Comparison of a chlorambucil-prednisolone combination with an azathioprine-prednisolone combination for treatment of chronic enteropathy with concurrent protein-losing enteropathy in dogs: 27 cases (2007–2010)

Julien R. S. Dandrieux School of Veterinary Science, University of Liverpool, Neston CH64 7TE, England.

Search for other papers by Julien R. S. Dandrieux in
Current site
Google Scholar
PubMed
Close
 Dr med vet, DACVIM
,
Peter-John M. Noble School of Veterinary Science, University of Liverpool, Neston CH64 7TE, England.

Search for other papers by Peter-John M. Noble in
Current site
Google Scholar
PubMed
Close
 BVM&S, PhD
,
Timothy J. Scase Bridge Pathology Ltd, PO Box 2877, Bristol, BS8 9FH, England.

Search for other papers by Timothy J. Scase in
Current site
Google Scholar
PubMed
Close
 BVM&S, PhD, DACVP
,
Peter J. Cripps School of Veterinary Science, University of Liverpool, Neston CH64 7TE, England.

Search for other papers by Peter J. Cripps in
Current site
Google Scholar
PubMed
Close
 BVSC, PhD
, and
Alexander J. German School of Veterinary Science, University of Liverpool, Neston CH64 7TE, England.

Search for other papers by Alexander J. German in
Current site
Google Scholar
PubMed
Close
 BVSC, PhD

Abstract

Objective—To compare treatment protocols for chronic enteropathy and concurrent protein-losing enteropathy that used prednisolone in conjunction with either azathioprine or chlorambucil in dogs.

Design—Retrospective case series.

Animals—27 dogs.

Procedures—All dogs had hypoalbuminemia (serum albumin concentration, < 18.0 g/L) and chronic enteropathy as diagnosed via complete gastrointestinal tract investigations including intestinal biopsy. Dogs received either an azathioprine-prednisolone combination (group A; n = 13) or a chlorambucil-prednisolone combination (group C; 14). Response to treatment was assessed by evaluation of body weight gain, serum albumin concentration, and duration of primary treatment.

Results—No significant pretreatment differences were detected between groups for any baseline variable (signalment and weight), clinicopathologic variable (albumin, cobalamin, and folate concentrations), or histopathologic findings. After treatment, serum albumin concentration and weight gain were significantly greater in group C. Median survival time for group A dogs was 30 days (95% confidence interval, 15 to 45 days) and was not reached for group C dogs. Duration of primary treatment was positively associated with the histopathologic presence of mild lacteal dilatation and use of a chlorambucil-prednisolone combination.

Conclusions and Clinical Relevance—Results suggested that a chlorambucil-prednisolone protocol is more efficacious for treatment of chronic enteropathy and concurrent protein-losing enteropathy, compared with an azathioprine-prednisolone combination. Given these findings, a prospective randomized clinical trial is warranted.

Abstract

Objective—To compare treatment protocols for chronic enteropathy and concurrent protein-losing enteropathy that used prednisolone in conjunction with either azathioprine or chlorambucil in dogs.

Design—Retrospective case series.

Animals—27 dogs.

Procedures—All dogs had hypoalbuminemia (serum albumin concentration, < 18.0 g/L) and chronic enteropathy as diagnosed via complete gastrointestinal tract investigations including intestinal biopsy. Dogs received either an azathioprine-prednisolone combination (group A; n = 13) or a chlorambucil-prednisolone combination (group C; 14). Response to treatment was assessed by evaluation of body weight gain, serum albumin concentration, and duration of primary treatment.

Results—No significant pretreatment differences were detected between groups for any baseline variable (signalment and weight), clinicopathologic variable (albumin, cobalamin, and folate concentrations), or histopathologic findings. After treatment, serum albumin concentration and weight gain were significantly greater in group C. Median survival time for group A dogs was 30 days (95% confidence interval, 15 to 45 days) and was not reached for group C dogs. Duration of primary treatment was positively associated with the histopathologic presence of mild lacteal dilatation and use of a chlorambucil-prednisolone combination.

Conclusions and Clinical Relevance—Results suggested that a chlorambucil-prednisolone protocol is more efficacious for treatment of chronic enteropathy and concurrent protein-losing enteropathy, compared with an azathioprine-prednisolone combination. Given these findings, a prospective randomized clinical trial is warranted.

All Time Past Year Past 30 Days
Abstract Views 1660 0 0
Full Text Views 4989 2654 164
PDF Downloads 4392 1891 179
Advertisement