• 1.

    Boudrieau RJ. Fractures of the mandible. In: Johnson AL, Houlton JEF, Vannini R, eds. AO principles of fracture management in the dog and cat. Stuttgart, Germany: Georg Thieme Verlag, 2005;98115.

    • Search Google Scholar
    • Export Citation
  • 2.

    Toriumi DM, O'Grady K, Horlbeck DM. Mandibular reconstruction using bone morphogenetic protein 2: long-term follow-up in a canine model. Laryngoscope 1999;109:14811489.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Zakhary K, Motakis D, Hamdy RH. Effect of recombinant human bone morphogenetic protein 7 on bone density during distraction osteogenesis of the rabbit mandible. J Otolaryngol 2005;34:407414.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Arosarena OA, Falk A, Malmgren L. Defect repair in the rat mandible with bone morphogenic proteins and marrow cells. Arch Facial Plast Surg 2003;5:103108.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    Terheyden H, Wang H, Warnke PH. Acceleration of callus maturation using rhOP-1 in mandibular distraction osteogenesis in a rat model. Int J Oral Maxillofac Surg 2003;32:528533.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6.

    Boyne PJ. Animal studies of application of rhBMP-2 in maxillofacial reconstruction. Bone 1996;19(suppl 1):83S–92S.

  • 7.

    Boyne PJ. Application of bone morphogenetic proteins in the treatment of clinical oral and maxillofacial osseous defects. J Bone Joint Surg Am 2001;83-A(suppl 1):S146–S150.

    • Search Google Scholar
    • Export Citation
  • 8.

    Gautschi OP, Frey SP, Zellweger R. Bone morphogenetic proteins in clinical applications. ANZ J Surg 2007;77:626631.

  • 9.

    Abu-Serriah M, Kontaxis A, Ayoub A. Mechanical evaluation of mandibular defects reconstructed using osteogenic protein-1 (rhOP-1) in a sheep model: a critical analysis. Int J Oral Maxillofac Surg 2005;34:287293.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 10.

    Terheyden H, Jepsen S, Rueger DR. Mandibular reconstruction in miniature pigs with prefabricated vascularized bone grafts using recombinant human osteogenic protein-1: a preliminary study. Int J Oral Maxillofac Surg 1999;28:461463.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11.

    Terheyden H, Knak C, Jepsen S. Mandibular reconstruction with a prefabricated vascularized bone graft using recombinant human osteogenic protein-1: an experimental study in miniature pigs. Part I: prefabrication. Int J Oral Maxillofac Surg 2001;30:373379.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12.

    Terheyden H, Warnke P, Dunsche A. Mandibular reconstruction with prefabricated vascularized bone grafts using recombinant human osteogenic protein-1: an experimental study in miniature pigs. Part II: transplantation. Int J Oral Maxillofac Surg 2001;30:469478.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13.

    Moghadam HG, Urist MR, Sandor GK. Successful mandibular reconstruction using a BMP bioimplant. J Craniofac Surg 2001;12:119128.

  • 14.

    Kirker-Head CA, Boudrieau RJ, Kraus KH. Use of bone morphogenetic proteins for augmentation of bone regeneration. J Am Vet Med Assoc 2007;231:10391055.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 15.

    Boudrieau RJ, Mitchell SL, Seeherman H. Mandibular reconstruction of a partial hemimandibulectomy in a dog with severe malocclusion. Vet Surg 2004;33:119130.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16.

    Spector DI, Keating JH, Boudrieau RJ. Immediate mandibular reconstruction of a 5 cm defect using rhBMP-2 after partial mandibulectomy in a dog. Vet Surg 2007;36:752759.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 17.

    Pavletic MM, Trout NJ. Bullet, bite, and burn wounds in dogs and cats. Vet Clin North Am Small Anim Pract 2006;36:873893.

  • 18.

