Characterization of hypertriglyceridemia and response to treatment with insulin in llamas and alpacas: 31 cases (1995–2005)

Laura H. Waitt Vernon Veterinary Hospital, 14110 Bradshaw Rd, Mount Vernon, WA 98273; and the Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331-4802.

Search for other papers by Laura H. Waitt in
Current site
Google Scholar
PubMed
Close
 DVM, DACVIM
and
Christopher K. Cebra Vernon Veterinary Hospital, 14110 Bradshaw Rd, Mount Vernon, WA 98273; and the Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331-4802.

Search for other papers by Christopher K. Cebra in
Current site
Google Scholar
PubMed
Close
 VMD, MS, DACVIM

Abstract

Objective—To evaluate camelids with hypertriglyceridemia with regard to signalment, clinical features of disease, and response to treatment with insulin.

Design—Retrospective case series.

Animals—23 alpacas and 8 llamas with hypertriglyceridemia.

Procedures—For analysis of medical record data, 20 hypertriglyceridemic camelids with multiple recorded measurements of serum or plasma triglycerides concentration were classified as follows: those with an initial triglycerides concentration > 60 to ≥ 500 mg/dL that were or were not treated with insulin (HT-I and HT-N camelids, respectively) and those with an initial triglycerides concentration > 500 mg/dL that were treated with insulin (lipemic [LIP-I] camelids). Only 1 recorded triglycerides concentration was available for an additional 11 hypertriglyceridemic camelids; data from those records were included in the characterization of signalment and clinical features of disease.

Results—Compared with the general population of hospitalized camelids, hypertriglyceridemic camelids did not differ significantly with respect to age or sex. Of 22 female camelids, only 7 were lactating or pregnant. Serum or plasma triglycerides concentrations in HT-N and HT-I camelids did not differ significantly at admission, but triglycerides concentrations in HT-I camelids decreased significantly after insulin treatment. Posttreatment triglycerides concentrations in HT-I camelids were significantly lower than those in HT-N camelids. During the period of hospitalization, triglycerides concentrations in HT-N camelids increased, whereas those in LIP-I camelids decreased significantly.

Conclusions and Clinical Relevance—Results indicated that hypertriglyceridemia affects llamas and alpacas of all ages and both sexes. Insulin treatment may reduce serum or plasma triglycerides concentrations in camelids with hypertriglyceridemia.

Abstract

Objective—To evaluate camelids with hypertriglyceridemia with regard to signalment, clinical features of disease, and response to treatment with insulin.

Design—Retrospective case series.

Animals—23 alpacas and 8 llamas with hypertriglyceridemia.

Procedures—For analysis of medical record data, 20 hypertriglyceridemic camelids with multiple recorded measurements of serum or plasma triglycerides concentration were classified as follows: those with an initial triglycerides concentration > 60 to ≥ 500 mg/dL that were or were not treated with insulin (HT-I and HT-N camelids, respectively) and those with an initial triglycerides concentration > 500 mg/dL that were treated with insulin (lipemic [LIP-I] camelids). Only 1 recorded triglycerides concentration was available for an additional 11 hypertriglyceridemic camelids; data from those records were included in the characterization of signalment and clinical features of disease.

Results—Compared with the general population of hospitalized camelids, hypertriglyceridemic camelids did not differ significantly with respect to age or sex. Of 22 female camelids, only 7 were lactating or pregnant. Serum or plasma triglycerides concentrations in HT-N and HT-I camelids did not differ significantly at admission, but triglycerides concentrations in HT-I camelids decreased significantly after insulin treatment. Posttreatment triglycerides concentrations in HT-I camelids were significantly lower than those in HT-N camelids. During the period of hospitalization, triglycerides concentrations in HT-N camelids increased, whereas those in LIP-I camelids decreased significantly.

Conclusions and Clinical Relevance—Results indicated that hypertriglyceridemia affects llamas and alpacas of all ages and both sexes. Insulin treatment may reduce serum or plasma triglycerides concentrations in camelids with hypertriglyceridemia.

Contributor Notes

Presented in part at the 24th Annual American College of Veterinary Internal Medicine Forum, Louisville, June 2006.

Address correspondence to Dr. Waitt.
  • 1.

    Tornquist SJ, Van Saun RJ, Smith BB, et al. Hepatic lipidosis in llamas and alpacas: 31 cases (1991–1997). J Am Vet Med Assoc 1999;214:13681372.

    • Search Google Scholar
    • Export Citation
  • 2.

    Van Saun RJ, Callihan BR, Tornquist SJ. Nutritional support for treatment of hepatic lipidosis in a llama. J Am Vet Med Assoc 2000;217:15311535.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Anderson DE, Constable PD, Yvorchuk KE, et al. Hyperlipemia and ketonuria in an alpaca and a llama. J Vet Intern Med 1994;3:207211.

  • 4.

    Saulez MN, Cebra CK, Valentine BA. Necrotizing hepatitis associated with enteric salmonellosis in an alpaca. Can Vet J 2004;45:321323.

  • 5.

    Hughes KJ, Hodgson DR, Dart AJ. Equine hyperlipaemia: a review. Aust Vet J 2004;82:136142.

  • 6.

    Watson TDG, Burns L, Love S, et al. Plasma lipids, lipoproteins and post-heparin lipases in ponies with hyperlipaemia. Equine Vet J 1992;24:341346.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7.

    Herdt TH. Fatty liver in dairy cows. Vet Clin North Am Food Anim Pract 1988;4:269287.

  • 8.

    Gummer RR. Etiology of lipid-related metabolic disorders in cows. J Dairy Sci 1993;76:38823896.

  • 9.

    Cebra CK, Tornquist SJ, Jester RM, et al. Assessment of the metabolic effects of hydrocortisone on llamas before and after feed restriction. Am J Vet Res 2004;65:10021005.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 10.

    Tornquist SJ, Cebra CK, Van Saun RJ, et al. Metabolic changes and induction of hepatic lipidosis during feed restriction in llamas. Am J Vet Res 2001;62:10811087.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11.

    Cebra CK, Tornquist SJ. Assessment of the effects of epinephrine and insulin on plasma and serum biochemical variables in llamas and alpacas. Am J Vet Res 2004;65:16921696.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12.

    Cebra CK, Tornquist SJ, McKane SA. Effects of hydrocortisone on substrates of energy metabolism in alpacas. Am J Vet Res 2002;63:12691274.

  • 13.

    Cebra CK, Tornquist SJ, Van Saun RJ, et al. Glucose tolerance testing in llamas and alpacas. Am J Vet Res 2001;62:682686.

  • 14.

    Cebra CK, McKane SA, Tornquist SJ. Effects of exogenous insulin on glucose tolerance in alpacas. Am J Vet Res 2001;62:15441547.

  • 15.

    Araya AV, Atwater I, Navia MA, et al. Evaluation of insulin resistance in two kinds of South American camelids: llamas and alpacas. Comp Med 2000;50:490494.

    • Search Google Scholar
    • Export Citation
  • 16.

    Cebra CK, Tornquist SJ, Jester RM, et al. Assessment of the effects of feed restriction and amino acid supplementation on glucose tolerance in llamas. Am J Vet Res 2004;65:9961001.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 17.

    Ueda J, Cebra CK, Tornquist SJ. Assessment of the effects of exogenous long-acting insulin on glucose tolerance in alpacas. Am J Vet Res 2004;65:16881691.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 18.

    Nitzan M. Uremic hypertriglyceridemia-impaired removal versus increased production. Nutr Rev 1977;35:9596.

Advertisement