• 1.

    Brenner S, Bialy-Golan A, Ruocco V. Drug-induced pemphigus. Clin Dermatol 1998;16:393397.

  • 2.

    Paradisi A, Sampoqna F, DiPietro C, et al. Quality of life assessment in patients with pemphigus using a minimum set of evaluation tools. J Am Acad Dermatol 2009;60:261269.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Suter MM, Bruin A, Wyder M, et al. Autoimmune diseases of domestic animals: an update. In: Kwochka KW, Willemse T, Tscharner C, eds. Advances in veterinary dermatology. 3rd ed. Woburn, Mass: Butterworth-Heinemann, 1998;321328.

    • Search Google Scholar
    • Export Citation
  • 4.

    White SD. Diseases of the skin. In: Smith BP, ed. Large animal internal medicine. 3rd ed. St Louis: Mosby Co, 2002;1200.

  • 5.

    El Fekih N, Kharfi M, Karaa A, et al. Complete recovery from juvenile pemphigus vulgaris. Indian J Dermatol Venereol Leprol 2008;74:654655.

  • 6.

    Kanwar AJ, Kaur S. Pemphigus in children. Int J Dermatol 1991;30:343346.

  • 7.

    Graff-Lonnevig V, Kaaman T. Acta Paediatr Scand 1991;80:262265.

  • 8.

    Rees CA. Disorders of the skin. In: Reed SM, Bayly WM, Sellon DC, eds. Equine internal medicine. 2nd ed. St Louis: Saunders Co, 1998;687689.

    • Search Google Scholar
    • Export Citation
  • 9.

    Meuller RS, Krebs I, Power HT, et al. Pemphigus foliaceus in 91 dogs. J Am Anim Hosp Assoc 2006;42:189196.

  • 10.

    Olivry T, Bergwall KE, Atlee BA. Prolonged remission after immunosuppressive therapy in six dogs with pemphigus foliaceus. Vet Dermatol 2004;15:245252.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11.

    Vandenabeele SI, White SD, Affolter VK, et al. Pemphigus foliaceus in the horse: a retrospective study of 20 cases. Vet Dermatol 2004;15:381388.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12.

    Preziosi DE, Goldschmidt MH, Greek JS, et al. Feline pemphigus foliaceus: a retrospective analysis of 57 cases. Vet Dermatol 2003;14:313321.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13.

    Scott DW, Smith MC, Smith CA, et al. Pemphigus foliaceus in a goat. Agri-Practice 1984;5:3845.

  • 14.

    Jackson PG, Lloyd S, Jefferies AR. Pemphigus foliaceus in a goat. Vet Rec 1984;114:479.

  • 15.

    Valdez RA, Gelberg HB, Morin DE, et al. Use of corticosteroids and aurothioglucose in a pygmy goat with pemphigus foliaceus. J Am Vet Med Assoc 1995;207:761765.

    • Search Google Scholar
    • Export Citation
  • 16.

    Pappalardo E, Abramo F, Noli C. Pemphigus foliaceus in a goat. Vet Dermatol 2002;13:331336.

  • 17.

    Martin LK, Werth V, Villanueva E, et al. Interventions for pemphigus vulgaris and pemphigus foliaceus. Cochrane Database Syst Rev 2009;3:CD006263.

    • Search Google Scholar
    • Export Citation
  • 18.

    Empinotti JC, Diaz LA, Martins CR, et al. Endemic pemphigus foliaceus in western Parana, Brazil (1976–1988). Br J Dermatol 1990;123:431437.

    • Search Google Scholar
    • Export Citation
  • 19.

    Noli C, Koeman JP, Willemse T. A retrospective evaluation of adverse reactions to trimethoprim-sulphonamide combinations in dogs and cats. Vet Q 1995;17:123128.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 20.

    White SD, Carlotti DN, Pin D, et al. Putative drug-related pemphigus foliaceus in four dogs. Vet Dermatol 2002;13:195202.

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Successful treatment of juvenile pemphigus foliaceus in a Nigerian Dwarf goat

Jennifer Cornish DVM, DACVIM1 and Margaret Highland DVM2
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  • 1 Departments of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616
  • | 2 Departments of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616

Abstract

Case Description—A 2-month-old female Nigerian Dwarf goat was evaluated for a generalized crusting dermatitis; signs of depression; and fever of 1 month's duration.

Clinical Findings—Histologic evaluation of skin biopsy specimens revealed subcorneal pustules and rafts of acantholytic cells. No etiologic agents were detected in the biopsy material, and bacterial culture of skin biopsy specimens yielded no growth of pathological organisms. A diagnosis of pemphigus foliaceus was made.

Treatment and Outcome—Remission was achieved with a combination of SC administration of dexamethasone and IM administration of gold sodium thiomalate. The goat remained free of clinical signs for at least 26 months after discontinuation of all medications. No clinically apparent adverse effects of treatment were evident.

Clinical Relevance—This report represents the first description of successful treatment of juvenile pemphigus foliaceus in a goat by use of a novel protocol involving dexamethasone and gold sodium thiomalate.

Abstract

Case Description—A 2-month-old female Nigerian Dwarf goat was evaluated for a generalized crusting dermatitis; signs of depression; and fever of 1 month's duration.

Clinical Findings—Histologic evaluation of skin biopsy specimens revealed subcorneal pustules and rafts of acantholytic cells. No etiologic agents were detected in the biopsy material, and bacterial culture of skin biopsy specimens yielded no growth of pathological organisms. A diagnosis of pemphigus foliaceus was made.

Treatment and Outcome—Remission was achieved with a combination of SC administration of dexamethasone and IM administration of gold sodium thiomalate. The goat remained free of clinical signs for at least 26 months after discontinuation of all medications. No clinically apparent adverse effects of treatment were evident.

Clinical Relevance—This report represents the first description of successful treatment of juvenile pemphigus foliaceus in a goat by use of a novel protocol involving dexamethasone and gold sodium thiomalate.

Contributor Notes

Dr. Highland's present address is Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706.

Dr. Cornish's present address is Elgin Veterinary Hospital, 600 Hwy 290 E, Elgin, TX 78621.

Address correspondence to Dr. Cornish (jgamehen@gmail.com).