    Thompson LJ. Lead. In: Gupta RC, ed. Veterinary toxicology: basic and clinical principles. New York: Elsevier, 2007;438444.

  • 19.

    Umphlet RC, Johnson AL, Eurell JC. The effect of partial rostral hemimandibulectomy on mandibular mobility and temporomandibular joint morphology in the dog. Vet Surg 1988;17:186193.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 20.

    Nunamaker DM. Fractures and dislocations of the mandible. In: Newton CD, Nunamaker DM, eds. Textbook of small animal orthopaedics. Philadelphia: JB Lippincott Co, 1985;297306.

    • Search Google Scholar
    • Export Citation
  • 21.

    Roush JK, Wilson JW. Healing of mandibular body osteotomies after plate and intramedullary pin fixation. Vet Surg 1989;18:190196.

  • 22.

    Boudrieau RJ, Tidwell AT, Ullman SL. Correction of mandibular nonunion and malocclusion by plate fixation and autogenous cortical bone grafts in two dogs. J Am Vet Med Assoc 1994;204:744750.

    • Search Google Scholar
    • Export Citation
  • 23.

    Boudrieau RJ, Kudisch M. Miniplate fixation for repair of mandibular and maxillary fractures in 15 dogs and 3 cats. Vet Surg 1996;25:277291.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 24.

    Tepic S, Perren SM. The biomechanics of the PC-Fix internal fixator. Injury 1995;26:S5–S19.

  • 25.

    Verstraete FJM, Ligthelm AJ. Dental trauma caused by screws in internal fixation of mandibular osteotomies in the dog. Vet Comp Orthop Traumatol 1992;5:104108.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 26.

    Roush JK, Howard PE, Wilson JW. Normal blood supply to the canine mandible and mandibular teeth. Am J Vet Res 1989;50:904907.

  • 27.

    Bishop JG, Matthews JL, Dorman JHL. Blood flow and blood pressure in the mandibular artery. J Dent Res 1959;38:244250.

  • 28.

    Hellem S, Ostrup LT. Normal and retrograde blood supply to the body of the mandible in the dog. II. The role played by periosteo-medullary and symphyseal anastomoses. Int J Oral Surg 1981;10:3142.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 29.

    Patel VV, Zhao L, Wong P. Controlling bone morphogenetic protein diffusion and bone morphogenetic protein-stimulated bone growth using fibrin glue. Spine 2006;31:12011206.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 30.

    Suzuki Y, Montagne K, Nishihara A. BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling. J Biochem (Tokyo) 2008;143:199206.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 31.

    Sciadini MF, Johnson KD. Evaluation of recombinant human bone morphogenetic protein-2 as a bone-graft substitute in a canine segmental defect model. J Orthop Res 2000;18:289302.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 32.

    De Biase P, Capanna R. Clinical applications of BMPs. Injury 2005;36:S43–S46.

  • 33.

    Faria ML, Lu Y, Heaney K. Recombinant human bone morphogenetic protein-2 in absorbable collagen sponge enhances bone healing of tibial osteotomies in dogs. Vet Surg 2007;36:122131.

    • Crossref
    • Search Google Scholar
    • Export Citation

Advertisement

Mandibular reconstruction after gunshot trauma in a dog by use of recombinant human bone morphogenetic protein-2

John R. LewisMatthew J. Ryan Veterinary Hospital, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010

Search for other papers by John R. Lewis in
Current site
Google Scholar
PubMed
Close
 VMD, DAVDC
,
Randy J. BoudrieauDepartment of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536

Search for other papers by Randy J. Boudrieau in
Current site
Google Scholar
PubMed
Close
 DVM, DACVS
,
Alexander M. ReiterMatthew J. Ryan Veterinary Hospital, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010

Search for other papers by Alexander M. Reiter in
Current site
Google Scholar
PubMed
Close
 Dr med vet, DAVDC
,
Howard J. SeehermanWyeth Discovery Research, 200 Cambridge Park Dr, Cambridge, MA 02140

Search for other papers by Howard J. Seeherman in
Current site
Google Scholar
PubMed
Close
 VMD, PhD
, and
Robert S. GilleyMatthew J. Ryan Veterinary Hospital, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010

Search for other papers by Robert S. Gilley in
Current site
Google Scholar
PubMed
Close
 DVM, PhD, DAVCS
View More View Less

Abstract

Case Description—A 6-year-old German Shorthaired Pointer was evaluated for possible reconstruction of a mandibular defect resulting from gunshot trauma.

