Effectiveness and safety of cefovecin sodium, an extended-spectrum injectable cephalosporin, in the treatment of cats with abscesses and infected wounds

Robert Six Pfizer Animal Health, 7000 Portage Rd, Kalamazoo, MI 49001.

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Dawn M. Cleaver Pfizer Animal Health, 7000 Portage Rd, Kalamazoo, MI 49001.

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Cindy J. Lindeman Pfizer Animal Health, 7000 Portage Rd, Kalamazoo, MI 49001.

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Judith Cherni Pfizer Animal Health, 7000 Portage Rd, Kalamazoo, MI 49001.

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Robert Chesebrough Pfizer Animal Health, 7000 Portage Rd, Kalamazoo, MI 49001.

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Georg Papp Pfizer Animal Health, 7000 Portage Rd, Kalamazoo, MI 49001.

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Terry L. Skogerboe Pfizer Animal Health, 7000 Portage Rd, Kalamazoo, MI 49001.

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Dan J. Weigel Pfizer Animal Health, 7000 Portage Rd, Kalamazoo, MI 49001.

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Joseph F. Boucher Pfizer Animal Health, 7000 Portage Rd, Kalamazoo, MI 49001.

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Michael R. Stegemann Pfizer Animal Health, 7000 Portage Rd, Kalamazoo, MI 49001.

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Abstract

Objective—To evaluate the effectiveness and safety of cefovecin sodium in the treatment of cats with naturally occurring skin infections (abscesses and infected wounds).

Design—Multicenter (26 sites), randomized, double-blind, controlled clinical trial.

Animals—Client-owned cats of any breed with naturally occurring skin infections with associated clinical signs and confirmatory bacteriologic culture results.

Procedures—Cats with clinical signs of skin and soft tissue infection were randomly allocated to receive a single dose of cefovecin (8 mg/kg [3.6 mg/lb], SC) followed by placebo drops administered orally once daily for 14 days or 1 SC placebo injection followed by cefadroxil (22 mg/kg [10 mg/lb], PO, once daily for 14 days). Only one 14-day treatment course was permitted.

Results—Effectiveness of cefovecin in the treatment of cats with abscesses and infected wounds was similar to that of cefadroxil. At the final assessment on day 28, 97% (86/89) of cefovecin-treated cats and 91% (80/88) of cefadroxil-treated cats were considered treatment successes. There were no serious adverse events or deaths related to treatment.

Conclusions and Clinical Relevance—1 SC injection of 8 mg of cefovecin/kg for the treatment of cats with naturally occurring skin infections (wounds and abscesses) was safe and as effective as cefadroxil administered orally at 22 mg/kg, once daily for 14 days.

Abstract

Objective—To evaluate the effectiveness and safety of cefovecin sodium in the treatment of cats with naturally occurring skin infections (abscesses and infected wounds).

Design—Multicenter (26 sites), randomized, double-blind, controlled clinical trial.

Animals—Client-owned cats of any breed with naturally occurring skin infections with associated clinical signs and confirmatory bacteriologic culture results.

Procedures—Cats with clinical signs of skin and soft tissue infection were randomly allocated to receive a single dose of cefovecin (8 mg/kg [3.6 mg/lb], SC) followed by placebo drops administered orally once daily for 14 days or 1 SC placebo injection followed by cefadroxil (22 mg/kg [10 mg/lb], PO, once daily for 14 days). Only one 14-day treatment course was permitted.

Results—Effectiveness of cefovecin in the treatment of cats with abscesses and infected wounds was similar to that of cefadroxil. At the final assessment on day 28, 97% (86/89) of cefovecin-treated cats and 91% (80/88) of cefadroxil-treated cats were considered treatment successes. There were no serious adverse events or deaths related to treatment.

Conclusions and Clinical Relevance—1 SC injection of 8 mg of cefovecin/kg for the treatment of cats with naturally occurring skin infections (wounds and abscesses) was safe and as effective as cefadroxil administered orally at 22 mg/kg, once daily for 14 days.

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