• 1.

    Klein WR, van der Velden MA, Ensink JM. Single intraoperative administration of antibiotic to cows with caecal torsion: wound infection and postoperative performance. A retrospective and prospective study. Vet Q 1994; 16 (suppl 2): S111S113.

    • Search Google Scholar
    • Export Citation
  • 2.

    Klein WR, Firth EC, Kievits JM, et al. Intra-abdominal versus intramuscular application of two ampicillin preparations in cows. J Vet Pharmacol Ther 1989; 12: 141146.

    • Search Google Scholar
    • Export Citation
  • 3.

    Chicoine AL, Boison JO, Parker S, et al. Kinetics and residues after intraperitoneal procaine penicillin G administration in lactating dairy cows. J Vet Pharmacol Ther 2009; 32: 289295.

    • Search Google Scholar
    • Export Citation
  • 4.

    Nouws JF, van Ginneken CA, Hekman P, et al. Comparative plasma ampicillin levels and bioavailability of five parenteral ampicillin formulations in ruminant calves. Vet Q 1982; 4: 6271.

    • Search Google Scholar
    • Export Citation
  • 5.

    Prescott JFGiguere S, ed. Antimicrobial therapy in veterinary medicine. 4th ed. Ames, Iowa: Blackwell Publishing, 2007; 121.

  • 6.

    Papich MG, Korsrud GO, Boison J, et al. A study of the disposition of procaine penicillin G in feedlot steers following intramuscular and subcutaneous injection. J Vet Pharmacol Ther 1993; 16: 317327.

    • Search Google Scholar
    • Export Citation

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What Is the Evidence?

Annette M. O'Connor BVSc, DVSc1, Stacie A. Gould2, Johann F. Coetzee BVSc, PhD, DACVCP3, Amanda J. Kreuder DVM4, and Paul J. Plummer DVM, PhD, DACVIM5
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  • 1 Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.
  • | 2 Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.
  • | 3 Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506.
  • | 4 Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.
  • | 5 Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011.
Problem

During a large animal clinical rotation at the College of Veterinary Medicine, Iowa State University, veterinary students commented on observing variability in the route by which perioperative antimicrobials were being administered to prevent surgical site infections in cattle. The clinicians indicated that preoperative parenteral administration of antimicrobials was likely the preferred route, as suggested by the literature available on antimicrobial use in other veterinary species; however, such use results in drug residues that prevent immediate slaughter of the affected cattle for use in the food supply when surgical findings suggest a poor prognosis. Consequently, veterinarians are often under pressure

Problem

During a large animal clinical rotation at the College of Veterinary Medicine, Iowa State University, veterinary students commented on observing variability in the route by which perioperative antimicrobials were being administered to prevent surgical site infections in cattle. The clinicians indicated that preoperative parenteral administration of antimicrobials was likely the preferred route, as suggested by the literature available on antimicrobial use in other veterinary species; however, such use results in drug residues that prevent immediate slaughter of the affected cattle for use in the food supply when surgical findings suggest a poor prognosis. Consequently, veterinarians are often under pressure

Contributor Notes

Address correspondence to Dr. O'Connor (oconnor@iastate.edu).