Clinical Findings—A 5-cm defect of the right mandibular body was evident. A segment of the mandibular body was removed 9 weeks earlier because of severe contamination and comminution associated with gunshot trauma. Subsequent right-sided mandibular drift resulted in malocclusion in which the left mandibular canine tooth caused trauma to mucosa of the hard palate medial to the left maxillary canine tooth. The right maxillary canine tooth caused trauma to gingiva lingual to the right mandibular canine tooth.

Treatment and Outcome—The right mandible was stabilized with a 2.0-mm maxillofacial miniplate positioned along the lateral alveolar margin and a 2.4-mm locking mandibular reconstruction plate placed along the ventrolateral mandible. An absorbable compressionresistant matrix containing collagen, hydroxyapatite, and tricalcium phosphate was soaked in recombinant human bone morphogenetic protein-2 (rhBMP-2; 7.2 mL of a 0.5 mg/mL solution for a dose of 3.6 mg) and placed in the defect. By 4 weeks after surgery, an exuberant callus was evident at the site of the defect. By 7 months after surgery, the callus had remodeled, resulting in normal appearance, normal occlusion, and excellent function of the jaw.

Clinical Relevance—Mandibular defects resulting from gunshot trauma can be treated by removal of contaminated tissue and comminuted bone fragments, followed by staged reconstruction. The combination of rhBMP-2 and compression-resistant matrix was effective in a staged mandibular reconstruction in a dog with a severe traumatic mandibular defect.

Abstract

Case Description—A 6-year-old German Shorthaired Pointer was evaluated for possible reconstruction of a mandibular defect resulting from gunshot trauma.

Clinical Findings—A 5-cm defect of the right mandibular body was evident. A segment of the mandibular body was removed 9 weeks earlier because of severe contamination and comminution associated with gunshot trauma. Subsequent right-sided mandibular drift resulted in malocclusion in which the left mandibular canine tooth caused trauma to mucosa of the hard palate medial to the left maxillary canine tooth. The right maxillary canine tooth caused trauma to gingiva lingual to the right mandibular canine tooth.

Treatment and Outcome—The right mandible was stabilized with a 2.0-mm maxillofacial miniplate positioned along the lateral alveolar margin and a 2.4-mm locking mandibular reconstruction plate placed along the ventrolateral mandible. An absorbable compressionresistant matrix containing collagen, hydroxyapatite, and tricalcium phosphate was soaked in recombinant human bone morphogenetic protein-2 (rhBMP-2; 7.2 mL of a 0.5 mg/mL solution for a dose of 3.6 mg) and placed in the defect. By 4 weeks after surgery, an exuberant callus was evident at the site of the defect. By 7 months after surgery, the callus had remodeled, resulting in normal appearance, normal occlusion, and excellent function of the jaw.

Clinical Relevance—Mandibular defects resulting from gunshot trauma can be treated by removal of contaminated tissue and comminuted bone fragments, followed by staged reconstruction. The combination of rhBMP-2 and compression-resistant matrix was effective in a staged mandibular reconstruction in a dog with a severe traumatic mandibular defect.

Contributor Notes

Dr. Seeherman is an employee of Wyeth Pharmaceuticals, which provided the rhBMP-2. Medtronic Sofamor Danek supplied the compression-resistant matrix.

Address correspondence to Dr. Lewis.