Effects of treatment on respiratory rate, serum natriuretic peptide concentration, and Doppler echocardiographic indices of left ventricular filling pressure in dogs with congestive heart failure secondary to degenerative mitral valve disease and dilated cardiomyopathy
Search for other papers by Karsten E. Schober in
Current site
Google Scholar
PubMed
Search for other papers by Taye M. Hart in
Current site
Google Scholar
PubMed
Search for other papers by Joshua A. Stern in
Current site
Google Scholar
PubMed
Search for other papers by Xiaobai Li in
Current site
Google Scholar
PubMed
Search for other papers by Valerie F. Samii in
Current site
Google Scholar
PubMed
Search for other papers by Lisa J. Zekas in
Current site
Google Scholar
PubMed
Search for other papers by Brian A. Scansen in
Current site
Google Scholar
PubMed
Search for other papers by John D. Bonagura in
Current site
Google Scholar
PubMed
Abstract
Objective—To evaluate the effects of treatment on respiratory rate, serum natriuretic peptide concentrations, and Doppler echocardiographic indices of left ventricular filling pressure in dogs with congestive heart failure (CHF) secondary to degenerative mitral valve disease (MVD) and dilated cardiomyopathy (DCM).
Design—Prospective cohort study.
Animals—63 client-owned dogs.
Procedures—Physical examination, thoracic radiography, analysis of natriuretic peptide concentrations, and Doppler echocardiography were performed twice, at baseline (examination 1) and 5 to 14 days later (examination 2). Home monitoring of respiratory rate was performed by the owners between examinations.
Results—In dogs with MVD, resolution of CHF was associated with a decrease in respiratory rate, serum N-terminal probrain natriuretic peptide (NT-proBNP) concentration, and diastolic functional class and an increase of the ratio of peak velocity of early diastolic transmitral flow to peak velocity of early diastolic lateral mitral annulus motion (E:Ea Lat). In dogs with DCM, resolution of CHF was associated with a decrease in respiratory rate and serum NT-proBNP concentration and significant changes in 7 Doppler echocardiographic variables, including a decrease of E:Ea Lat and the ratio of peak velocity of early diastolic transmitral flow to isovolumic relaxation time. Only respiratory rate predicted the presence of CHF at examination 2 with high accuracy.
Conclusions and Clinical Relevance—Resolution of CHF was associated with predictable changes in respiratory rate, serum NT-proBNP concentration, and selected Doppler echocardiographic variables in dogs with DCM and MVD. Home monitoring of respiratory rate was simple and was the most useful in the assessment of successful treatment of CHF.
| All Time | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 356 | 0 | 0 |
| Full Text Views | 2333 | 1073 | 104 |
| PDF Downloads | 756 | 246 | 16 |
