanelli S & Bilei S, et al. Contaminated commercial dehydrated food as source of multiple Salmonella serotypes outbreak in a municipal kennel in Tuscany. Vet Italiana 2011; 47: 183–190.
54. Behravesh CB, Ferraro A & Deasy M, et al. Human Salmonella infections linked to contaminated dry dog and cat food, 2006–2008. Pediatrics 2010; 126: 477–483.
55. Chengappa MM, Staats J & Oberst RD, et al. Prevalence of Salmonella in raw meat used in diets of racing Greyhounds. J Vet Diagn Invest 1993; 5: 372–377.
56. Stiver SL, Frazier KS & Mauel MJ, et al. Septicemic salmonellosis in two cats fed a raw-meat diet. J Am Anim Hosp Assoc 2003; 39: 538–542.
57. Leonard EK, Pearl DL & Finley RL, et al. Evaluation of pet-related management factors and the risk of Salmonella spp. carriage in pet dogs from volunteer households in Ontario (2005–2006). Zoonoses Public Health 2011; 58: 140–149.
58. Morley PS, Strohmeyer RA & Tankson JD, et al. Evaluation of the association between feeding raw meat and Salmonella enterica infections at a Greyhound breeding facility. J Am Vet Med Assoc 2006; 228: 1524–1532.
59. Cui S, Ge B & Zheng J, et al. Prevalence and antimicrobial resistance of Campylobacter spp and Salmonella serovars in organic chicken from Maryland retail stores. Appl Environ Microbiol 2005; 71: 4108–4111.
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